ID A0A087XBG9_POEFO Unreviewed; 2477 AA.
AC A0A087XBG9;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Neurogenic locus notch homolog protein 1 {ECO:0000256|ARBA:ARBA00019142};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000003122.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000003122.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NOTCH family.
CC {ECO:0000256|ARBA:ARBA00005847}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AYCK01014201; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 48698.ENSPFOP00000003122; -.
DR Ensembl; ENSPFOT00000003126.1; ENSPFOP00000003122.1; ENSPFOG00000002502.1.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000157157; -.
DR OMA; TCHEQRD; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0050793; P:regulation of developmental process; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 27.
DR CDD; cd21702; JMTM_Notch1; 1.
DR Gene3D; 3.30.300.320; -; 1.
DR Gene3D; 3.30.70.3310; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.10.25.10; Laminin; 35.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR008297; Notch.
DR InterPro; IPR035993; Notch-like_dom_sf.
DR InterPro; IPR022362; Notch_1.
DR InterPro; IPR024600; Notch_C.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR010660; Notch_NOD_dom.
DR InterPro; IPR011656; Notch_NODP_dom.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF22; DROSOPHILA CRUMBS HOMOLOG; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF00008; EGF; 23.
DR Pfam; PF07645; EGF_CA; 5.
DR Pfam; PF12661; hEGF; 2.
DR Pfam; PF06816; NOD; 1.
DR Pfam; PF07684; NODP; 1.
DR Pfam; PF00066; Notch; 3.
DR PIRSF; PIRSF002279; Notch; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR01452; LNOTCHREPEAT.
DR PRINTS; PR01983; NOTCH.
DR PRINTS; PR01984; NOTCH1.
DR SMART; SM00248; ANK; 6.
DR SMART; SM01334; DUF3454; 1.
DR SMART; SM00181; EGF; 36.
DR SMART; SM00179; EGF_CA; 33.
DR SMART; SM00004; NL; 3.
DR SMART; SM01338; NOD; 1.
DR SMART; SM01339; NODP; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 12.
DR SUPFAM; SSF57184; Growth factor receptor domain; 7.
DR SUPFAM; SSF90193; Notch domain; 3.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 23.
DR PROSITE; PS00022; EGF_1; 33.
DR PROSITE; PS01186; EGF_2; 26.
DR PROSITE; PS50026; EGF_3; 36.
DR PROSITE; PS01187; EGF_CA; 10.
DR PROSITE; PS50258; LNR; 3.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Angiogenesis {ECO:0000256|ARBA:ARBA00022657};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Calcium {ECO:0000256|PIRSR:PIRSR002279-1};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR002279-2};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR002279-1};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..2477
FT /note="Neurogenic locus notch homolog protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001832635"
FT TRANSMEM 1735..1757
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..58
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 59..99
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 102..139
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 140..176
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 178..216
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 218..255
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 257..293
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 295..333
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 335..371
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 372..410
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 412..450
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 452..488
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 490..526
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 528..564
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 566..601
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 603..639
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 641..676
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 678..714
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 716..751
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 753..789
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 791..827
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 829..869
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 871..907
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 909..945
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 947..983
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 985..1021
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1023..1059
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1061..1097
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1110..1145
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1147..1183
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1185..1221
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1223..1267
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1269..1307
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1309..1348
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1350..1386
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1389..1427
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1451..1491
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1492..1529
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1530..1573
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT REPEAT 1926..1958
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1993..2025
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 2026..2058
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 2059..2091
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1775..1814
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2126..2184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2337..2477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1776..1791
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2126..2148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2161..2184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2337..2372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2395..2428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2436..2477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 432
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 435
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 452
