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Database: UniProt
Entry: A0A087XBT5_POEFO
LinkDB: A0A087XBT5_POEFO
Original site: A0A087XBT5_POEFO 
ID   A0A087XBT5_POEFO        Unreviewed;      2055 AA.
AC   A0A087XBT5;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   25-OCT-2017, entry version 18.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000003238, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Ensembl:ENSPFOP00000003238, ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000003238};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000003238}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPFOP00000003238}.
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DR   EMBL; AYCK01025663; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01025664; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPFOT00000003243; ENSPFOP00000003238; ENSPFOG00000002258.
DR   GeneTree; ENSGT00830000128247; -.
DR   OMA; LNQTECR; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0050856; P:regulation of T cell receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0043029; P:T cell homeostasis; IEA:InterPro.
DR   GO; GO:0007601; P:visual perception; IEA:InterPro.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR030157; VDCC_L_a1F.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF184; PTHR10037:SF184; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028760};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     34     53       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     73     92       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    104    121       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    182    205       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    261    282       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    294    316       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    455    473       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    493    516       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    585    604       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    654    676       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    813    831       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    851    871       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    883    909       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    943    962       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1012   1033       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1053   1080       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1132   1152       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1158   1179       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1200   1222       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1281   1299       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1374   1397       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1532   1566       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
SQ   SEQUENCE   2055 AA;  231725 MW;  5C1DCBB6D4CE6E9B CRC64;
     QGSNQVQRAP RALFCLKLNN PIRRAALHIV EWKPFDIFIL LAIFANCVAL GVSKPFPEDD
     SNSTNHDLEQ VEYVFLIIFT IETFLKILAY GLVMHPSSYI RNGWNLLDFV IVIVGLFSVV
     LETMTHKSSG EQATTHHMPG KPGGLDVKAL RAFRVLRPLR LVSGVPSLQI VLNSIMKAMV
     PLLHIALLVL FVIIIYAIIG LELFIGRMHR TCYYIGTDNY VEDEPVPCAF AGHGRQCTVN
     GSECRGRWDG PNGGITNFDN FFFAMLTVFQ CITMEGWTDV LYWMNDAIGF ELPWVYFVSL
     VIFGSFFVLN LVLGVLSGEF SKEREKAKAR GDFQKLREKQ QMEEDLCGYM DWITQAEDMD
     ELDEDGNPRK SDSRPSLGDL SDKKRKFGWF SHSNDTHASL PASETASENT ENIDEEHTNC
     CQTFRLLKGS FCLSRTLRRW NRVCRRNCRT AVKSVTFYWL VLLLVFLNTS LSASEHYNQP
     DWLTQVQDIA NKVLLSLFTV EMLLKMYSLG LAHYFVAFFN RFDCFVVCGG IIETILVELE
     IMPPLGIAVL RCVRLLRIFK VTRHWTALSN LVASLLNSMK SIASLLLLLF LFLIIFALLG
     MQLFGGKFNF DETQTKRSTF DAFPQALLTC FQILTGEDWN VVMYDGIMAY GGPVFPGMIV
     CVYFVILFIC GNYILLNVFL AIAVDNLAGG DGDDKKKKTE GEGEQEAEGE VKSRISASVF
     GPVDFSKLKP KTVLVKDSED LLNEPEPECP SPAGSGDTVG RPSAPDGGVQ LKMADLAPPK
     EKVLPIPDGS AFFCLSKTNP IRVACHTLIH HHIFTNLILV FIILSSCSLA AEDPIRAHSF
     RNNILGYADY AFTSIFTVEI LLKMTVHGAF LHQGSFCRNW FNLLDLLVVS VSLVSFFLHS
     SAISVVKILR VLRVLRPLRA INRAKGLKVT GCEGLAIRTI GNIMIVTTLL QFMFACIGVQ
     LFKGKFYRCT DEAKSTPEQC KGTFVVYKDG DVSHPMVRER IWLNSDFNFD NVLMGMMALF
     TVSTFEGWPA LLYKAIDANG ENSGPIYNYR VEISIFFIVY IIIIAFFMMN IFVGFVIITF
     REQGEQEYKN CELDKNQRQC VEYALKAQPL KLYIPKNPVQ YKFWSIINST GFEYVMFVLI
     LLNTVTLAVQ HYEQSKTFSY VMDILNMVFT GLFTVEMLLK LLALRLRVQN RMQTDNRSHY
     FVDAWNSFDA LIVVGSVVDI VVTEFSVSSR SQCFCFQSGE DSSRVSITFF RLFRVMRLVK
     LLNKGEGIRT LLWTFIKSLQ ALPYVALLIA MIFFIYAVIG MQTFGKIAMQ DYTQINRNNN
     FQTFPQAVLL LFSRCATGEA WQEIMLASLP GKRCDPESDY EPGEEFSCGS NFAIVYFISF
     FMLCAFLIIN LFVAVIMDNF DYLTRDWSIL GPHHLDEFKR IWSEYDPEAK GRIKHLDVVA
     LLRRIQPPLG FGKLCPHRVA CKRLVAMNMP LNADGMVTFN ATLFALVRTA LKIKTEGNPE
     QENEELRAII KKIWKRMKPK LLDEVIPPHS AEEEVTVGKF YATFLIQDYF RKFRKRKEKG
     NVTGESDSTN PSAVQLCKAG LKTLQDLGPE MRLALNEDLE DEEEALMDGE GRKRIWTRDS
     TRLHTDTYCF QRNKPATNMF ESTHLFHKYI ELNLPSLLPS SSSLIKPQIL KIRPTMTFNL
     KKENDQILAI SFSLSMNSRG DGGVSNGGLI HRVGSLSKMA NGNEHDEHLR RGDSVRSSVS
     HLRRASPTEK LTEATQVSPE SKEGSPVAVC RRDSRDRSWR NGDVDVYGEQ GYYSREEDNE
     SITSRDRMDY LSPDCVLRHY PDDLSLYRDH RDGHAPYSNG SYGDSYSEGR RTTRRRLLPA
     TPTAGRKPSF NIQCLRRQGS SDDLPIPGTY HPTSPPRRAR PQAFSSYDSR RSSTRSAVVS
     SASWAKPCPR RGRLLYAPLI LVEEEGSPPW GGEGKNGGAA RGTADGPPWF GGSAGSSAPP
     PYRAYTTLRV PSQLGAPFAE KRGSADSLVE AVLISEGLGL YARDPKFVAF AKREIADACH
     MTVDEMESAA SDLLS
//
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