ID A0A087X689_POEFO Unreviewed; 734 AA.
AC A0A087X689;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Phosphatidylinositol 3-kinase regulatory subunit alpha {ECO:0000256|ARBA:ARBA00013911};
DE AltName: Full=Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha {ECO:0000256|ARBA:ARBA00031433};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000001292.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000001292.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3K p85 subunit family.
CC {ECO:0000256|ARBA:ARBA00009442}.
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DR EMBL; AYCK01017078; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A087X689; -.
DR STRING; 48698.ENSPFOP00000001292; -.
DR Ensembl; ENSPFOT00000001295.2; ENSPFOP00000001292.1; ENSPFOG00000001009.2.
DR eggNOG; KOG4637; Eukaryota.
DR GeneTree; ENSGT00940000155553; -.
DR OMA; EMIDVQV; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd12924; iSH2_PIK3R1; 1.
DR CDD; cd04388; RhoGAP_p85; 1.
DR CDD; cd09930; SH2_cSH2_p85_like; 1.
DR CDD; cd09942; SH2_nSH2_p85_like; 1.
DR CDD; cd11910; SH3_PI3K_p85alpha; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR044124; ISH2_PIK3R1.
DR InterPro; IPR032498; PI3K_P85_iSH2.
DR InterPro; IPR035591; PI3K_p85alpha_SH3.
DR InterPro; IPR035020; PI3kinase_P85_cSH2.
DR InterPro; IPR035022; PI3kinase_P85_nSH2.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF10; PI3K21B, ISOFORM B; 1.
DR Pfam; PF16454; PI3K_P85_iSH2; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00017; SH2; 2.
DR PRINTS; PR00678; PI3KINASEP85.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00252; SH2; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50001; SH2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 3..79
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 113..306
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 341..436
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 634..728
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT COILED 536..570
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 734 AA; 84170 MW; 3EF71ED27EA2527B CRC64;
MSVEGYQYRA LYEYKKEREE DIDLHVGDIL LVSKGALVAL GHSDGLEQQP QKIGWLPGFN
ETTQEKGDFP GTYVEYVGKK WISPPTPKPR PLRPLPVAPG SFKAEDSDSD QGVCLADLTE
QFFLPETAPP LLTRLLEAIE RKGVDNPTLY RTFTAGGGLE IRQYYDCDPP AAELDQLELP
ALCDGLRRYL QDLPQPIVPA ALHAQMVHAV KAPPTEAANP EECTQLLRRI ASSATLPPQY
WLTLQCLLRH FSRVCQNAPK NQLSARSLGE IFSPVFFRQQ PTSCEPSLDA FIKIIEVLVT
SEWSESQAAP APTALPPKPP KSTAVTNNGM NNNMALQDAE WYWGDISREE VNEKLRDTAD
GTFLVRDAST KMHGDYTLTL RKGGNNKLIK IFHRDGKYGF SDPLTFSSVV ELINHYRNES
LAQYNPKLDV KLLYPVSKHQ QDQVVKEDNI EAVGRKLCEY HQQYQEKNKE YDRLYEEYTR
TSQEIQMKRT AIEAFNETIK IFEEQCQTQE RYSKEYIEKF KREGNDKEIQ RIMGNYEKLK
SRISEIVDSK RRLEEDLKKQ AADYREIDKR MNSIKPDLIQ LRKTRDQYLM WLTQKGVRQK
KLNEWLGIKN ENTEDQYSMV DDDEDLPHHD ERSWRLGNIN RLQAEAVLQG KRDGTFLVRD
SSKAGCYACS VVVEGEVKHC VINKTPSGYG FAEPYNLYGS LKELVLHYQH TSLVQHNDSL
NVTLAYPVYA QQRR
//