ID A0A087VH54_BALRE Unreviewed; 866 AA.
AC A0A087VH54;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Endothelial PAS domain-containing protein 1 {ECO:0000313|EMBL:KFO11946.1};
DE Flags: Fragment;
GN ORFNames=N312_01825 {ECO:0000313|EMBL:KFO11946.1};
OS Balearica regulorum gibbericeps (East African grey crowned-crane).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gruiformes; Gruidae; Balearica.
OX NCBI_TaxID=100784 {ECO:0000313|EMBL:KFO11946.1, ECO:0000313|Proteomes:UP000053309};
RN [1] {ECO:0000313|EMBL:KFO11946.1, ECO:0000313|Proteomes:UP000053309}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N312 {ECO:0000313|EMBL:KFO11946.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KL493181; KFO11946.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087VH54; -.
DR Proteomes; UP000053309; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR CDD; cd19728; bHLH-PAS_HIF2a_PASD2; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR014887; HIF-1_CTAD.
DR InterPro; IPR021537; HIF_alpha-like.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR013655; PAS_fold_3.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR23043:SF8; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR Pfam; PF11413; HIF-1; 1.
DR Pfam; PF08778; HIF-1a_CTAD; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF08447; PAS_3; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW Hydroxylation {ECO:0000256|ARBA:ARBA00023278};
KW Reference proteome {ECO:0000313|Proteomes:UP000053309};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 6..59
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 84..139
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 240..291
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 442..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 603..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 603..621
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 394
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000256|PIRSR:PIRSR621537-50"
FT MOD_RES 518
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000256|PIRSR:PIRSR621537-50"
FT MOD_RES 843
FT /note="(3S)-3-hydroxyasparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR621537-50"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO11946.1"
FT NON_TER 866
FT /evidence="ECO:0000313|EMBL:KFO11946.1"
SQ SEQUENCE 866 AA; 97000 MW; D61A097701034146 CRC64;
RSSSERRKEK SRDAARCRRS KETEVFYELA HELPLPHNIS SHLDKASIMR LAISFLRTHK
LLSSVCADNE NELEADQQMD NLYLKALEGF IAVVTQDGDM IFLSENVNKY MGLTQVELTG
HSIFDFTHPC DHEEIRENLS LKNGPGFGKK SKEMSTERDF FMRMKCTVTN RGRTVNLKSA
TWKVLHCTGQ VKVYNACPPH TLCGYKEPLP TCLIIMCEPI QHPSNIDIPL DSKTFLSRHS
MDMKFTYCDD RITELIGYHP EELLGRSAYE FYHALDSESM TKSHQNLCTK GQVVTGQYRM
LAKHGGYVWL ETQGTVIYNT RNLQPQCIVC VNYVLSEIEK NDVVFSMDQT ESLFKPHLLT
MSTAYENSIP VTEKSDFLFT KFKEEPEELA QLAPTPGDAI ISLDFGTQKF EEAPAFTSAV
LTPNKAWPVE VKSRAAQGET LTIPSFTMPQ IAPGSSTPSA SSNSSCSTPS SPGDYYSSVD
EDLKIEVIEK LFAMDTESKS QCNSQTDFNE LDLETLAPYI PMDGEDFQLS PICQEECPLS
ESAQNTQQSL SSMSTIFQPL ASASQNQFLP EKYYPQLSNK NINPGHGSLS SVFFNNASRS
SLPPYHDQAS TPLSSMGGRP NTQWPPDPPL EYVPAKWRLM DKYSGSLSSS PSGPPVHSPI
MPIYKKRPLD AFGQRGIDIN PARIALSNSL KLKRQLDYEE QVLQQLSGGD PSVINPSHLM
WKRMKFLKGE NSSLVTEKKS LSTSVLTDEF VCNNSRGLSQ PMNQLQQQQQ QQPTTCGSPV
FICVIYEENP SLPFMSIKLN TFLPWRSSHP PSILLSCMTS RLLGPSFEPY LLPELTRYDC
EVNVPVSGSS TLLQGSELLR ALDQAT
//
