ID A0A087WR34_MOUSE Unreviewed; 119 AA.
AC A0A087WR34;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Non-histone chromosomal protein HMG-17 {ECO:0000256|ARBA:ARBA00040304};
DE AltName: Full=High mobility group nucleosome-binding domain-containing protein 2 {ECO:0000256|ARBA:ARBA00042290};
DE Flags: Fragment;
GN Name=Gm20379 {ECO:0000313|Ensembl:ENSMUSP00000140453.2,
GN ECO:0000313|MGI:MGI:5012564};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000140453.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000140453.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000140453.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000140453.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000140453.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Binds to the inner side of the nucleosomal DNA thus altering
CC the interaction between the DNA and the histone octamer. May be
CC involved in the process which maintains transcribable genes in a unique
CC chromatin conformation. {ECO:0000256|ARBA:ARBA00037490}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the HMGN family.
CC {ECO:0000256|ARBA:ARBA00007696}.
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DR STRING; 10090.ENSMUSP00000140453; -.
DR PaxDb; 10090-ENSMUSP00000140453; -.
DR ProteomicsDB; 369486; -.
DR Antibodypedia; 44621; 64 antibodies from 13 providers.
DR Ensembl; ENSMUST00000188317.2; ENSMUSP00000140453.2; ENSMUSG00000100622.2.
DR AGR; MGI:5012564; -.
DR MGI; MGI:5012564; Gm20379.
DR VEuPathDB; HostDB:ENSMUSG00000100622; -.
DR eggNOG; ENOG502S5FK; Eukaryota.
DR GeneTree; ENSGT00950000182802; -.
DR HOGENOM; CLU_141985_0_0_1; -.
DR InParanoid; A0A087WR34; -.
DR OMA; VYPCSAP; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; A0A087WR34; Protein.
DR Bgee; ENSMUSG00000100622; Expressed in epiblast (generic) and 46 other cell types or tissues.
DR GO; GO:0000785; C:chromatin; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0031492; F:nucleosomal DNA binding; IEA:InterPro.
DR GO; GO:0006325; P:chromatin organization; IBA:GO_Central.
DR InterPro; IPR000079; HMGN_fam.
DR PANTHER; PTHR23087:SF13; NON-HISTONE CHROMOSOMAL PROTEIN HMG-17; 1.
DR PANTHER; PTHR23087; NONHISTONE CHROMOSOMAL PROTEIN HMG; 1.
DR Pfam; PF01101; HMG14_17; 1.
DR PRINTS; PR00925; NONHISHMG17.
DR SMART; SM00527; HMG17; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT REGION 1..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..97
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000140453.2"
SQ SEQUENCE 119 AA; 12853 MW; 8E567CFD11E856BF CRC64;
XSRVKNQRGR PHTHTDQTRA AVYPVYPCSA PTSPATTMSK RKAKGDAKGD KTKVKDKPQR
PERLSAKPAP PKPEPTPKKA PEKKGEKVPK GRKGKANAGK DANNPAENGD AKRDQAQKA
//
