ID A0A087XFX8_POEFO Unreviewed; 489 AA.
AC A0A087XFX8;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=Karyopherin alpha 2 (RAG cohort 1, importin alpha 1) {ECO:0000313|Ensembl:ENSPFOP00000004681.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000004681.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000004681.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the importin alpha family.
CC {ECO:0000256|ARBA:ARBA00010394}.
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DR EMBL; AYCK01008239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01008240; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A087XFX8; -.
DR STRING; 48698.ENSPFOP00000004681; -.
DR Ensembl; ENSPFOT00000004690.2; ENSPFOP00000004681.2; ENSPFOG00000004947.2.
DR eggNOG; KOG0166; Eukaryota.
DR GeneTree; ENSGT01050000244891; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR PANTHER; PTHR23316:SF12; IMPORTIN SUBUNIT ALPHA-1; 1.
DR Pfam; PF00514; Arm; 5.
DR Pfam; PF01749; IBB; 1.
DR SMART; SM00185; ARM; 7.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 4.
DR PROSITE; PS51214; IBB; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Transport {ECO:0000256|PROSITE-ProRule:PRU00561}.
FT DOMAIN 27..93
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT REPEAT 153..196
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 196..224
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 285..327
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 327..369
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
SQ SEQUENCE 489 AA; 54166 MW; 90CB13DCEAA082C8 CRC64;
MHEVLLFKRN NKRHKTVCTG ITPLQDLFSA LPNHTHTHKM SENVARLNKF KNKGRDANEL
RRRRVEVNVE LRKAKKDDQM FKRRNVAAAP DEATSPLQER NQNCQAFRQW TVEEIVAGVN
SGSLESQLQA TQAARKLLSR DKHPPIDQMI ASGLIPKFVS FLALTDCPPI QFEASWALTN
IASGTSAQTM AVVDGGAIPA FISLVTSPQQ HISEQAVWAL GNIAGDGSAL RDKVLKHGAV
APLLTLLAVP HLTVFTPGYL RNVTWTLSNL CRNKNPSPPV HAIQQILPAL IRLLHQDDLE
VLADACWAVS YLTDGSNDRI EMVVETGVIP RLVKLLGFQE LAVVTPALRA LGNIVTGTDE
QTQAVLDASA LSMFPNLLRH KKANIQKEAA WTLSNITAGK DTQIQEVINA GLVPYMVDML
VRVRSGHSYR GSTKTNKLKL KTFWIKTVIT RGGKLTTNYR TLCVYLKPTE ILDASLIFVF
MNLFTSLLK
//