ID A0A087VE73_BALRE Unreviewed; 856 AA.
AC A0A087VE73;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Leucine-rich repeat-containing protein 8D {ECO:0000313|EMBL:KFO10915.1};
GN ORFNames=N312_04488 {ECO:0000313|EMBL:KFO10915.1};
OS Balearica regulorum gibbericeps (East African grey crowned-crane).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gruiformes; Gruidae; Balearica.
OX NCBI_TaxID=100784 {ECO:0000313|EMBL:KFO10915.1, ECO:0000313|Proteomes:UP000053309};
RN [1] {ECO:0000313|EMBL:KFO10915.1, ECO:0000313|Proteomes:UP000053309}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N312 {ECO:0000313|EMBL:KFO10915.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823,
CC ChEBI:CHEBI:17996; Evidence={ECO:0000256|ARBA:ARBA00024167};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=iodide(out) = iodide(in); Xref=Rhea:RHEA:66324,
CC ChEBI:CHEBI:16382; Evidence={ECO:0000256|ARBA:ARBA00024145};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=taurine(out) = taurine(in); Xref=Rhea:RHEA:66328,
CC ChEBI:CHEBI:507393; Evidence={ECO:0000256|ARBA:ARBA00024158};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LRRC8 family.
CC {ECO:0000256|ARBA:ARBA00010471}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL489959; KFO10915.1; -; Genomic_DNA.
DR RefSeq; XP_010300816.1; XM_010302514.1.
DR AlphaFoldDB; A0A087VE73; -.
DR GeneID; 104635638; -.
DR KEGG; breg:104635638; -.
DR CTD; 55144; -.
DR OrthoDB; 55205at2759; -.
DR Proteomes; UP000053309; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR021040; LRRC8_Pannexin-like.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF3; LEUCINE RICH REPEAT CONTAINING 8 VRAC SUBUNIT A; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF12534; Pannexin_like; 1.
DR SMART; SM00365; LRR_SD22; 4.
DR SMART; SM00369; LRR_TYP; 8.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 4.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053309};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..382
FT /note="LRRC8 pannexin-like TM region"
FT /evidence="ECO:0000259|Pfam:PF12534"
FT REGION 63..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 856 AA; 97509 MW; CA01A48055FF2784 CRC64;
MFTLAEVASL NDIQPTYRIL KPWWDVFMDY LAVVMLMVAI FAGTMQLTKD QVVCLPVLQS
TVNSKAQPGT SGKADFTTVE TTTGQGEEAS MRTVSFGSAP TVTPDVPLSR ATSPQYQPTE
SGQELKKEQK DSSGRKTNLD FQQYVFINQM CYHLALPWYS KYFPYLVLIH TIILIVSSNF
WFKYPKTCSK IEHFVSILGK CFESPWTTKA LSETACEDSE ENKQRLTGAQ SLPKYVSTSS
DEGSPSASTP MITKSGFKFS ADKPMIEVPS VTILDKKDGE QAKALFEKVR KFRAHVEDSD
LIYKLYVGQT VIKTVKFIFI LCYTANFVNT ISFEHICNPK VEHLIGYTQF ECTHNMAYML
KKLLISYISL ICVYGFICLY TLFWLFRIPL KEYSFEKVRE ESSFSDIPDV KNDFAFLLHM
VDQYDQLYSK RFGVFLSEVS ENKLREISLN HEWTFEKLRQ HVSRNAQDKQ ELHLFMLSGV
PDAVFDLTDL DVLKLELIPE AKIPAKISQM TNLQELHLCH CPAKVEQTAF SFLRDHLRCL
HVKFTDVAEI PAWVYLLKNL RELYLIGNLN SENNKMIGLE SLRELRHLKI LHVKSNLTKI
PPNITDVAPH LTKLVIHNDG TKLVVLNSLK KMTNVAELEL QNCELERIPH AIFSLSNLQE
LDLKSNSIRT IEEIISFQHL KRLTCLKLWH NKIVSIPSSI THIKNLESLY LSNNKLESLP
AAVFSLQKLR CLDVSYNSIA LIPVEIGLLQ NLQHFHITGN KVDILPKQLF KCVKLRTLSL
GQNCITSIPD KVSQLLQLTH LELKGNCLDR LPATLGQCQL LRKSGLVVED HLFDALPSEV
KEVLNQDTSI PFANGI
//