ID A0A087R6V3_APTFO Unreviewed; 682 AA.
AC A0A087R6V3;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Calpain-9 {ECO:0000313|EMBL:KFM09207.1};
DE Flags: Fragment;
GN ORFNames=AS27_01469 {ECO:0000313|EMBL:KFM09207.1};
OS Aptenodytes forsteri (Emperor penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC Aptenodytes.
OX NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM09207.1, ECO:0000313|Proteomes:UP000053286};
RN [1] {ECO:0000313|EMBL:KFM09207.1, ECO:0000313|Proteomes:UP000053286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM09207.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00239}.
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DR EMBL; KL226149; KFM09207.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087R6V3; -.
DR STRING; 9233.A0A087R6V3; -.
DR Proteomes; UP000053286; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00214; Calpain_III; 1.
DR CDD; cd00044; CysPc; 1.
DR Gene3D; 2.60.120.380; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR033883; C2_III.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR10183; CALPAIN; 1.
DR PANTHER; PTHR10183:SF385; CALPAIN-9; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00230; CysPc; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000053286};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807}.
FT DOMAIN 42..337
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT DOMAIN 591..626
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT ACT_SITE 97
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1"
FT ACT_SITE 254
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1"
FT NON_TER 682
FT /evidence="ECO:0000313|EMBL:KFM09207.1"
SQ SEQUENCE 682 AA; 78069 MW; 466A96DDFC8B02F0 CRC64;
MPYLYRDSKL RPPALPGAAR ATHSSGKAYK ELKQECLCKG VLFEDPDFPA CNSSLFFSEK
PPIPFIWKRP TDIVKDPKFI LRGATRTDIC QGDLGDCWLL AAIASLTLNE KTLARVVPLD
QNFGPDYAGI FHFQFWQHNE WLDVVIDDRL PTFKGRLVFL HSAEHNEFWS ALLEKAYAKL
NGSYEALKGG STIEAMEDFT GGVGEMYEVK KAPDNFYEIL EKALKICSMV GCSIDTNSVA
ESEAKTPLGL IKGHAYSVTG IDKVRYLGRQ VQLIRIRKPW GQVEWNGPWS DNSPEWRSIS
PLEQRRLSQA ALDDGEFWMK FEDFKVHFDK VEICNLTPDA LEDSTAHKWE VTIHQGSWVR
GSTAGGCRNF LETFWTNPQI KLHLTEKDDG QDDCTFIAAL MQNDRRKLKK LGAEMLTIGY
SIYESSGRDG HLGKDFFRYH PSKARSKTYI NLREVSNRFK LPPGDYVLIP TTFEPHQEAD
FCLRIFSEKK AITEDLDESV AIDLPEPLNP TPSPQETEEE KQFRALFEQI SGKDMEIAAE
ELKYVLNDVL KETKNIKFKN LSLISCRNII SLMDTSGNGK LEFSEFKVFW EKMKKWINIF
LQFDFDKSGS MSSYELRSAL KAAGYQLNNY LLQLIVLRYA DEQFQIEFDD FLNCLIRLEN
ASRVFQALSV KNKEFINLNI GE
//
