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Database: UniProt
Entry: A0A087XFM2_POEFO
LinkDB: A0A087XFM2_POEFO
Original site: A0A087XFM2_POEFO 
ID   A0A087XFM2_POEFO        Unreviewed;      1703 AA.
AC   A0A087XFM2;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 2.
DT   25-OCT-2017, entry version 24.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000004575, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Ensembl:ENSPFOP00000004575, ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000004575};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000004575}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPFOP00000004575}.
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DR   EMBL; AYCK01019752; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01019753; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01019754; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01019755; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01019756; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01019757; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01019758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01019759; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01019760; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01019761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPFOT00000004583; ENSPFOP00000004575; ENSPFOG00000003470.
DR   GeneTree; ENSGT00830000128242; -.
DR   OMA; TMLLPRP; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0019233; P:sensory perception of pain; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR028809; Na_channel_a10su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   PANTHER; PTHR10037:SF208; PTHR10037:SF208; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF00612; IQ; 1.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028760};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     16     34       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     55     82       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    393    411       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    423    446       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    503    531       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    591    616       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    878    896       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    917    935       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    994   1020       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1117   1140       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1199   1217       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1229   1247       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1254   1279       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1316   1344       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1420   1443       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN        7     88       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      393    621       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      630    872       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      876   1149       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1198   1453       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1457   1520       GPHH. {ECO:0000259|Pfam:PF16905}.
FT   COILED       90    117       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1703 AA;  192858 MW;  D757B976752C1AAE CRC64;
     CPDGFDCLKT GRNPNYGYTS FDTFGWAFLS LFRLMTQDYW ENLYHHTLRS AGKTYMVFFV
     VVIFLGSFYL INLILAVVAM AYEEQNQATI AEACQKEREF QQAMERLKKE QQMAAQKPPD
     SDSLTSPDLS PLGPPLDSSE ERRRSQALMG VADGEGNLSE EKLLQVDLMD GGKALHPLLA
     RSFSTRTRRS SQVSSIFNFR LRSRGSEGEM ADDEFSVPGD VVDSVGGRTY SGGTFSGILT
     NPWPKRRLST YSTASRNSQF DGFGSSGSDA ESVSSSGGSV PYQRNQPESK PAGGGLCSAE
     SHETQPDTEV PTSTTELSTM LLPRPSSTQG SERRGRAMSA ASYLTDVMEE LEESHKKCHP
     CWYVFAHRYL VWECSPSWLR LKQLVKIMVM DPFLDLAITV CIVLNTLFMA MEHYPMTPEF
     NGMLSIGNLV FSGIFTAEMV LKIIALDPYY YFQTGWNIFD SIIVCLSLME LGLSDVEGLS
     VLRSFRLLRV FKLARSWPTL NTLIKIIGNS MGALGNLTLV LAIIVFIFAV VGMQLFGKNY
     QECVCKISKD CVLPRWHMKD FFHSFLIVFR VLCGEWIETM WDCMEVAGQP LCILVFMLVM
     VIGNLVLLNL FLALLLSSFS SDNLSAPDED GEMNNLQIAI HRITLGLGWC RRQVVDFFNG
     NLKRRRQKRK EAKAMMKLKR LSTVHTEANG AVIGRHVEKY VVPEDDSYMT NPNLTISVPI
     APGESDVEFL WTEEEKEIRF YRSKQNLSRP LSVKFGPDPP CFCTWKDQQV SAGAGPGKRQ
     TVQISLLRPQ QKLIPPSSLC GQKEEVSLSE GSTVDLRKPG EEEDEYSELA EEAMDPDNCF
     PDVCVSRFQC CDIDTTAGLG QMWWRTRKTC YQIVEHSWFE SFIIFMILLS SGALAFEDIY
     IEQRRVVKVV LEYADKIFTY IFILEMMLKW LAYGFKKYFT NYWCWLDFLI VDVSLVSLVA
     NTLGYSDLAA IKSLRTLRAL RPLRALSRFE GMRVVVNALI GAIPSIMNVL LVCLIFWLIF
     SIMGVNLFAG KFGRCVNRTG FVYDASIINN RSECNAANDT SQHYWTKVKV NFDNVGAGYL
     ALLQVATFKG WMDIMYAAVD SRATDEQPIK EINLYMYLYF VIFIIFGSFF TLNLFIGVII
     DNFNQQKRKL GGQDIFMTEE QKKYYNAMKK LGSKKPQKPI PRPLNDLQGF FFDLVGKQAF
     DIIIMVLILL NMITMMVETD EQSPQMEKIL YYVNLAFIVI FTTECSIKIM ALRCYFFTVG
     WNIFDFVVVI LSIVGIVLAD IIEKYFVSPT LFRVIRLARI GRILRLIRGA KGIRTLLFAL
     MMSLPALFNI GLLLFLVMFI YAIFGMANFA YVKRQGGIDD MFNFETFGNS MLCLFQITTS
     AGWDSLLSPI LNNSPEECDP HLPHTGTTVK GNCGNPSVGI TFFVTYIIIS FLIVVNMYIA
     IILENFSVAT EESTEPLSED DFEMFYEVWE KFDPEATQFI EYSKLSDFAD SLLEPLRIGK
     PNKIKLISMD LPMVSGDKIH CLDILFAFTK RVLGESGEMD ALKQQMEEKF MISNPSKISY
     EPITTTLRRK QEEVSATIIQ RCYRRHLVRR QMKAASYMYR QFTTPRHDHS EGEEGGEVMF
     GEDAPEKEGL IATMMKENYG SSLLGVERSS TMSSTSSPPS YNSVTRATSE NLQPLAAKTE
     TADDGDVREQ SQAEADRETE TEP
//
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