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Database: UniProt
Entry: A0A087E0W6_9BIFI
LinkDB: A0A087E0W6_9BIFI
Original site: A0A087E0W6_9BIFI 
ID   A0A087E0W6_9BIFI        Unreviewed;       523 AA.
AC   A0A087E0W6;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   05-JUL-2017, entry version 24.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=BSTEL_1003 {ECO:0000313|EMBL:KFJ01417.1};
OS   Bifidobacterium stellenboschense.
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Bifidobacterium.
OX   NCBI_TaxID=762211 {ECO:0000313|EMBL:KFJ01417.1, ECO:0000313|Proteomes:UP000029004};
RN   [1] {ECO:0000313|EMBL:KFJ01417.1, ECO:0000313|Proteomes:UP000029004}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 23968 {ECO:0000313|EMBL:KFJ01417.1,
RC   ECO:0000313|Proteomes:UP000029004};
RA   Ventura M., Milani C., Lugli G.A.;
RT   "Genomics of Bifidobacteria.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KFJ01417.1}.
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DR   EMBL; JGZP01000001; KFJ01417.1; -; Genomic_DNA.
DR   RefSeq; WP_034525649.1; NZ_JGZP01000001.1.
DR   EnsemblBacteria; KFJ01417; KFJ01417; BSTEL_1003.
DR   Proteomes; UP000029004; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000029004};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029004}.
FT   DOMAIN      208    347       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      423    492       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     216    223       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   523 AA;  57864 MW;  73184A0CC42CF50F CRC64;
     MADEPRDPVA EANHIWSDTL TLLKHNSSLS PRDKGWLEGV YPEGVFGTTI VLCVENAGTR
     QALENELRQP LLEAMNMVTG EDMTPAFKIA PRQPAPAKPK PTPSRRATAP KRASGIDADN
     PPSIADLGKE PYGSRGPVPN VPSSMPATIP TPVDMATAAG YPMSRNKVAR DPETHLNKNA
     TFDTFVPGDS NRFARTVALA VAEGSGRDFN PLCIYGGSGL GKTHLLNAIG NYALVKDPSL
     KVRYVNSEEF TNEFIEALQN TTQNQGQIAE FNRRYREVDV LLIDDIQFLG GKEATLEQFF
     HTFNALHQAN KRIVIASDVA PKNLKGFEAR LISRFDSGLT VDVKPPDLET RIAILRMMAS
     MNHSNIPNDV LDLIAERFTE NIRELEGALT RVTAVASLSN QPVTRTMAEQ TLQDFFTTDV
     EVKPTDIIGQ VAKYFHLTFE DIVGKSRMKN IAIARQVAMY LTREMTSLSL VDIGKVFGGK
     DHTTVMHACD RISNGMQDRQ EIYNYVMELT VRLKQGNTDF KQK
//
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