ID A0A087XI60_POEFO Unreviewed; 439 AA.
AC A0A087XI60;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 24-JAN-2024, entry version 44.
DE SubName: Full=Neutrophil cytosolic factor 1 {ECO:0000313|Ensembl:ENSPFOP00000005463.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000005463.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000005463.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AYCK01023771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A087XI60; -.
DR STRING; 48698.ENSPFOP00000005463; -.
DR Ensembl; ENSPFOT00000005472.1; ENSPFOP00000005463.2; ENSPFOG00000005500.1.
DR eggNOG; KOG4773; Eukaryota.
DR GeneTree; ENSGT00940000160014; -.
DR OMA; TEYCNTL; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0016176; F:superoxide-generating NADPH oxidase activator activity; IEA:InterPro.
DR CDD; cd12022; SH3_p47phox_2; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR015039; NCF1_C.
DR InterPro; IPR032136; NCF1_PBR/AIR.
DR InterPro; IPR035757; NCF1_SH3_2.
DR InterPro; IPR001655; P47PHOX.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15706:SF6; NEUTROPHIL CYTOSOL FACTOR 1-RELATED; 1.
DR PANTHER; PTHR15706; SH3 MULTIPLE DOMAIN; 1.
DR Pfam; PF16621; NCF1_PBR_AIR; 1.
DR Pfam; PF08944; p47_phox_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00498; P47PHOX.
DR SMART; SM00312; PX; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 32..153
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT DOMAIN 185..244
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 255..314
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 306..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..326
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..359
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..404
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 439 AA; 50966 MW; E8D4F5D5A8D38105 CRC64;
MISCGVTTHR LFKQSSCNSF DFSFQPYSME EIYVRHVELL GFEKRFFPSQ HYVYRLMVKW
SDESEKLIYR TYPEIHTFHK SLKEMFPIEA GQIDKRDRVI PSLPAPRWVE SQKSREIRKI
TLAEYCESLI NLPAHISRCK HLSSFFKVRP EDENPPAPNT MKRNDLFAES RELARATASE
ISGPIILDTY RVIADFEKTS KHELNLYTGD FVEIVEKNQN GWWFCQCESK RGWVPASYLE
PLDGPEEAEE PEPDYEGELH VVIQAYQGEQ EDEISLEVGD TVEVIHKLLD GWWVIRKGEE
TGHYPSMFLQ KSDKKNETDR TNLRGQRPPP RRSTIRNAKS IHSKSRQKLS QDAYRRNSRR
YLQQKGVTPP KRNSGKVPLK ERKNEDNIPE VSESSSESEL KKEAPVIPPR PSPELILERC
TDNTRKKMSV HKSGSGSSC
//
