ID A0A087CPQ2_9BIFI Unreviewed; 289 AA.
AC A0A087CPQ2;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Dehydrogenase or reductase protein {ECO:0000313|EMBL:KFI85252.1};
DE EC=1.1.1.188 {ECO:0000313|EMBL:KFI85252.1};
GN ORFNames=BREU_1976 {ECO:0000313|EMBL:KFI85252.1};
OS Bifidobacterium reuteri DSM 23975.
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Bifidobacterium.
OX NCBI_TaxID=1437610 {ECO:0000313|EMBL:KFI85252.1, ECO:0000313|Proteomes:UP000028984};
RN [1] {ECO:0000313|EMBL:KFI85252.1, ECO:0000313|Proteomes:UP000028984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 23975 {ECO:0000313|EMBL:KFI85252.1,
RC ECO:0000313|Proteomes:UP000028984};
RA Ventura M., Milani C., Lugli G.A.;
RT "Genomics of Bifidobacteria.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFI85252.1}.
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DR EMBL; JGZK01000008; KFI85252.1; -; Genomic_DNA.
DR RefSeq; WP_044089546.1; NZ_JGZK01000008.1.
DR AlphaFoldDB; A0A087CPQ2; -.
DR STRING; 1437610.BREU_1976; -.
DR eggNOG; COG0656; Bacteria.
DR OrthoDB; 9804790at2; -.
DR Proteomes; UP000028984; Unassembled WGS sequence.
DR GO; GO:0036131; F:prostaglandin D2 11-ketoreductase activity; IEA:UniProtKB-EC.
DR GO; GO:0047017; F:prostaglandin-F synthase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:KFI85252.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000028984}.
FT DOMAIN 30..273
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 58
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 120
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 87
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 289 AA; 31904 MW; FCAE92861EBAC6E8 CRC64;
MTNGHINPAN VPDIPLKDGH SIPQIGLGVL RIDDDGVTPV VESALEAGYR HIDGAAGYNN
EAGVGRALAA TGYNTGAKRE TLWVTTKLRD SQQGYDSALR AFDDSLAKLQ LDYVDMYMIH
WPTPFDWRST DTWKAFIKLR TEGRARTLGV CNFMPADLDR LYQETGSWPA VNQIELHPTW
QQREVVTYCK EHGIAVEAYS PMARGADLNA GDGTIARIAE AHQVSPAQVI LRWHIENGTI
IIPKSVHAER QQENLDLFGF ALTAEEHEAI DALDGPTRAG HDPATFTYA
//
