ID A0A087QPZ3_APTFO Unreviewed; 470 AA.
AC A0A087QPZ3;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 03-MAY-2023, entry version 35.
DE SubName: Full=Friend leukemia integration 1 transcription factor {ECO:0000313|EMBL:KFM03297.1};
DE Flags: Fragment;
GN ORFNames=AS27_01295 {ECO:0000313|EMBL:KFM03297.1};
OS Aptenodytes forsteri (Emperor penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC Aptenodytes.
OX NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM03297.1, ECO:0000313|Proteomes:UP000053286};
RN [1] {ECO:0000313|EMBL:KFM03297.1, ECO:0000313|Proteomes:UP000053286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM03297.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL225800; KFM03297.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087QPZ3; -.
DR STRING; 9233.A0A087QPZ3; -.
DR Proteomes; UP000053286; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd08541; SAM_PNT-FLI-1; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR003118; Pointed_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR035573; SAM_PNT-FLI-1.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF161; FRIEND LEUKEMIA INTEGRATION 1 TRANSCRIPTION FACTOR; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF02198; SAM_PNT; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SMART; SM00251; SAM_PNT; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR PROSITE; PS51433; PNT; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000053286};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 107..193
FT /note="PNT"
FT /evidence="ECO:0000259|PROSITE:PS51433"
FT DOMAIN 299..379
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 26..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFM03297.1"
FT NON_TER 470
FT /evidence="ECO:0000313|EMBL:KFM03297.1"
SQ SEQUENCE 470 AA; 53106 MW; 741885AE3CDB4DE3 CRC64;
QEALSVVSDD QSLFDSTYGA ATHLPKADMT ASGNPDYGQP HKINPLPPQQ EWINQPVRVN
VKREYDHMNG SRESPVDCSV NKCSKLVGAG TESNPMSYST YMDEKNGPPP NMTTNERRVI
VPADPTLWTQ EHVRQWLEWA IKEYGLMEID TTIFQNMDGK ELCKMNKDDF LRTTSLYNTE
VLLSHLSYLR ETFSTCLHGS PLAEHIQTAI TPFLFVIGSS LLVYNTPSHT EASSRLATKE
DPSYDAVRRT GWGSNMNSGL TKRTQNVNKT TEQQRPQPDP YQILGPTSSR LANPGSGQIQ
LWQFLLELLS DSSNASCITW EGTNGEFKMT DPDEVARRWG ERKSKPNMNY DKLSRALRYY
YDKNIMTKVH GKRYAYKFDF HGIAQALQPH PTESSMYKYP SDLSYMPSYH AHQQKVNFVP
PHPSSMPVTS SSFFGAASPY WTSPAGSIYP NPNVPRHPNA HVSPHLGSYY
//
