ID A0A087WVK5_HUMAN Unreviewed; 265 AA.
AC A0A087WVK5;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=RUN and SH3 domain containing 1 {ECO:0000313|Ensembl:ENSP00000479495.1};
DE Flags: Fragment;
GN Name=RUSC1 {ECO:0000313|Ensembl:ENSP00000479495.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000479495.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000479495.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H.,
RA Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C.,
RA Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R.,
RA Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.,
RA Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.,
RA Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R.,
RA Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D.,
RA Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A.,
RA Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S.,
RA Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A.,
RA Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S.,
RA Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A.,
RA Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L.,
RA Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z.,
RA Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C.,
RA Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M.,
RA Langford C.F., Pandian R.D., Porter K.M., Prigmore E.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000479495.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL139410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A087WVK5; -.
DR SMR; A0A087WVK5; -.
DR MassIVE; A0A087WVK5; -.
DR PeptideAtlas; A0A087WVK5; -.
DR Antibodypedia; 34192; 146 antibodies from 23 providers.
DR Ensembl; ENST00000489860.5; ENSP00000479495.1; ENSG00000160753.17.
DR UCSC; uc057lqb.1; human.
DR HGNC; HGNC:17153; RUSC1.
DR VEuPathDB; HostDB:ENSG00000160753; -.
DR GeneTree; ENSGT00900000141033; -.
DR HOGENOM; CLU_017252_0_0_1; -.
DR OMA; AQEDFPC; -.
DR ChiTaRS; RUSC1; human.
DR Proteomes; UP000005640; Chromosome 1.
DR Bgee; ENSG00000160753; Expressed in right hemisphere of cerebellum and 191 other cell types or tissues.
DR ExpressionAtlas; A0A087WVK5; baseline and differential.
DR CDD; cd17701; RUN_RUSC1; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR047341; RUN_RUSC1.
DR InterPro; IPR047343; RUSC1_2.
DR PANTHER; PTHR15591:SF11; AP-4 COMPLEX ACCESSORY SUBUNIT RUSC1; 1.
DR PANTHER; PTHR15591; RUN AND SH3 DOMAIN CONTAINING; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR PROSITE; PS50826; RUN; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:A0A087WVK5,
KW ECO:0007829|MaxQB:A0A087WVK5};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 53..197
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT REGION 237..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 265
FT /evidence="ECO:0000313|Ensembl:ENSP00000479495.1"
SQ SEQUENCE 265 AA; 28495 MW; 311307E0FD0B906A CRC64;
MAEAQSGTGQ LQEQKKGLLI AVSVSVDKII SHFGAARNLV QKAQLGDSRL SPDVGHLVLT
TLCPALHALV ADGLKPFRKD LITGQRRSSP WSVVEASVKP GSSTRSLGTL YSQVSRLAPL
SSSRSRFHAF ILGLLNTKQL ELWFSSLQED AGLLSLLYLP TGFFSLARGG CPSLSTELLL
LLQPLSVLTF HLDLLFEHHH HLPLGPPQAP APPGPPPALQ QTMQAMLHFG GRLAQSLRGT
SKEAASDPSD SPNLPTPGSW WEQLT
//
