ID A0A087QQA5_APTFO Unreviewed; 1982 AA.
AC A0A087QQA5;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
DE Flags: Fragment;
GN ORFNames=AS27_09674 {ECO:0000313|EMBL:KFM03409.1};
OS Aptenodytes forsteri (Emperor penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC Aptenodytes.
OX NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM03409.1, ECO:0000313|Proteomes:UP000053286};
RN [1] {ECO:0000313|EMBL:KFM03409.1, ECO:0000313|Proteomes:UP000053286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM03409.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 3 subfamily. {ECO:0000256|ARBA:ARBA00025789}.
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DR EMBL; KL225807; KFM03409.1; -; Genomic_DNA.
DR STRING; 9233.A0A087QQA5; -.
DR Proteomes; UP000053286; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 10.
DR CDD; cd14617; R-PTPc-B; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 15.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR041201; PTPRJ_TM.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF3; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR Pfam; PF00041; fn3; 15.
DR Pfam; PF18861; PTP_tm; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 17.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 15.
DR PROSITE; PS50853; FN3; 9.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|EMBL:KFM03409.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053286};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}.
FT DOMAIN 97..186
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 187..275
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 361..453
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 454..546
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 627..714
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 715..805
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 894..986
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1248..1341
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1342..1433
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1688..1948
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1866..1939
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFM03409.1"
FT NON_TER 1982
FT /evidence="ECO:0000313|EMBL:KFM03409.1"
SQ SEQUENCE 1982 AA; 221682 MW; 3B420B5DDB52E2B3 CRC64;
QAAPGEAAGC SANLTERRVA GQSVRLRWGA AGRACNFSLT GRSEDGEAAG CQPAPTGNGS
YGCILRGLEA GTWYHLRIEP LSDGEAVNIS VQTDPLPPPR FEINKEKTTL TSLQVQWDPS
SGKVDLYNLV LFDHDNKKIQ EVSVPGRISK TENTFSSLIP GNKYNIVLSA VAGNKSTLEL
HISGSTVPSP VKNIQVSVKT DTIHASWSPG SGHVDSYRLV LLDDHVPVHE IHQEDPLTSY
TFSGLTAGHL YNLSVITQAA GLESSSFQTV RTAPAEVLDL TVTNDDSLDA LEVKWRRPSG
NLDFYNITLS HLGSVKEVKT LQPLVTEIHF DKLTPGRLYQ VTARTISGEL FTDRMATGRT
FPQKVSELKA GGGGWLRSLR VNWLPPAGDW ERYHLLLWNR SALVLNTTLE KDTTEYLIHD
VGLIPGRQYD VEVVVESGDL QSKTSCTGRT APEPVLQLRV KHANESSLGV MWVTPVAEWD
SYVVSLGDRD LTVIKKGLAK EAKEFTFTDL VPGRKYTATI TTISGILSNW TSVEGRTVPA
QVTGLTVASQ GSTNSLFTNW TRALGDVDSY QVLLIHENVV IKNETVPSET NRYHFYPLKP
GGLYSVVVTT VSGGISSRQT IAEGRTVPSS VTGVTVNNSG RSDYLSVSWL PASGDVDSYL
VTLSHDDQIV QTLTISKSFS ECSFSSLTPG TLYNVMITTK SGKYENYSFS QERTVPSSVQ
GLTVSNSARS DYLKVSWLHA SGYFDNYEVI IKNNNDFIQT KSVPKDENEC VFTNLVPGRQ
YSVTVSTRSG KYETSERVYG RTMPESVKEL TLSNRSTEDL QVTWSKAEGD VDKYEIQLLF
NDMKIFPPIF LGNTIEEYWF TALTPGRLYK ILVLTISGDA QRATFIEGLT IPSAVRNIHV
SPNGMTNSLK VSWTPGGGDV DSYTVTIFQQ NHQLDSRSVS KHVSEHIFHK LEAGEQYRVV
VQSNSGTLHS SLAAFGRTIP ASVQELLAHH AYSSHSLLVT WQKAPGVAER YDILLLNEQG
ILLSNKSEPA TAKQHKFEDL LAGKKYKIQV LTVSGGLFSK RAETVGRTVP AAVTNLKVTE
NTTDRLSFSW TTSLGELDSY DIFLYNPDKS LHDRISGEQH LQQCSFQNLR QGRMYRMVIV
THSGDLTNES SVFGRTVPAP VVGLKASNRN MTDSLWFTWG PAAGDVDFYE LNLYNPNGTQ
KETWHRKDLK EWHFQGLIPG RKYTLVVVTH SGDLTNTANA EGRTAPSPPN TVSFTDVANT
SLSITWLGPP DWTDYDDFEL QWLPKDPLTV FNPYSSSKSK VRIMYGLRPG RLYEFSVRTV
SGDSWKTYSQ SQSASVRTKP DKIQSLHCRP QTSTAIACSW TPPNSDFDGY SVECKKLDAP
KLEFSKRIEK DKSLLNIMTL VPHKRYLVSI KVHSADMTSE VVEDSTITMI DRPPQPPPDI
RVNKKEVLIT KSSINFTFNC SWFSDTNGAV KYFTVVVREA DGSEGPKPDE QHPLPSYLEY
KHNDSIRIYQ TNYFASRCAE NPDSDYKSFD IKLGGEMENL GGRCDPDQQK FCDGPLKPRT
AYRISIRAFT QLFSEDPKEL PKPLFADTFF SLPIITEAEP LFGVIEGVSA GLFLIVMLVA
VTALFVCRQK VSNGHERPTA RLSIRRDRPL SVHLNLGQKG NRKTSSPIKV SHFEAHFTKL
QADSNYLLSK EYEDLKDVGR NQTCDIALLP ENRGKNRYNN ILPYDTSRVK LSNVDDDPCS
DYINASYIPG NNFRREYIAT QGPLPGTKDE FWKMAWEQNV HNIVMVTQCV EKGRVKCDHY
WPLDQDSLYY GDLIVEMLSE SVLPEWTIRE FKICSEEQLD STRLIRHFHY TVWPDHGVPE
TTQSLIQFVR TVRDYINRTP DTGPTIVHCS AGVGRTGTFI ALDRILQQLD SKDTVDIYAA
VHDLRLHRVY MVQTECQYVY LHQCVRDVLR ARKLRSEQEN PLFPIYENVN PEYHRDAVYS
RH
//
