ID A0A087GNW2_ARAAL Unreviewed; 1312 AA.
AC A0A087GNW2;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=tripeptidyl-peptidase II {ECO:0000256|ARBA:ARBA00012462};
DE EC=3.4.14.10 {ECO:0000256|ARBA:ARBA00012462};
GN OrderedLocusNames=AALP_Aa6g128200 {ECO:0000313|EMBL:KFK31564.1};
OS Arabis alpina (Alpine rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Arabideae; Arabis.
OX NCBI_TaxID=50452 {ECO:0000313|EMBL:KFK31564.1, ECO:0000313|Proteomes:UP000029120};
RN [1] {ECO:0000313|Proteomes:UP000029120}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Pajares {ECO:0000313|Proteomes:UP000029120};
RX PubMed=27246759; DOI=10.1038/nplants.2014.23;
RA Willing E.M., Rawat V., Mandakova T., Maumus F., James G.V.,
RA Nordstroem K.J., Becker C., Warthmann N., Chica C., Szarzynska B.,
RA Zytnicki M., Albani M.C., Kiefer C., Bergonzi S., Castaings L.,
RA Mateos J.L., Berns M.C., Bujdoso N., Piofczyk T., de Lorenzo L.,
RA Barrero-Sicilia C., Mateos I., Piednoel M., Hagmann J., Chen-Min-Tao R.,
RA Iglesias-Fernandez R., Schuster S.C., Alonso-Blanco C., Roudier F.,
RA Carbonero P., Paz-Ares J., Davis S.J., Pecinka A., Quesneville H.,
RA Colot V., Lysak M.A., Weigel D., Coupland G., Schneeberger K.;
RT "Genome expansion of Arabis alpina linked with retrotransposition and
RT reduced symmetric DNA methylation.";
RL Nat. Plants 1:14023-14023(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Release of an N-terminal tripeptide from a polypeptide.;
CC EC=3.4.14.10; Evidence={ECO:0000256|ARBA:ARBA00001910};
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
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DR EMBL; CM002874; KFK31564.1; -; Genomic_DNA.
DR EnsemblPlants; KFK31564; KFK31564; AALP_AA6G128200.
DR Gramene; KFK31564; KFK31564; AALP_AA6G128200.
DR eggNOG; KOG1114; Eukaryota.
DR OMA; SLRDFQC; -.
DR OrthoDB; 2441948at2759; -.
DR Proteomes; UP000029120; Chromosome 6.
DR GO; GO:0005737; C:cytoplasm; IEA:EnsemblPlants.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0003729; F:mRNA binding; IEA:EnsemblPlants.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008240; F:tripeptidyl-peptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04857; Peptidases_S8_Tripeptidyl_Aminopeptidase_II; 1.
DR Gene3D; 1.25.40.710; -; 1.
DR Gene3D; 2.60.40.3170; -; 1.
DR Gene3D; 6.10.250.3080; -; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 2.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR034051; TPP_II_domain.
DR InterPro; IPR046939; TPPII_C_sf.
DR InterPro; IPR048384; TPPII_GBD.
DR InterPro; IPR048383; TPPII_Ig-like-1.
DR InterPro; IPR022229; TPPII_Ig-like-2.
DR InterPro; IPR046940; TPPII_Ig-like_sf.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR PANTHER; PTHR43806:SF14; TRIPEPTIDYL-PEPTIDASE 2; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF12580; TPPII; 1.
DR Pfam; PF21316; TPPII_GBD; 1.
DR Pfam; PF21223; TPPII_Ig-like-1; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000256|ARBA:ARBA00022438};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000029120};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}.
FT DOMAIN 68..531
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT DOMAIN 577..685
FT /note="Tripeptidyl-peptidase II first Ig-like"
FT /evidence="ECO:0000259|Pfam:PF21223"
FT DOMAIN 706..788
FT /note="Tripeptidyl-peptidase II galactose-binding"
FT /evidence="ECO:0000259|Pfam:PF21316"
FT DOMAIN 830..1013
FT /note="Tripeptidyl peptidase II second Ig-like"
FT /evidence="ECO:0000259|Pfam:PF12580"
FT ACT_SITE 77
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 304
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 490
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 1312 AA; 144359 MW; B66E2F8436940D1B CRC64;
MPSSSSETLT ASRVGCGGGG GGGVGGVGAD NASVANFKLN ESTFLASLMP KKEIRADCFV
EAYPEYDGRG VVIAIFDSGF DPSAAGLHVT TDGKPKVLDV IDCTGSGDID TSTVVKADED
GLIRGASGAP LVVNSSWKNP TGEWRVGCKL VYQLFTDDLT SRVKKERKKN WDEKNQEEIA
KAVKNLYDFD QKHSKVEGAK LKKTQEDLQS RVDFLKKQAE KYEDKGPVID AVVWHDGEVW
RVALDTQSLE EDPDSGKLAD FSPLTNYRIE RKYGVFSRLD ACAFVANMYD EGKVLSIVTD
SSPHGTHVAG IATAHHPEEH LLNGVAPGAQ IISCKIGDTR LGSMETGTGL SRALIACLEH
KCDLVNMSYG EPALLPDYGR FVDLVTEAVN KRRLIFVSSA GNSGPALTTV GAPGGTTSSM
IGVGAYVSPA MAAGAHSVVQ PPGEGLEYTW SSRGPTPDGD LGVCISAPGG AVAPVPTWTL
QRRMLMNGTS MASPSACGAI ALLLSAMKAE GIPVSPYSVR RALENTSAPV GDLPEDKLST
GQGLMQVDKA YEYLKKFKDC PCVFYQIKVN LSGKTTPTSR GIYLREATAC RQSTEWTVQV
EPKFHEGASN LKELVPFEEC LELHSTDEGV VRVPDYLLLT HNGRSFNVVV DPTNLGDGVH
YFEVYGIDCK APERGPLFRI PVTITIPKTV ANRPPVISFQ QMSFISGHIE RRFIEVPLGA
TWAEATIRTS GFDTSRRFYI DTLQLCPLRR PIKWESATTF ASPSAKSFAF PVVSGQTMEL
ALAQFWSSGL GSREPTIVDF EIEFHGIGVD KEELILDGSE APIKVEAEAL LASEKLVPVA
VLNKIRVPYQ PVDAQLKTLA TGRDRLLSGK QILALTLTYK FKLEEAAEVK PYIPLLNNRI
YDTKFESQFY MISDANKRVY AMGDVYPESS KLPKGDYKLQ LYLRHENVQL LEKLKQLIVF
IERNMGEIRL NLHSEPDGPI TGNGAFKSSI LMPGVKEAFY VGPPTKDKIP KNTPQGSVLV
GEISYGKLSF DEKEGKSPKD NPVSYPISYV VPPNKPEEDK KAVSAPNSCK SVSERLEEEV
RDTKIKFLGS LKQETEEERS EWKKLCACLK SEYPDYTPLL SKILEGLLSR SDAGDKINHY
EEIIDAANEV VSSVDVDELG RFLLQKSEPE DEEAENLKKK MEMTRDQLAD ALYQKGLALA
RFENLKGEKE GEGGEESGQK DKFEENYKEL TKWVDVKSSK FGTLTVLREK RLSRLGTALK
VLDDLIQNEN EIANKKLYEL KLSLLEELGW NHLVTYEKQW MQVRFPTSLP LF
//
