ID A0A087QRH2_APTFO Unreviewed; 425 AA.
AC A0A087QRH2;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 08-NOV-2023, entry version 37.
DE SubName: Full=Bone morphogenetic protein 10 {ECO:0000313|EMBL:KFM03826.1};
GN ORFNames=AS27_01333 {ECO:0000313|EMBL:KFM03826.1};
OS Aptenodytes forsteri (Emperor penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC Aptenodytes.
OX NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM03826.1, ECO:0000313|Proteomes:UP000053286};
RN [1] {ECO:0000313|EMBL:KFM03826.1, ECO:0000313|Proteomes:UP000053286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM03826.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; KL225833; KFM03826.1; -; Genomic_DNA.
DR RefSeq; XP_009272066.1; XM_009273791.2.
DR AlphaFoldDB; A0A087QRH2; -.
DR STRING; 9233.A0A087QRH2; -.
DR GeneID; 103894414; -.
DR KEGG; afor:103894414; -.
DR CTD; 27302; -.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000053286; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19401; TGF_beta_BMP10; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF39; BONE MORPHOGENETIC PROTEIN 10; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000053286};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..425
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001828261"
FT DOMAIN 314..425
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 425 AA; 48478 MW; 74812298DCFBE64B CRC64;
MDSVVLQLWA VLCLLVHLAA CSPILSLEHS SLEEDVPLFD EILSEQDGVD FNTLLQNMKN
EFLKTLNLSD IPLHETAKVD PPEYMLELYN RFATDRTSMP SANIIRSFKN EDLASHPIGV
TGIRKYPLLF NVSIPHHEEI TMAELRLYTL VERDQMLYDG LDRKVTIFEV LENDHMGVGE
ERKTVALASR QIYGTSSEWE SFEVTEAIRR WRRAGLTTHR LEVHIESREG EEQNGEGKLD
IDINSEAKHV PLLIVFSDDQ SNDKKEEKQE LNEMIDHEQL LDLEKLEVGN FHGQPGEEAL
LQMRSNIIYD STARIRRNAK GNYCKKTPLY IDFKEIGWDS WIIAPAGYEA YECHGVCAYP
LTEHVTPTKH AIVQTLVHLK NPQKASKACC VPTKLDPISI LYLDAGVVTY KFKYEGMVVS
ECGCR
//
