ID A0A087HS70_ARAAL Unreviewed; 800 AA.
AC A0A087HS70;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=CSC1-like protein {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=AALP_Aa1g327200 {ECO:0000313|EMBL:KFK44972.1};
OS Arabis alpina (Alpine rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Arabideae; Arabis.
OX NCBI_TaxID=50452 {ECO:0000313|EMBL:KFK44972.1, ECO:0000313|Proteomes:UP000029120};
RN [1] {ECO:0000313|Proteomes:UP000029120}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Pajares {ECO:0000313|Proteomes:UP000029120};
RX PubMed=27246759; DOI=10.1038/nplants.2014.23;
RA Willing E.M., Rawat V., Mandakova T., Maumus F., James G.V.,
RA Nordstroem K.J., Becker C., Warthmann N., Chica C., Szarzynska B.,
RA Zytnicki M., Albani M.C., Kiefer C., Bergonzi S., Castaings L.,
RA Mateos J.L., Berns M.C., Bujdoso N., Piofczyk T., de Lorenzo L.,
RA Barrero-Sicilia C., Mateos I., Piednoel M., Hagmann J., Chen-Min-Tao R.,
RA Iglesias-Fernandez R., Schuster S.C., Alonso-Blanco C., Roudier F.,
RA Carbonero P., Paz-Ares J., Davis S.J., Pecinka A., Quesneville H.,
RA Colot V., Lysak M.A., Weigel D., Coupland G., Schneeberger K.;
RT "Genome expansion of Arabis alpina linked with retrotransposition and
RT reduced symmetric DNA methylation.";
RL Nat. Plants 1:14023-14023(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; CM002869; KFK44972.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087HS70; -.
DR EnsemblPlants; KFK44972; KFK44972; AALP_AA1G327200.
DR Gramene; KFK44972; KFK44972; AALP_AA1G327200.
DR eggNOG; KOG1134; Eukaryota.
DR OMA; QGIGMFP; -.
DR OrthoDB; 1753647at2759; -.
DR Proteomes; UP000029120; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR PANTHER; PTHR13018:SF98; TO DEHYDRATION PROTEIN, PUTATIVE, EXPRESSED-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000029120};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 420..447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..487
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 575..605
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 7..179
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 201..363
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 374..646
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 737..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..778
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 800 AA; 92260 MW; 3192445E8851FF9B CRC64;
MATLQDIGVS ALINLFGAFL FLIAFALLRI QPINDRVYFP KWYLSGDRNS PRHRSDGTFV
GKFVNLNFKT YFTFLNWMPQ AMKMSESEII RHAGLDSAVF LRIYILGLKI FAPAMVLALV
VLVPVNVSSG TLFFLKKELV VSDIDKLSIS NVQPKSSKFF FHIGVEYLFT LWTCFMLYLE
YDNVASMRLQ YLASQRRRAE QFTVVVRNVP SMPGHTIPDT VDQFFKTNHP EHYLCHQAVY
NANKYAKLVK QREKLQRWFD YYVLKHQRNP HKKPTCRTGF LGLWGKMVDS IEYYEQQIKE
FNHSMSLERQ NVLQDSKLML PVAFVSFDSR WGAAVCAQTQ QSKNPTLWLT SSAPEPRDIY
WQNLAIPFIS LTIRKLLIGI SVFALVFFYM IPIAFVQSLA NLDGLERVAP FLRPVMRLDF
IKSFLQGFLP GLALKIFLWI LPTVLLIMSK IEGYIALSTL ERRAAAKYYY FMLVNVFLGS
IIAGTAFEQL DSFLHQSPSQ IPRTIGVSIP MKATFFITYI MVDGWAGIAG EILRLKPLVI
FHLKNMFIVK TEGDRVRAMD PGFVDFKETL PSLQLYFLLG IVYAVVTPIL LPFILIFFAF
AYLVYRHQII NVYNQQYESC GAFWPHVHGR IVASLLISQL LLMGLLASKE AADSTPLLII
LPILTLSFHK YCKHRFEPAF GKYPLEEAMA KDKLEKETEP ELNMKADLAD AYLHPIFHSF
EEEEEDDEQQ IEEVAEVRAD KHETRSSSPV TELGTPSHHH QVYNSSSPSS HYASAYEQST
SQYEYHYEAH RYEEHEYRYN
//
