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Database: UniProt
Entry: A0A087E757_9BIFI
LinkDB: A0A087E757_9BIFI
Original site: A0A087E757_9BIFI 
ID   A0A087E757_9BIFI        Unreviewed;       561 AA.
AC   A0A087E757;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   05-JUL-2017, entry version 24.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=BISU_0078 {ECO:0000313|EMBL:KFJ03608.1};
OS   Bifidobacterium subtile.
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Bifidobacterium.
OX   NCBI_TaxID=77635 {ECO:0000313|EMBL:KFJ03608.1, ECO:0000313|Proteomes:UP000029055};
RN   [1] {ECO:0000313|EMBL:KFJ03608.1, ECO:0000313|Proteomes:UP000029055}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 11597 {ECO:0000313|EMBL:KFJ03608.1,
RC   ECO:0000313|Proteomes:UP000029055};
RA   Ventura M., Milani C., Lugli G.A.;
RT   "Genomics of Bifidobacteria.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KFJ03608.1}.
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DR   EMBL; JGZR01000006; KFJ03608.1; -; Genomic_DNA.
DR   RefSeq; WP_024464439.1; NZ_JGZR01000006.1.
DR   EnsemblBacteria; KFJ03608; KFJ03608; BISU_0078.
DR   Proteomes; UP000029055; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000029055};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029055}.
FT   DOMAIN      250    389       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      465    534       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     258    265       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   561 AA;  61470 MW;  AFADCCC75F255CE6 CRC64;
     MTDEQNDPAS QAAHMWSDAL AVLSHNASLT PRARGWLEGV VPEAVYGTTI VLCVANSSTQ
     QALQSDLNEP LLAALHMVSG QNMLPAFKIV PPIEPPAAPP SETQPSQPAS SATQPAEQPT
     EGSSFDAPGG ARTGFSHNYD PYSGRSSAPV ASQPTLDSSS SAAYAAPMPR EAPDAAQSAY
     APQSHQSHEA EQYSANPHHV DSYRVDQHRA SLDPQTHLNK NATFDTFVPG DSNRFARTVA
     LAVAEGSGRD FNPLCIYGGS GLGKTHLLNA IGNYALVKDE SVKVRYVTSE EFTNEFIEAL
     QTPNQSQGQI ADFNRRYREV DVLLIDDIQF LGGKEATLEQ FFHTFNALYQ ANKRIVIASD
     VAPKNLKGFE ARLISRFESG LTVDIKPPDL ETRIAILRMM ASMSHSNIPN DVLDLIAERF
     TENIRELEGA LTRVTAVASL SNQPVSRALA EQTLQDFFTS NVEIKPTDII SQVAKYFHLT
     FDDLVGRART KNVALARQVA MYLAREMTSM SLVDIGEVFG GRDHTTVMHA YTRVSGEMQE
     KQEIYNYVME LTVRLKQHTN D
//
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