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Database: UniProt
Entry: A0A087XDR3_POEFO
LinkDB: A0A087XDR3_POEFO
Original site: A0A087XDR3_POEFO 
ID   A0A087XDR3_POEFO        Unreviewed;      1977 AA.
AC   A0A087XDR3;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   31-JAN-2018, entry version 19.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000003916, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Ensembl:ENSPFOP00000003916, ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000003916};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000003916}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPFOP00000003916}.
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DR   EMBL; AYCK01005382; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01005383; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01005384; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPFOT00000003924; ENSPFOP00000003916; ENSPFOG00000003269.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028760};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     45     64       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     84    103       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    115    132       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    190    213       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    269    290       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    302    324       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    445    463       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    483    505       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    575    595       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    652    674       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    771    789       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    809    829       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    887    916       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    971    992       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1012   1039       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1096   1116       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1128   1148       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1238   1256       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1330   1353       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1487   1521       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED     1509   1529       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1977 AA;  221979 MW;  A55A1871B5748CEE CRC64;
     RRRGGGAKKA MQANKSALRA PRALCCLTLS NPIRMAALAL VEWKPFDIFI LLAIFANCVA
     MGVTKPYPDD DSNPTNHQLE QVEYVFLVIF TIETFTKILA YGLVMHPSAY IRSGWNLLDF
     IIVIVGLFSV IAEGMTDHKP GEAHHAAGKP GGLDVKALRA FRVLRPLRLV SGVPSLQIVL
     NSIMKAMVPL LHIGMLVMFV IIIYAIIGLE LFLGRMHKTC FDTSTGLMVE DDPSPCAFAG
     VGRLCVTNGT ECKGKWEGPN GGITNFDNIF FAMLTVFQCI TMEGWTDVLY WMNDAIGFDI
     PWVYFVSLVI FGSFFIINLV LGVLSGEFSK EREKAVARGE LQKAQESKQM EEDMIGYMDW
     LIEAEDVDEE GNKHTLEEKI KKSKFWDQSE CLTESDSDDD IAYLDDDSGF CASLMAKMMA
     NSFCDQLCQL NHTMRKNCRV AVKTTNFYWL VLLLVFLNTV ASASEHYGQP KWLTEMQERA
     NKILLMLFTL EMLMKMYAFG LQIYFMALFN RFDCFVVCGG ILETLLVEMD VIPPIGISVL
     RCIRLLRIFK MTRHWAALSD LVTSLLNSMK AICSLLLLLF LFLIIFALLG MQLFGGKFNF
     DETQMKRSTF DSFPQALLTC FQILTGEDWN AVMYDGIMAY GGPIFPNMVV CIYFVILFVC
     GNYILLNVFL AIAVDNLASG GGKKAVEEKK EEEEDWDEDE EKEDEDNEED DWQENEELRA
     IEGLEGVAPL KPEFSGPKEK IVPIPDGSSF FILGKKNCLR VACHNLIHHP YFTNFILIFI
     ILSSISLAAE DPIKSHSFRN IVLGYADYVF TSVFTVEIVL KMTVYGAFLH TGSFCRNAFN
     LLDLLVVSVS LTSFFLHSSA ISVVKILRVL RVLRPLRAIN RAKGLKNVVQ CVFVAIRTIG
     NILIVTTLLQ FMFACIGVQL FKGRFYSCTD EAKHTPDECK GTFVVYKDGD MNHPMVRERI
     WENSDFNFDN VLMGMLALFT VSTFEGWPQL LYRAVDANAI NRGPIYNYRV EISIFFIIYI
     IIIAFFMMNI FVGFVIITFR EQGEAEFKNC ELNKNQFRPT QRQCVYYALK AQPIKIYIPK
     NPSQLKFWRI INSSQFEYVM FVLILGNTLT LGVQHYEQSK LFTSIMDILN MIFTVVFTIE
     MIIKLMALRA HHYFIDPWNS FDALIVVGSV LDIAVSEFSF FLPLNFPSIQ SQGGGKGESG
     KVSITFFRLF RVLRLVKLLS KGEGIRTLLW TFVKSLQALP YVGLLIAMIF FIYAVIGMQM
     FGKVAIDDDT DINRNCNFQT FFMAVLVLFR CATGEQWQQI MLGALPGRRC DPEADVEPGE
     EYTCGSNLAY LYFISFFMLC AYLIINLFIA VIMDNFEYLT RDWTVLGTHH LDEFKRVWSD
     YDPEATGRIK HIDVVTMLRR IQPPLGFGKL CPHRVACKRL VAMNVPLHPD GTVTFNATLF
     ALVRTSLKIK TEGPVDQQNE ELKIIIKKLW KHTKPKLIDE IIPPPRGDEV TCGKFYASFL
     IQDYFKKYRK RKERERKSKR KDKAAALQQG LRTLQDLAPE MRLAMACDLE EEEATEGEMT
     GDEIFDSEPG TSANPTPAST PMPPLDLLVE HTAVIMEPTP RGAGGEVITT QNYHMPYFPS
     FPLHSCRFEY QEAISPVPTE TGDNGQSLDV ASSIGEIPYE GHDPNGFISK AYNENNMNGG
     SAAVSPAPYD ANEYNSNGYT GYNRNESTMS GYNDNGSTVS CYNGSTGYNG NTGYNGNGYN
     GNGYNGNENS GAHFVRRRLL PAIPKASGRK PAFNFQCLKP QSSADDLPVP GSYRGNTSPS
     RSRLQNQQSL DSRPSSVSSM SSASWANAAA AGATPLPGII APTARRGKLI YTPMILVDEP
     LWCDGSASLP AGKRPGWYPG QTRTFTSVRM PPAANQSIID KGSADSLVES ILISEGLGMY
     ARDPKFVSFA KREIAEACHM SLDEMESAAA DLIARGASHL TRFEDELADE MNCVISY
//
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