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 455
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 469
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 470
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 490
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 491
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 493
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 507
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 508
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT DISULFID 48..57
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 89..98
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 129..138
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 166..175
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 206..215
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 245..254
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 283..292
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 323..332
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 361..370
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 381..398
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 400..409
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 416..429
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 423..438
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 440..449
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 456..467
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 461..476
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 478..487
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 494..505
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 499..514
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 516..525
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 554..563
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 570..580
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 591..600
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 629..638
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 645..655
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 666..675
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 704..713
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 720..730
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 741..750
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 779..788
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 817..826
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 838..855
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 897..906
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 935..944
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 973..982
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1011..1020
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1049..1058
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1087..1096
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1135..1144
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1173..1182
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1211..1220
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1257..1266
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1278..1295
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1297..1306
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1338..1347
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1376..1385
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1398..1415
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1417..1426
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2477 AA; 267703 MW; 2CA17E696910A0F1 CRC64;
MYHFLVKLTF LIQAIVFSQG LKCSLPTETC LNGGRCEATS NGDGECKCST DYVGDRCQYP
SPCSPSPCRN GGECHAVSHG NTFDFHCVCR LGFTDRLCLT PRNHACMSSP CRNGGTCDLI
SLSSFRCRCP PGWSGKTCQT PNPCASNPCA NGGQCSALDS MFKCTCPANF QGLTCKQDVN
ECAHNPSPCL NGGFCVNEVG SYHCRCPQEF TGQHCETIYS PCSPSPCQNG GTCVQKGETT
YDCSCLLGFT GQHCEHNIDD CPAHSCQNGG VCVDGVNTYN CQCPPHYTGQ YCTENVDECE
MMPNACQNGG TCHDTHGSYH CVCVNGWTGD DCSENIDDCA SAACYNGATC HDRVASFFCE
CPHGRTGLLC HLDDACISNP CQKGSNCDTN PVNGKAICTC PPGYSGSACN LDIDECSLGA
NPCEHGGRCL NTLGSFQCKC LQGYEGPRCE MDINECISNP CQNDATCLDQ IGGFHCICMP
GYEGVFCHIN TDECASQPCL NNGKCIDKIN SFHCECPKGF SGNLCQVDID ECASTPCKNG
AKCTDGPNKY TCDCAEGYTG QHCEIDINEC YSDPCHYGTC EDGLASFTCY CRPGYTGRLC
ETNINECLSQ PCKNGGTCQD RENSYFCSCP KGTAGSNCEV NLDDCKSQPC DYGRCIDKIN
GYECACEPGY TGTMCNINID DCVINPCQNG GTCVDGVNSF TCICPEGYHD VTCLSEVNEC
ASNPCIHGRC QDLINGYKCT CDSGWSGHNC NINNNECESN PCMNGGICKD MTSGYHCTCR
VGFTGPNCQT NINECASNPC LNQGTCIDDV AGYKCNCLLP YTGENCETLQ APCSPRPCKN
GGICKEAEDY QSFSCICPEG WQAKGQTCEI DINECVKSPC RNGAVCLNTM GGFQCKCQPG
YTGQRCETDI DDCKPNPCSN GGLCRDSVNR FTCTCLPGFR GSRCEHDINE CESNPCKNGA
NCTDCVNSYT CTCPPGFSGI NCEINTNDCT DSSCFNGGTC VDGINTFTCL CLTGFTGSYC
QYDINECDSK PCLNGGTCLD GYGTYKCTCP HGYTGVNCQS LVRWCDSSPC KNGGSCWQQG
ASYTCQCQTE FTGLYCDIPS VSCEVAAKRQ GVDVSQLCRN SGQCLDAGNT HYCRCQAGYT
GSYCQEQVDE CSPNPCQNGA TCNDYLGGYS CECVPGYHGV NCSKEINECQ SQPCQNGGTC
IDLINTYKCS CPRGTQGVHC EINLDDCNPP SDPLTNEPKC FNNGKCVDRI GGYQCLCPPG
YVGERCEGDV NECLSNPCDP RGSYNCIQLP NSYRCECRTG YTGQRCDKVF DGCKGRPCRN
GGTCAVASNT PHGFICKCPP GFTGSSCEYD SRSCGSLSCR NGGTCVSGHL GPRCLCPSTF
TGPECLTPTD SLCISNPCYN GGTCQITPDA PFFQCSCPSN FNGLLCHILD YSFVGGFGRD
ITPPPEVEVS CEISQCDEWA GNHICDSLCN NHACGWDGGD CSLNFDDPWQ NCSAALQCWR
YFNNGKCDGQ CNSPGCLYDG FDCQGQEGQC NPLYDQYCKD HYADGHCDQG CNNAECEWDG
LDCANNMPEK LADGHLVLVV HIPPELLKNR SSSFLRELSN VLHTNVVFRR DAKGEPMVFP
YYGNEQDLVK HNVLKRSAEG WPSMPSNVLG QVKESVSSMV NQRKRRELDP VQVKGSIVYL
EIDNRQCYQQ STECFQSATD VAAFLGALAT SGNLNVPYIE AVTSVKPTPP PTELFPVYLV
LLVLAISGFI CLGVIVVQKR RREHGQLWMP EGFNVSEPSK KKRREPLGED SVGLKPMKNS
DSNLIDDNQT EWGDDDPDCR HFRYEEQAML DLSDHTDQRK WTQQHLDAAD LRITSIAPTP
PQGEIENDCM DVNVRGPDGF TPLMIASCSG GGLDNGNSEE EEDPSAEIIT DFIYHGANLH
NQTDRTGETA LHLAARYARS DAAKRLLESS ADANVQDNMG RTPLHAAVAA DAQGVFQILI
RNRATDLDAR MHDGTTPLIL AARLAVEGMV EELINCHADA NATDDSGKSA LHWAAAVNNV
EAAVMLLKNG ANKDMQDNKE ETPLFLAARE GSYETAKVLL EHFANREITD HLDQLPRDIA
QERMHHDIVR LLDEYNVVRS PGLHSATLST STLSPPLCSP NDYLSNLKPT PSGKKVRKPS
SGGKGGKDGG KDIRVKKKKA MDGKSNLLDT TAVLSPVESL ESPHGYLSDV ASPPMPSPFQ
QSPPMSLNHL QGNGDSHTGQ ISIGKDMSCM SFDPPRLTHL PVSSPSSQGT TSVGGSRGGQ
CDWLTRMHPG VSQQGSFTQG PPITHNMMGA LHGVSTATLS QIMGYQNLPT SHLGSTVHMM
QQPRSRQLQH QNSNSTTVGQ SLNQSFPNVE LNGADMQPNG GSGRSVPIHT VLPQETPMLG
TQFPTPPSQH SYTGPMDNTP NHQLQVPDHP FLTPSPGSPD QWSSSSPHSN LSDWSEGISS
PPTSIHSQMN LIPDQFK
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