ID A0A087VJG1_BALRE Unreviewed; 1111 AA.
AC A0A087VJG1;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Thrombospondin-1 {ECO:0000313|EMBL:KFO12753.1};
DE Flags: Fragment;
GN ORFNames=N312_01584 {ECO:0000313|EMBL:KFO12753.1};
OS Balearica regulorum gibbericeps (East African grey crowned-crane).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gruiformes; Gruidae; Balearica.
OX NCBI_TaxID=100784 {ECO:0000313|EMBL:KFO12753.1, ECO:0000313|Proteomes:UP000053309};
RN [1] {ECO:0000313|EMBL:KFO12753.1, ECO:0000313|Proteomes:UP000053309}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N312 {ECO:0000313|EMBL:KFO12753.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thrombospondin family.
CC {ECO:0000256|ARBA:ARBA00009456}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL495693; KFO12753.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087VJG1; -.
DR Proteomes; UP000053309; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.200; -; 2.
DR Gene3D; 6.20.200.20; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 3.
DR Gene3D; 4.10.1080.10; TSP type-3 repeat; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR003367; Thrombospondin_3-like_rpt.
DR InterPro; IPR017897; Thrombospondin_3_rpt.
DR InterPro; IPR008859; Thrombospondin_C.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR028974; TSP_type-3_rpt.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR10199; THROMBOSPONDIN; 1.
DR PANTHER; PTHR10199:SF78; THROMBOSPONDIN-1; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF00090; TSP_1; 3.
DR Pfam; PF02412; TSP_3; 7.
DR Pfam; PF05735; TSP_C; 1.
DR Pfam; PF00093; VWC; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00209; TSP1; 3.
DR SMART; SM00210; TSPN; 1.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF103647; TSP type-3 repeat; 3.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 3.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS50092; TSP1; 3.
DR PROSITE; PS51234; TSP3; 4.
DR PROSITE; PS51236; TSP_CTER; 1.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00634}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Reference proteome {ECO:0000313|Proteomes:UP000053309};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 305..362
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 536..576
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 635..679
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 716..751
FT /note="TSP type-3"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT REPEAT 775..810
FT /note="TSP type-3"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT REPEAT 872..907
FT /note="TSP type-3"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT REPEAT 908..943
FT /note="TSP type-3"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT DOMAIN 947..1111
FT /note="TSP C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51236"
FT REGION 713..733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 824..933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 827..857
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 872..886
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 910..925
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO12753.1"
FT NON_TER 1111
FT /evidence="ECO:0000313|EMBL:KFO12753.1"
SQ SEQUENCE 1111 AA; 122525 MW; 798BAF3D2A10A987 CRC64;
SDLSAESRSD DNSVFDLFEL IGFIRKGAGR RAPGVHLVKG PESSSPAYRI EDASRIPAVP
DSKFQDLLDA IHAEKGFILL ATLRQAKKSR GTLLSVEQKD GSGHVFSLVS NGKAGTLDLS
LSGDGKQQLV SVEDALLATG HWKNITLFVQ EDRAQLYVGC EKMENAELDI PIQNIFTRDL
ASSARLRIAK GGVNDNFQGL LQNVRFVFGT TLETILRNKG CSSSTSAIIT LDNPINGSSP
AIRTNYIGHK TKDIQAVCGF SCDELTNMFV ELQGLRSMVT TLQDRVRKVT EENELIAKVV
QITPGVCIHN GILHKNKEEW TIDSCTECTC QNSATICRKV SCPLMPCSNA TVPDGECCPR
CWPSDYADDG WSPWSEWTSC SVTCGNGIQQ RGRSCDSLNN RCEGSSVQTR TCHLQECDKR
FKQDGGWSHW SPWSSCSVTC GTGIITRIRL CNSPVPQLNG KPCEGEAREN KPCQKDPCPI
NGNWGPWSPW DACTVTCGGG LQKRSRLCNN PEPQYGGKTC VGEARGTQVC NKQDCPIDGC
LSNPCFAGTT CTSSPDGSWK CGACPAGYHG DGVHCQDIDE CKEVPDACFV FNGVHRCENT
EPGYNCLPCP PRFTGTQPFG RSVEDAMANK QVCKPRNPCT DGTHDCNKNA KCNYLGHFSD
PMYRCECKPG YAGNGIICGE DTDLDGWPNE NLVCVANATY HCKKDNCPNL PNSGQEDYDK
DGIGDACDND DDDDGIPDDR DNCPFIYNPQ QYDYDRDDVG DRCDNCPYNH NPDQTDTDNN
GEGDACAVDI DGDGVLNERD NCQYVYNVDQ RDTDLDGVGD QCDNCPLEHN PDQEDTDSDR
IGDQCDNNQD IDEDGHQNNL DNCPYVPNAN QADHDKDGKG DACDHDDDND GMPDDKDNCR
LVANPDQADS DGDGRGDACK DDFDQDSVPD IDDICPENVD ISETDFRRFQ MIPLDPKGTS
QNDPNWVVRH QGKELVQTVN CDPGLAVGFD EFNAVDFSGT FFINTERDDD YAGFVFGYQS
SSRFYVVMWK QITQSYWDST PTKAQGYSGL SIKVVNSTTG PGEHLRNALW HTGNTPGQVR
TLWHDPRHIG WKDFTAYRWR LSHRPKTGYI R
//
