ID A0A087V807_BALRE Unreviewed; 778 AA.
AC A0A087V807;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Tyrosine-protein kinase transmembrane receptor ROR2 {ECO:0000313|EMBL:KFO08749.1};
DE Flags: Fragment;
GN ORFNames=N312_06061 {ECO:0000313|EMBL:KFO08749.1};
OS Balearica regulorum gibbericeps (East African grey crowned-crane).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gruiformes; Gruidae; Balearica.
OX NCBI_TaxID=100784 {ECO:0000313|EMBL:KFO08749.1, ECO:0000313|Proteomes:UP000053309};
RN [1] {ECO:0000313|EMBL:KFO08749.1, ECO:0000313|Proteomes:UP000053309}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N312 {ECO:0000313|EMBL:KFO08749.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00121}.
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DR EMBL; KL483335; KFO08749.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087V807; -.
DR Proteomes; UP000053309; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR CDD; cd07468; CRD_TK_ROR2; 1.
DR CDD; cd00108; KR; 1.
DR CDD; cd05091; PTKc_Ror2; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 2.40.20.10; Plasminogen Kringle 4; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000001; Kringle.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR018056; Kringle_CS.
DR InterPro; IPR038178; Kringle_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR016247; Tyr_kinase_rcpt_ROR.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR PANTHER; PTHR24416:SF132; TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR2; 1.
DR Pfam; PF01392; Fz; 1.
DR Pfam; PF00051; Kringle; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PIRSF; PIRSF000624; TyrPK_TMrec_ROR; 1.
DR PRINTS; PR00018; KRINGLE.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00130; KR; 1.
DR SUPFAM; SSF57440; Kringle-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS00021; KRINGLE_1; 1.
DR PROSITE; PS50070; KRINGLE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRSR:PIRSR000624-
KW 2}; Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Kinase {ECO:0000313|EMBL:KFO08749.1};
KW Kringle {ECO:0000256|ARBA:ARBA00022572, ECO:0000256|PROSITE-
KW ProRule:PRU00121}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000624-2};
KW Receptor {ECO:0000313|EMBL:KFO08749.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053309};
KW Transferase {ECO:0000313|EMBL:KFO08749.1};
KW Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|EMBL:KFO08749.1};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 239..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..139
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 151..230
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 309..582
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 593..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 690..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..623
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..718
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 743..778
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 451
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000624-1"
FT BINDING 315..323
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000624-2"
FT BINDING 343
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000624-2"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO08749.1"
FT NON_TER 778
FT /evidence="ECO:0000313|EMBL:KFO08749.1"
SQ SEQUENCE 778 AA; 87613 MW; 7DDF4498FEEEA708 CRC64;
REDYHEDGFC QPYRGIACAR IIGNRTIYVD SLQMQGEIEN RITAAFTMIG TSTHLSDQCS
QFAIPSFCHF VFPLCDERSR TPKPRELCRD ECEVLENDLC RQEYNIARSN PLILMQLQLP
KCEDLPRPDT LEAANCIRIG IPVERLSRYH QCYNGSGVDY RGTVSVTKSG HSCQLWDSQS
PHSHDLTSTQ FPELGGGHAY CRNPGGQMDG PWCFTKNKNV RMELCDIPSC SPRDNSKMGI
LYILVPSIAI PLVIACLFFL VCMCRNKQKA SAATPQRRQL MASPSQDMEM PLINQHKQAK
LKEINLSTVR FMEELGEERF GKVYKGHLFG TAPGEQTQAV AIKTLKDKAE LALREEFKHE
AMMRSRLQHP NIVCLLGIVT KEQPISMIFS YCSHSDLHEF LVMRSPHSDV GSTDDDKTVK
STLEPADFFH IVTQIAAGME YLSSHHVVHK DLATRNILVF DKLNVKISDL GLFREVYAAD
YYKLMGNSLL PIRWMSPEAI MYGKFSIDSD IWSYGVVLWE VFSYGLQPYC GYSNQDVIEM
IRNRQVLPCP DDCPTWIYTL MLECWNEFPN RRPRFKDIHN RLRTWGNLSN YNSSAQTSGA
SNTTQTSSLS TSPVSNVSNA RYIGPKQKTP AFPQPQFIQM KGQMRPMVPP PQLYIPVNGY
QPMPAYGAYL PNFYPVQIPM QMAPQQMPPQ IIPKPGSHHS GSGSTSTGYV TTAPSNASVA
DRAALLSEGT DDTHNGTEDI AQNPVQEEEE EEGSVPETEL LGDNDTLQMD EAEIQSEA
//
