ID   A0A087R4J1_APTFO        Unreviewed;       689 AA.
AC   A0A087R4J1;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   03-MAY-2023, entry version 28.
DE   SubName: Full=Ski-like {ECO:0000313|EMBL:KFM08395.1};
DE   Flags: Fragment;
GN   ORFNames=AS27_03927 {ECO:0000313|EMBL:KFM08395.1};
OS   Aptenodytes forsteri (Emperor penguin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC   Aptenodytes.
OX   NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM08395.1, ECO:0000313|Proteomes:UP000053286};
RN   [1] {ECO:0000313|EMBL:KFM08395.1, ECO:0000313|Proteomes:UP000053286}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM08395.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the SKI family. {ECO:0000256|ARBA:ARBA00009513}.
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DR   EMBL; KL226095; KFM08395.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A087R4J1; -.
DR   STRING; 9233.A0A087R4J1; -.
DR   Proteomes; UP000053286; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; ISS:AgBase.
DR   GO; GO:0005667; C:transcription regulator complex; ISS:AgBase.
DR   GO; GO:0140297; F:DNA-binding transcription factor binding; ISS:AgBase.
DR   GO; GO:0019904; F:protein domain specific binding; ISS:AgBase.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:AgBase.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:AgBase.
DR   GO; GO:0046332; F:SMAD binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; ISS:AgBase.
DR   CDD; cd21084; DHD_Sno; 1.
DR   Gene3D; 3.10.390.10; SAND domain-like; 1.
DR   Gene3D; 3.10.260.20; Ski; 1.
DR   InterPro; IPR014890; c-SKI_SMAD4-bd_dom.
DR   InterPro; IPR009061; DNA-bd_dom_put_sf.
DR   InterPro; IPR010919; SAND-like_dom_sf.
DR   InterPro; IPR003380; SKI/SNO/DAC.
DR   InterPro; IPR037000; Ski_DNA-bd_sf.
DR   InterPro; IPR023216; Tscrpt_reg_SKI_SnoN.
DR   PANTHER; PTHR10005; SKI ONCOGENE-RELATED; 1.
DR   PANTHER; PTHR10005:SF3; SKI-LIKE PROTEIN; 1.
DR   Pfam; PF08782; c-SKI_SMAD_bind; 1.
DR   Pfam; PF02437; Ski_Sno; 1.
DR   SMART; SM01046; c-SKI_SMAD_bind; 1.
DR   SUPFAM; SSF46955; Putative DNA-binding domain; 1.
DR   SUPFAM; SSF63763; SAND domain-like; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053286}.
FT   DOMAIN          264..359
FT                   /note="c-SKI SMAD4-binding"
FT                   /evidence="ECO:0000259|SMART:SM01046"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          433..461
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          480..507
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          543..600
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          631..686
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        446..461
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         689
FT                   /evidence="ECO:0000313|EMBL:KFM08395.1"
SQ   SEQUENCE   689 AA;  78131 MW;  334CBA779DF9692C CRC64;
     MESPQINFPL GLVSDQKRSG IQEDGSPPLK KAMTEMHVNS KVRVVINKLP TIKKENLDEY
     DETPVEADGE TAKPNNTSLS EPLNLNPGLK HTLAQFHLSS QSSLGGPAAF SARYSQESMS
     PTVFLPLPSP QILSGPLLIP PDSSTELTQT ILEGESISCF KVGGEKRLCL PQVLNSVLRD
     FSLQQINTVC DELYIYCSRC TSDQLHILKV LGILPFNAPS CGLITLTDAQ RLCNALLRPR
     TFPQNGSFLP GKNTLAQLKE TGSAFEVEHE CLGKCQGLFA PQFYLAPDDP CIQCLECYGM
     FSPQTFVMHS HRSPDKRTCH WGFESAKWHC YLHINQKYLG TSEERELKHL LEEMKEKFSE
     KNQKRTQSKV NSQQSLEVSQ WYPVIKQEAE TDPQPPSFFH PSYYLYMCDK VVAPNVSLAS
     QYKDVAKTAV KASEVIKSSP GQSEKKLSSG KHKKAASYPE LSLEEQEKID LKTGVEQHKR
     LDLPVSARSA RGGKSERVSS KITRDSSRVE VGNDVRTLSP TLMKDISCED DKGRIMEEVM
     KTYVKQQEKL NTILRRKQQL QMEVEMLSNS KAMKELTEEQ QNLQKELECL QAEHAQRMEE
     FYFEQRDLEK KLDQVMKQKC SCDSNLEKDK EAEYAAQLAE LRQRLDHAEA DRQELQDELR
     QEREAREKLE MMIKELKLQI LKSSKNGKG
//