ID   A0A087NAG9_9SPHN        Unreviewed;       480 AA.
AC   A0A087NAG9;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Putative tryptophan halogenase {ECO:0000313|EMBL:KFL46122.1};
GN   ORFNames=IL54_1538 {ECO:0000313|EMBL:KFL46122.1};
OS   Sphingobium sp. ba1.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingobium.
OX   NCBI_TaxID=1522072 {ECO:0000313|EMBL:KFL46122.1, ECO:0000313|Proteomes:UP000029094};
RN   [1] {ECO:0000313|EMBL:KFL46122.1, ECO:0000313|Proteomes:UP000029094}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ba1 {ECO:0000313|Proteomes:UP000029094};
RA   Manzari C., Chiara M., Costanza A., Leoni C., Picardi E., Trotta M.,
RA   Volpicella M., D'Erchia A.M., Horner D.S., Pesole G., Ceci L.R.;
RT   "Draft genome sequence of a Kanamycin and Nickel resistant bacterium
RT   Sphingobium species.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFL46122.1}.
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DR   EMBL; JPPQ01000069; KFL46122.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A087NAG9; -.
DR   PATRIC; fig|1522072.3.peg.3366; -.
DR   eggNOG; COG0654; Bacteria.
DR   Proteomes; UP000029094; Unassembled WGS sequence.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006905; Flavin_halogenase.
DR   InterPro; IPR033856; Trp_halogen.
DR   PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR   PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR   Pfam; PF04820; Trp_halogenase; 1.
DR   PIRSF; PIRSF011396; Trp_halogenase; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   4: Predicted;
KW   FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW   Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2}.
FT   ACT_SITE        60
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT   BINDING         60
FT                   /ligand="7-chloro-L-tryptophan"
FT                   /ligand_id="ChEBI:CHEBI:58713"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT   BINDING         309
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT   BINDING         318
FT                   /ligand="L-tryptophan"
FT                   /ligand_id="ChEBI:CHEBI:57912"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT   BINDING         322
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ   SEQUENCE   480 AA;  53617 MW;  71DE64CE05F827AC CRC64;
     MTAAALARTL GPVAQVTLVE SEQIGTIGVG ESTIPPLVAY NRILGINEAD FMRATQATFK
     LGINFENWRV PGESYFHSFG GTGKDHWSAG FQHFWMHGQA QGHDAPYGDY CLELKAAEAG
     RFAHLPDDRM NYAYQLDSGL YARFLRRMAE ADGAQRIEGR IAKVELDSES GDIAALLLDG
     DRRIEGDLFI DCTGFRALLI EGALHVGYDD WTHWLPCDGA VAIQTSSVRP PVPYTCAIAH
     EAGWQWRIPL QHRQGNGIVY CSSFLNPDAA LEKLLASVEG DKLVQPNPIR FRTGARRRQW
     HRNCVAVGLS GGFMEPLEST SIHLIQRAVL RILRMLPAGT VSPLDIAEFN DQQMTDMEQI
     RDFLILHYKA TDRRDTPFWR HCAAMAVPDS LAHRMELFRQ TGRAFRKNEE LFAENSWVQV
     MMGQGITPQS HHPIASKLRP DELTHLLASL KDQVSRTVAN LPEHAAYIAR YCSAQEPVAA
//