ID A0A087VHD1_BALRE Unreviewed; 249 AA.
AC A0A087VHD1;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Ankyrin repeat and SOCS box protein 8 {ECO:0000256|ARBA:ARBA00017640};
DE Flags: Fragment;
GN ORFNames=N312_07552 {ECO:0000313|EMBL:KFO12023.1};
OS Balearica regulorum gibbericeps (East African grey crowned-crane).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gruiformes; Gruidae; Balearica.
OX NCBI_TaxID=100784 {ECO:0000313|EMBL:KFO12023.1, ECO:0000313|Proteomes:UP000053309};
RN [1] {ECO:0000313|EMBL:KFO12023.1, ECO:0000313|Proteomes:UP000053309}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N312 {ECO:0000313|EMBL:KFO12023.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be a substrate-recognition component of a SCF-like ECS
CC (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex
CC which mediates the ubiquitination and subsequent proteasomal
CC degradation of target proteins. {ECO:0000256|ARBA:ARBA00003062}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; KL493466; KFO12023.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087VHD1; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000053309; Unassembled WGS sequence.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd03727; SOCS_ASB8; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037332; ASB8_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR24134:SF30; ANKYRIN REPEAT AND SOCS BOX PROTEIN 8; 1.
DR PANTHER; PTHR24134; ANKYRIN REPEAT-CONTAINING PROTEIN DDB_G0279043; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00248; ANK; 4.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000053309}.
FT REPEAT 13..45
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 46..77
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 78..110
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 111..143
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 196..249
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO12023.1"
FT NON_TER 249
FT /evidence="ECO:0000313|EMBL:KFO12023.1"
SQ SEQUENCE 249 AA; 27388 MW; CC15F957A0FEAC4D CRC64;
VLSQGADVNC MHGTLKPLHC ACMVADADCV ELLLQKGAEV NALDGYNRTA LHYAAEKDET
CVEILLEYGA NPNALDGNKD TPLHWAAFKN NAECVRSLLE NGALVNARDY NNDTPLSWAA
MKGNLESVSI LLDFGAEVRV VNLKGQTPIS RLVALLVRGL GTEREDSCFD LLHRAIGHFE
LRKNGSMPWE VTRDPQLCEK LTLLCSVPGT LQTLSRYAVR RSLGVRFLPE AVKQLPLPTC
LKEYVLLLS
//
