ID A0A087XGP4_POEFO Unreviewed; 285 AA.
AC A0A087XGP4;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=CD74 molecule {ECO:0000313|Ensembl:ENSPFOP00000004947.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000004947.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000004947.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR EMBL; AYCK01002990; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007548367.1; XM_007548305.2.
DR AlphaFoldDB; A0A087XGP4; -.
DR STRING; 48698.ENSPFOP00000004947; -.
DR Ensembl; ENSPFOT00000004956.2; ENSPFOP00000004947.1; ENSPFOG00000004979.2.
DR GeneID; 103135523; -.
DR KEGG; pfor:103135523; -.
DR CTD; 58113; -.
DR eggNOG; KOG1214; Eukaryota.
DR GeneTree; ENSGT00390000008961; -.
DR OMA; HHNCSEP; -.
DR OrthoDB; 2972165at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035718; F:macrophage migration inhibitory factor binding; IEA:InterPro.
DR GO; GO:0042289; F:MHC class II protein binding; IEA:InterPro.
DR GO; GO:0019882; P:antigen processing and presentation; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0070206; P:protein trimerization; IEA:InterPro.
DR CDD; cd00191; TY; 1.
DR Gene3D; 1.10.870.10; MHC class II-associated invariant chain, trimerisation domain; 1.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR InterPro; IPR043530; CD74_antigen.
DR InterPro; IPR015386; MHC_II-assoc_invar/CLIP_MHC-bd.
DR InterPro; IPR022339; MHC_II-assoc_invar_chain.
DR InterPro; IPR011988; MHC_II-assoc_invariant_trimer.
DR InterPro; IPR036613; MHCII_invariant_trimer_sf.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR14093; HLA CLASS II GAMMA CHAIN; 1.
DR PANTHER; PTHR14093:SF17; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN; 1.
DR Pfam; PF09307; MHC2-interact; 1.
DR Pfam; PF08831; MHCassoc_trimer; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR PIRSF; PIRSF001992; CD74_antigen; 1.
DR PRINTS; PR01990; CD74ANTIGEN.
DR SMART; SM00211; TY; 1.
DR SUPFAM; SSF48305; Class II MHC-associated invariant chain ectoplasmic trimerization domain; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR001992-1}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 39..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 197..257
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 200..218
FT /evidence="ECO:0000256|PIRSR:PIRSR001992-1"
FT DISULFID 229..236
FT /evidence="ECO:0000256|PIRSR:PIRSR001992-1,
FT ECO:0000256|PROSITE-ProRule:PRU00500"
FT DISULFID 238..257
FT /evidence="ECO:0000256|PIRSR:PIRSR001992-1"
SQ SEQUENCE 285 AA; 31687 MW; 81F121F6CE703ED9 CRC64;
MADNQEDAPL ARGSVSGSHE VLVNNAGPRG GSNSRALKIA GLTTLACLLL ASQVFTAYMV
FDQKQQIHTL KKSSERMSKQ VTRVSQGGVA PARMAMPMNS LPLLADFTED DTSSKTPLTK
VEDIAIVSVE KQVMDMMKDV SLPQFNETFL ANLRSLQQQI NESEWKNFES WMRYWLIFQM
AQQKPAGPTP QPASLIKTKC QMEATPGVGK IGAYKPQCDE QGHYKPMQCW HATGFCWCVD
QSGNPIQGTT MRGRPDCNRG AGFRRMMVAP RMMQKTFLEE EGKVN
//
