ID A0A087RCV7_APTFO Unreviewed; 403 AA.
AC A0A087RCV7;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Muellerian-inhibiting factor {ECO:0000256|ARBA:ARBA00020473};
DE AltName: Full=Anti-Muellerian hormone {ECO:0000256|ARBA:ARBA00030008};
DE AltName: Full=Muellerian-inhibiting substance {ECO:0000256|ARBA:ARBA00031273};
DE Flags: Fragment;
GN ORFNames=AS27_09987 {ECO:0000313|EMBL:KFM11311.1};
OS Aptenodytes forsteri (Emperor penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC Aptenodytes.
OX NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM11311.1, ECO:0000313|Proteomes:UP000053286};
RN [1] {ECO:0000313|EMBL:KFM11311.1, ECO:0000313|Proteomes:UP000053286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM11311.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|ARBA:ARBA00011748}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; KL226296; KFM11311.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087RCV7; -.
DR STRING; 9233.A0A087RCV7; -.
DR Proteomes; UP000053286; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007506; P:gonadal mesoderm development; IEA:UniProtKB-KW.
DR CDD; cd13757; TGF_beta_AMH; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR006799; AMH_N.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR021203; Muellerian-inhibiting_factor.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR15009; MUELLERIAN-INHIBITING FACTOR; 1.
DR PANTHER; PTHR15009:SF4; MUELLERIAN-INHIBITING FACTOR; 1.
DR Pfam; PF04709; AMH_N; 2.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Differentiation {ECO:0000256|ARBA:ARBA00023156};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Gonadal differentiation {ECO:0000256|ARBA:ARBA00023156};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000053286};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 289..403
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 161..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFM11311.1"
FT NON_TER 403
FT /evidence="ECO:0000313|EMBL:KFM11311.1"
SQ SEQUENCE 403 AA; 44428 MW; 7EF3D4E873F69C61 CRC64;
VKWEAQVKLR FKLVFQAEVG RSLGELRFAL LLFYLGSREG PGAGRREELL ATGTGLVREQ
SLCLARDTQY LLLGAAVASV TRTSEQLSFE ASLAIRHRGK GGALLPPTET QQLLFGSDDK
CFTRMTPVLL LLAKSQEEEE EVALAPSSYL SADGVVDVAP YPQLSPPQAG TEELPSPTAP
SQANASSPAP GSSNQFLGIL TQFIRQVLSP SSELPTQPSS HHWLDFQELK DIPAFQANMG
LFQHLLSFCY YPPGPGEGQA GKRPPGSGKL HALLLLKALQ TVRARWQERR KVLRQNRSAR
HQAHCRLQEL TIDLHDRKFI VMPTVYTANN CEGPCKLPLS TRVPSYYSHT VLLLGMQERG
SPLQRAPCCV PVRYSDQLII SLSTEGLEVR KFPNMVAEEC GCR
//