ID A0A087H288_ARAAL Unreviewed; 1264 AA.
AC A0A087H288;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN OrderedLocusNames=AALP_Aa4g096500 {ECO:0000313|EMBL:KFK36240.1};
OS Arabis alpina (Alpine rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Arabideae; Arabis.
OX NCBI_TaxID=50452 {ECO:0000313|EMBL:KFK36240.1, ECO:0000313|Proteomes:UP000029120};
RN [1] {ECO:0000313|Proteomes:UP000029120}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Pajares {ECO:0000313|Proteomes:UP000029120};
RX PubMed=27246759; DOI=10.1038/nplants.2014.23;
RA Willing E.M., Rawat V., Mandakova T., Maumus F., James G.V.,
RA Nordstroem K.J., Becker C., Warthmann N., Chica C., Szarzynska B.,
RA Zytnicki M., Albani M.C., Kiefer C., Bergonzi S., Castaings L.,
RA Mateos J.L., Berns M.C., Bujdoso N., Piofczyk T., de Lorenzo L.,
RA Barrero-Sicilia C., Mateos I., Piednoel M., Hagmann J., Chen-Min-Tao R.,
RA Iglesias-Fernandez R., Schuster S.C., Alonso-Blanco C., Roudier F.,
RA Carbonero P., Paz-Ares J., Davis S.J., Pecinka A., Quesneville H.,
RA Colot V., Lysak M.A., Weigel D., Coupland G., Schneeberger K.;
RT "Genome expansion of Arabis alpina linked with retrotransposition and
RT reduced symmetric DNA methylation.";
RL Nat. Plants 1:14023-14023(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
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DR EMBL; CM002872; KFK36240.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087H288; -.
DR EnsemblPlants; KFK36240; KFK36240; AALP_AA4G096500.
DR Gramene; KFK36240; KFK36240; AALP_AA4G096500.
DR eggNOG; KOG0926; Eukaryota.
DR OrthoDB; 5490433at2759; -.
DR Proteomes; UP000029120; Chromosome 4.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17982; DEXHc_DHX37; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF99; ATP-DEPENDENT RNA HELICASE DHX37-RELATED; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000029120}.
FT DOMAIN 267..460
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 619..792
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 560..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 638..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 892..926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 62..96
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 892..925
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1264 AA; 141926 MW; A5CCF0870D1C301B CRC64;
MLHLTIRIVT ASSPANRTIF PASETLTPAS VLNILTMVKD DSNLDIMPPR KKKQVSDNKV
NLKKKTIVSK SQKRKLKKLE EDKEKEILLA KTAEILDKYK ISEDVSSLLQ SSKVIGKSAT
KMEKRRRTMQ LSKAGVVTDD ESVKEKEEDD DSCMAEPTTP EHVEIVIPSF PTDSEQVIHD
NELGSDVMIP AEEVCEEDET VDMVLLKARR DDEDEEGFER MDVAVGNEDV TVQGPCVPAF
VVHVSRPAEV EETRKDLPIV MMEQEIMEAI NYHPTVIISG QTGCGKTTQV PQFLYEAGFG
SKQFSSRSGI IGITQPRRVA VLATAKRVAF ELGVRLGKEV GFQVRYDKKM GENSSIKFMT
DGILLREIQT DFLLRRYSVI ILDEAHERSL NTDILIGMLT RVIKIRQEYY EEQQKSLQSG
GTITSENQII TPLKLILMSA TLRVEDFVSG KRLFPKRPPL IEVPTRQYPV TIHFSKKTEI
ADYIGEAYKK VMSIHRKLPQ GGVLVFVTGQ REVDYLCEKL HKSSKQLVAQ AAKRDASVRK
KCDDGSFGGV DMKEIAEAFD DGSNNQNDRF GSYEEDPSEI GDGNYKDDFE EEDMYESDEE
NDWETIDDGF ASSFVDEGKL DALRAAFKAL ADKKGSESAE PTKSIAVENQ EAEQEKKTSP
GKLRVLPLYA MLSPAAQLRV FEEVDEGERL VVVATNVAET SLTIPGIKYV VDTGRVKVKN
YDSKTGMETY EVDWISQASA SQRAGRAGRT GPGHCYRLYS SAVFSNIFEE SSLPEIMKVP
VDGVVLLLKS MNIPKVENFP FPTPPEPSAI REAERCLKAL EALDSNGKLT PLGKAMSRYP
MSPRHSRMLL TVIQMLKQAH NYSRANLVLG YAVAAVAALS LPNPLIMQFE GEKKNESEDA
GKTVKQEDKQ RKKDRKDKIK AARDRFSNPS SDALTVAYAL HSFEVSENGA GFCESNGMHM
KTMDEMSKLK DQLLRIVFSC CTPSETENGF SWTHGTIQDV EKAWKIAASS SSKSPLLQNE
EELLGEAICA GWADRVARKT KTTEYQACAV QEPVFLHRWS SLINSAPELL VYSELLLTNR
PYMHGATRVK PEWLVKHAKS LCVFSTPLKD PKPYYSSEED KVFCLVVPSF GPHLWELPAH
SVAIKEDRDR AAVFGCALLQ GEVLPCLKSV RPLMAGKPET LLEREAWGLE RVGNLVRALN
ELKIDSLESL RKRWEQNPNV LYSEIQAWFQ KKYRDSVKKL WQRMLQEAQV MPLERSVKLK
RSRS
//
