ID A0A087V545_BALRE Unreviewed; 901 AA.
AC A0A087V545;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 03-MAY-2023, entry version 35.
DE RecName: Full=hexokinase {ECO:0000256|ARBA:ARBA00012324};
DE EC=2.7.1.1 {ECO:0000256|ARBA:ARBA00012324};
DE Flags: Fragment;
GN ORFNames=N312_07312 {ECO:0000313|EMBL:KFO07737.1};
OS Balearica regulorum gibbericeps (East African grey crowned-crane).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gruiformes; Gruidae; Balearica.
OX NCBI_TaxID=100784 {ECO:0000313|EMBL:KFO07737.1, ECO:0000313|Proteomes:UP000053309};
RN [1] {ECO:0000313|EMBL:KFO07737.1, ECO:0000313|Proteomes:UP000053309}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N312 {ECO:0000313|EMBL:KFO07737.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000435};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17826;
CC Evidence={ECO:0000256|ARBA:ARBA00000435};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:22740, ChEBI:CHEBI:4194, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61567, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000417};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22741;
CC Evidence={ECO:0000256|ARBA:ARBA00000417};
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 1/4.
CC {ECO:0000256|ARBA:ARBA00004888}.
CC -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC {ECO:0000256|ARBA:ARBA00005028}.
CC -!- SIMILARITY: Belongs to the hexokinase family.
CC {ECO:0000256|ARBA:ARBA00009225}.
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DR EMBL; KL480315; KFO07737.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087V545; -.
DR UniPathway; UPA00109; UER00180.
DR UniPathway; UPA00242; -.
DR Proteomes; UP000053309; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019318; P:hexose metabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 2.
DR Gene3D; 3.30.420.40; -; 2.
DR Gene3D; 3.40.367.20; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR001312; Hexokinase.
DR InterPro; IPR019807; Hexokinase_BS.
DR InterPro; IPR022673; Hexokinase_C.
DR InterPro; IPR022672; Hexokinase_N.
DR PANTHER; PTHR19443; HEXOKINASE; 1.
DR PANTHER; PTHR19443:SF28; HEXOKINASE HKDC1; 1.
DR Pfam; PF00349; Hexokinase_1; 2.
DR Pfam; PF03727; Hexokinase_2; 2.
DR PRINTS; PR00475; HEXOKINASE.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 4.
DR PROSITE; PS00378; HEXOKINASE_1; 1.
DR PROSITE; PS51748; HEXOKINASE_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KFO07737.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053309};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2..204
FT /note="Hexokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00349"
FT DOMAIN 211..444
FT /note="Hexokinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03727"
FT DOMAIN 455..652
FT /note="Hexokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00349"
FT DOMAIN 658..892
FT /note="Hexokinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03727"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO07737.1"
FT NON_TER 901
FT /evidence="ECO:0000313|EMBL:KFO07737.1"
SQ SEQUENCE 901 AA; 100222 MW; B536A370C19C68E5 CRC64;
QVDRYLYHMR LSDDVLLDVM TRFQAEMVKG LGKDTNPTAT VKMLPTFVRS LPDGSEKGDF
LAVDLGGSQF RAHQVKVFDD GKQSSQLESK FYPTPKEVIQ GNGAELFDYV ADCLLDFMET
KNLKNKKLPL GFTFSFPCKQ TKLEEGVLLA WTKHFKVRGV QDTDVVNSLR KALQKHKASF
APARDVDVLA LVNDTVGTMM TCGYDDQRCE VGVIIGTGTN ACYMEEMRHI DLVEGDEGRM
CINTEWGAFG DDGALDDLRT EFDRELDLGS LNPGKQLFEK MISSLYLGEL VRLILLKMTK
EGLLFNGKVS TALLTKGKIE MKHVSAMEKY KEGLSNTKEI LTELNLFPSE EDCIAVQHVC
TIVSFRSANL CAAALAAILT RLRENKKLLR MRTTVGIDGG LYKTHPQYAK RLHKVVRRLV
PNCDVRFLLS VSGSGKGAAM VTAVAYRLAA QRKQIDAALA PFLLSLETLR EVKNKMRTEL
EYGLKRETQA SATVKMLPTY VCGTPDGTEK GKFLALDLGG TNFRVLLVKI RSGRRRSVQM
YNKIFAIPLE IMQGTGEELF DHIVQCIADF LEYMGIKGAR LPLGFTFSFP CRQASIDKGT
LVGWTKGFKA TDCEGEDVVD MLREAIRRRN EFDLDIVAVV NDTVGTMMTC GYEDPNCEIG
LIAGTGSNVC YMEDMKNIEI VEGNEGKMCI NTEWGGFGDN GCIDNIRTKY DKEVDEGSLN
PGKQRYEKMT SGMYLGEIVR QILIDLTKQG LLFRGQISES LRKRGIFETK FLSQIESDRL
ALLQVRRILQ QLGLDSTCED SIIVKEVCGA VSKRAAQLCG AGLAAIVEKK RENRGVEHLQ
ITVGVDGTLY KLHPHFSRVL RETVKELAPQ CDVTFMLSED GSGKGAALIT AVAKRLHNVG
Q
//
