ID A0A087XJE2_POEFO Unreviewed; 586 AA.
AC A0A087XJE2;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Regulator of G protein signaling 14 {ECO:0000313|Ensembl:ENSPFOP00000005895.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000005895.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000005895.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AYCK01002992; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007548374.1; XM_007548312.2.
DR AlphaFoldDB; A0A087XJE2; -.
DR STRING; 48698.ENSPFOP00000005895; -.
DR Ensembl; ENSPFOT00000005904.2; ENSPFOP00000005895.2; ENSPFOG00000005903.2.
DR GeneID; 103135528; -.
DR CTD; 100003648; -.
DR eggNOG; KOG3589; Eukaryota.
DR GeneTree; ENSGT00940000166254; -.
DR OMA; MAKNCNA; -.
DR OrthoDB; 22856at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd17139; RBD2_RGS14; 1.
DR Gene3D; 1.10.196.10; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003109; GoLoco_motif.
DR InterPro; IPR046993; RBD2_RGS14.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR046995; RGS10/12/14-like.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45945:SF2; REGULATOR OF G-PROTEIN SIGNALING 14; 1.
DR PANTHER; PTHR45945; REGULATOR OF G-PROTEIN SIGNALING LOCO; 1.
DR Pfam; PF02196; RBD; 1.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00390; GoLoco; 1.
DR SMART; SM00455; RBD; 2.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50877; GOLOCO; 1.
DR PROSITE; PS50898; RBD; 2.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760}.
FT DOMAIN 58..175
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 295..365
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT DOMAIN 367..437
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT REGION 194..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..474
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 572..586
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 586 AA; 63440 MW; 8550E4EFFC0B9DCB CRC64;
MAKNCNSLGI PLAHMSQAVS DGELNMTARG CGGSSSSLPG TPGGDVNSAN SVLSWAVSFE
KLLEDPHGVS YFTAFLKSEV SAENILFWQE CEKFRKIPAT SLDRLKAAAR SIYDTYLSDC
APYSVNIDDT AKTEEKDLEQ PTPDMFSKAQ AQIFKLMKMD SYRRFVRSPL YQRCTLASVE
GKFLPQLSTE PVRMGSWDDM ANKSPSSDKK NRKSDSNSLP SGKSVSEKQR QKRGSWGDAS
NGQGSGPLKQ SNMSIKSTSS VELGSLCRQM ENGWPGPTSR DQAAGIVSRM GMEGGYCCVY
LPDGSASLAP TRNGQPIKDM LASLCEKRGF PLKDVMIYLH GKDKPLSLDQ DCSVLRDQQV
SLELRVTFAL ENAFTGKTVG IMAKSSKTLQ DALCSVMQKH NLKPQETVVT MVGSDVPVNL
NCSVYKLANK TLRLEKAKGK DQAIISRGGS SPNAQPGAGS GGLEPQLSTQ TDRVRTQHRP
SKNRDMDGFL DMLTRAQCCR VDDQRGLLTK EQLEIPSFLQ LSSDQGQNTD DSSATSSSTT
DSKPESGDNS DAPDPAPVPD PAPANKSEES SAAPKSESKD LRETTV
//
