ID   A0A087R4X7_APTFO        Unreviewed;       823 AA.
AC   A0A087R4X7;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Transmembrane protein 63C {ECO:0000313|EMBL:KFM08531.1};
DE   Flags: Fragment;
GN   ORFNames=AS27_04496 {ECO:0000313|EMBL:KFM08531.1};
OS   Aptenodytes forsteri (Emperor penguin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC   Aptenodytes.
OX   NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM08531.1, ECO:0000313|Proteomes:UP000053286};
RN   [1] {ECO:0000313|EMBL:KFM08531.1, ECO:0000313|Proteomes:UP000053286}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM08531.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC       {ECO:0000256|ARBA:ARBA00007779}.
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DR   EMBL; KL226108; KFM08531.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A087R4X7; -.
DR   STRING; 9233.A0A087R4X7; -.
DR   Proteomes; UP000053286; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR   InterPro; IPR045122; Csc1-like.
DR   InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR   InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR   InterPro; IPR032880; Csc1/OSCA1-like_N.
DR   PANTHER; PTHR13018:SF21; CALCIUM PERMEABLE STRESS-GATED CATION CHANNEL 1; 1.
DR   PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR   Pfam; PF14703; PHM7_cyt; 1.
DR   Pfam; PF02714; RSN1_7TM; 1.
DR   Pfam; PF13967; RSN1_TM; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053286};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        49..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        197..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        417..441
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        461..484
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        505..528
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        611..641
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        662..684
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        696..717
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          49..215
FT                   /note="CSC1/OSCA1-like N-terminal transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF13967"
FT   DOMAIN          231..409
FT                   /note="CSC1/OSCA1-like cytosolic"
FT                   /evidence="ECO:0000259|Pfam:PF14703"
FT   DOMAIN          421..678
FT                   /note="CSC1/OSCA1-like 7TM region"
FT                   /evidence="ECO:0000259|Pfam:PF02714"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFM08531.1"
FT   NON_TER         823
FT                   /evidence="ECO:0000313|EMBL:KFM08531.1"
SQ   SEQUENCE   823 AA;  94153 MW;  D4F93909CD81015C CRC64;
     EPAPGGAGPT SLDVLSFLDA LVNSTEEQCF SARSRSTVLE GLPFGGVPTV LAINFILWLL
     LLLVFSCLRK AAWDYGRLAL LMDNDSLTSL FYGEQSEKEK SPSESSPLDI DNKDVGFCSW
     LISIYQMKDE EIQSKCGIDA TTYLSFQRHL LVLLMLVCVL SVAVILPVNF SGDLLGHNPT
     HFGRTTIANI PTQDRLLWLH SIFALIYFIL TILCMAHHSV HLEYRENEKV ARTLMVTHIP
     KEITDPSLII KHFHEAYPSC TVTNVQFCFD VRKLMKLDAE RRKAMKGRLY FTTKAQKEGK
     IMIKTHPCAR IFCCRFCGFE QVDAEQYYGE LEEKLTDEFN AERNRIMLKR LDMAFVTFQD
     ERMTAVILKD YSHIRCRKHP QQSSVTTVVK SHHWGVRYAP APSDIIWENL SVRGTSWWVR
     FILLNICLFV LLFFLTTPAI IVNTMDMFNV TQPVESLKNP IITQFFPTLL LWAFSVFLPF
     LVYYSAFFES HWTRSSENQL TMHKCFFFLV FMVIILPSLG LSSLDLFFRW LFDTHFLDEA
     DIKFQCVFLP DNGAFFVNYV VTSSLIGTAM ELLRIPGLLV YTARLCFAKS EPERLHVKRS
     QAYQFQFGLE YAWTCCIFSV VMTYSITCPI IVPFGLLYML LKHMVDRYNI YYVYIPTKLN
     QRLHVAAISQ VVVAPILCMF WLLFFSVLRL GPTRPVTLFT FVVLLSCIIF SFFGLCLKKL
     QPRKPSSYQM SDQSEGTFND VERSSVSSTP NSNLFVATVL QEPELSLTPA ASPAHQCYGT
     MGNHLEPVED GEDGGLQSFE TELETVEGEY RSGPVMESQA RYQ
//