ID A0A087GID4_ARAAL Unreviewed; 434 AA.
AC A0A087GID4;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=mannose-1-phosphate guanylyltransferase {ECO:0000256|ARBA:ARBA00012387};
DE EC=2.7.7.13 {ECO:0000256|ARBA:ARBA00012387};
GN OrderedLocusNames=AALP_Aa7g159400 {ECO:0000313|EMBL:KFK29636.1};
OS Arabis alpina (Alpine rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Arabideae; Arabis.
OX NCBI_TaxID=50452 {ECO:0000313|EMBL:KFK29636.1, ECO:0000313|Proteomes:UP000029120};
RN [1] {ECO:0000313|Proteomes:UP000029120}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Pajares {ECO:0000313|Proteomes:UP000029120};
RX PubMed=27246759; DOI=10.1038/nplants.2014.23;
RA Willing E.M., Rawat V., Mandakova T., Maumus F., James G.V.,
RA Nordstroem K.J., Becker C., Warthmann N., Chica C., Szarzynska B.,
RA Zytnicki M., Albani M.C., Kiefer C., Bergonzi S., Castaings L.,
RA Mateos J.L., Berns M.C., Bujdoso N., Piofczyk T., de Lorenzo L.,
RA Barrero-Sicilia C., Mateos I., Piednoel M., Hagmann J., Chen-Min-Tao R.,
RA Iglesias-Fernandez R., Schuster S.C., Alonso-Blanco C., Roudier F.,
RA Carbonero P., Paz-Ares J., Davis S.J., Pecinka A., Quesneville H.,
RA Colot V., Lysak M.A., Weigel D., Coupland G., Schneeberger K.;
RT "Genome expansion of Arabis alpina linked with retrotransposition and
RT reduced symmetric DNA methylation.";
RL Nat. Plants 1:14023-14023(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC ChEBI:CHEBI:58409; EC=2.7.7.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001083};
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP
CC route): step 1/1. {ECO:0000256|ARBA:ARBA00004823}.
CC -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC {ECO:0000256|ARBA:ARBA00007274}.
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DR EMBL; CM002875; KFK29636.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087GID4; -.
DR EnsemblPlants; KFK29636; KFK29636; AALP_AA7G159400.
DR Gramene; KFK29636; KFK29636; AALP_AA7G159400.
DR eggNOG; KOG1322; Eukaryota.
DR OMA; EDSHVGP; -.
DR OrthoDB; 646404at2759; -.
DR UniPathway; UPA00126; UER00930.
DR Proteomes; UP000029120; Chromosome 7.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IEA:InterPro.
DR GO; GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd06425; M1P_guanylylT_B_like_N; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR045233; GMPPB_N.
DR InterPro; IPR001451; Hexapep.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR22572:SF141; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE 3-RELATED; 1.
DR PANTHER; PTHR22572; SUGAR-1-PHOSPHATE GUANYL TRANSFERASE; 1.
DR Pfam; PF00132; Hexapep; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000029120};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 77..310
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
SQ SEQUENCE 434 AA; 48135 MW; 5E2581EE62819D05 CRC64;
MVLRLDLRFN SILGIEVNPY SEDLSHSTHL ANPNPTRRPL LRRSLLIAGC SRLLCDKKMV
AFGKYLQLPQ QKSHKMKALI LVGGFGTRLR PLTFTMPKPL VDFANKPMIL HQIEALKAAG
VTQVVLAINH QQPQVMLNFV KEYEKKLEIK ITFSQETEPL GTAGPLALAR DKLIDESGEP
FFVLNSDVIC EYPLLEMIEF HKASGAEASI MVTKVDDPSK YGVVVMEEDT SRVESFVEKP
KHFVGNKINA GIYLLNPSVL DRIELRRTSI EKEIFPKIAS EKKLYAMVLP GFWMDIGQPK
DYITGQRMYL DSLRKKAPQE LVTGDHTVGN VLADETAVIG EHCLIGPDVV IGPGCVIDSG
VRLFGCTIMR GARIKTNACV SNSIVGWDST VGRWARVVNI SVLGKDVHVA DAEVYSNGAT
IIEDQMSVKP EIVI
//
