ID A0A087EAU8_9BIFI Unreviewed; 533 AA.
AC A0A087EAU8;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Glycoside hydrolase family 43 protein {ECO:0000313|EMBL:MSS13404.1};
DE SubName: Full=Xylosidase {ECO:0000313|EMBL:KFJ04899.1};
DE EC=3.2.1.37 {ECO:0000313|EMBL:KFJ04899.1};
DE EC=3.2.1.55 {ECO:0000313|EMBL:KFJ04899.1};
GN ORFNames=BITS_1417 {ECO:0000313|EMBL:KFJ04899.1}, FYJ32_08160
GN {ECO:0000313|EMBL:MSS13404.1};
OS Bifidobacterium tsurumiense.
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Bifidobacterium.
OX NCBI_TaxID=356829 {ECO:0000313|EMBL:KFJ04899.1, ECO:0000313|Proteomes:UP000029080};
RN [1] {ECO:0000313|EMBL:KFJ04899.1, ECO:0000313|Proteomes:UP000029080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 13495 {ECO:0000313|EMBL:KFJ04899.1,
RC ECO:0000313|Proteomes:UP000029080};
RA Ventura M., Milani C., Lugli G.A.;
RT "Genomics of Bifidobacteria.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:MSS13404.1, ECO:0000313|Proteomes:UP000482439}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BSM-380-WT-2B {ECO:0000313|EMBL:MSS13404.1,
RC ECO:0000313|Proteomes:UP000482439};
RA Wylensek D., Hitch T.C.A., Clavel T.;
RT "In-depth cultivation of the pig gut microbiome towards novel bacterial
RT diversity and tailored functional studies.";
RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 43 family.
CC {ECO:0000256|ARBA:ARBA00009865, ECO:0000256|RuleBase:RU361187}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFJ04899.1}.
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DR EMBL; JGZU01000017; KFJ04899.1; -; Genomic_DNA.
DR EMBL; VULW01000005; MSS13404.1; -; Genomic_DNA.
DR RefSeq; WP_026642428.1; NZ_VULW01000005.1.
DR AlphaFoldDB; A0A087EAU8; -.
DR STRING; 356829.BITS_1417; -.
DR eggNOG; COG3507; Bacteria.
DR OrthoDB; 9801455at2; -.
DR Proteomes; UP000029080; Unassembled WGS sequence.
DR Proteomes; UP000482439; Unassembled WGS sequence.
DR GO; GO:0046556; F:alpha-L-arabinofuranosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0009044; F:xylan 1,4-beta-xylosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd18617; GH43_XynB-like; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR041542; GH43_C2.
DR InterPro; IPR006710; Glyco_hydro_43.
DR InterPro; IPR023296; Glyco_hydro_beta-prop_sf.
DR PANTHER; PTHR42812; BETA-XYLOSIDASE; 1.
DR PANTHER; PTHR42812:SF12; BETA-XYLOSIDASE-RELATED; 1.
DR Pfam; PF17851; GH43_C2; 1.
DR Pfam; PF04616; Glyco_hydro_43; 1.
DR SUPFAM; SSF75005; Arabinanase/levansucrase/invertase; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361187};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361187};
KW Reference proteome {ECO:0000313|Proteomes:UP000029080}.
FT DOMAIN 365..526
FT /note="Beta-xylosidase C-terminal Concanavalin A-like"
FT /evidence="ECO:0000259|Pfam:PF17851"
FT REGION 412..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..434
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 19
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT ACT_SITE 187
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT SITE 126
FT /note="Important for catalytic activity, responsible for
FT pKa modulation of the active site Glu and correct
FT orientation of both the proton donor and substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-2"
SQ SEQUENCE 533 AA; 57729 MW; 9BAE60060630AECB CRC64;
MTLFNCKPAK RIASGFHPDP SICEKPDGGY VMVNSSFEFM PGLPVFESED GEHWTKVGHA
LSRPSQFPYE SMGNSQGIYA PTIRYHDGLY YLIVTNVNVG NMLLTASDPS GEWSDPIWIP
DWPGIDPSLF FDDDGTVYIC GNESGCVDED GNHEEAGIYL SRLDVTTGEV LDKRKRICGG
ITGSNPEGPH MLKRGDMYYL MWAEGGTESG HMENIARSNK ADGPYEMYSG NPLITNRSTH
LTLQAIGHCD CAHFEDERTL MVFHGTRNND EYPAQGWIGR EPYAVWFTWK DGWPQLADQS
YDCTLNGNGD ALEHDVEWIT PGRDDYGRYS VSPNQGVADS DESVFDIEVS ASGNDFDLPN
DGAPLIGTRQ TDMDCLFEAA VVPGVSCETA VAGIAAYGND KHVITVSIER GAAKDSESAE
NAPNKQGGKD STSAEQYTVS AQVNNAGLRS TVGSIAMDGS QPVTLRLLGT NAGYVCSVQT
ADGLVHELGP VPGKVLSFTN AGGFTGTLLG VFAHGTGQVK FSQVRYQPLM ASR
//
