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Database: UniProt
Entry: A0A087XLG9_POEFO
LinkDB: A0A087XLG9_POEFO
Original site: A0A087XLG9_POEFO 
ID   A0A087XLG9_POEFO        Unreviewed;      3549 AA.
AC   A0A087XLG9;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 2.
DT   25-OCT-2017, entry version 23.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSPFOP00000006622};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSPFOP00000006622};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000006622, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Ensembl:ENSPFOP00000006622, ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000006622};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000006622}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPFOP00000006622}.
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DR   EMBL; AYCK01021522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01021523; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01021524; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01021525; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPFOT00000006634; ENSPFOP00000006622; ENSPFOG00000005820.
DR   GeneTree; ENSGT00760000119152; -.
DR   OMA; EHMPNDT; -.
DR   OrthoDB; EOG091G00T0; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 1.
DR   Pfam; PF02026; RyR; 2.
DR   Pfam; PF00622; SPRY; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028760};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2851   2874       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3084   3103       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3153   3175       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3350   3371       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3426   3449       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1    143       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     2606   2632       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   3549 AA;  405169 MW;  6CE4B446DA78202B CRC64;
     PSLPVQYYYS VRIFPGQEPS SVWVGWVTSD FHQYDPSFEL NKVRTVTVTL GDEKGKVHES
     IKRSNCYMVW AGESSSPGQG RNNNGLEIGC LVDTTNGLLS FTANGKELSM YYQVEPSTKL
     FPAVFAKATS PNVFQFELGR IKNVMPLSAG LFKSERKNPA PQCPPRLHVQ FLTPVLWSRV
     PNHFLKVSAS RVNDRHGWQV QCSDPLQFMS LHIPEENRSV DILELSEQKG LLKFHYHTLR
     LYSAICALGN NRVAHALCSH IDEAQLLQAI ENKYMPGLLR AGYYDLLIDI HLRSYATARL
     MMNNEYIVPM THETKSITLF PDDLKKHGLP GIGLSTSLRP RMHFSCPSFI RVTESSCHDN
     YSPEFPLDIL KVKTIEMLTE AVLEGSMHVR DPVGGSTELL FVPLIKLVYT MLIMGIFQNG
     DLKNILQLIE PSVFSEPRDG QEELPRELEM LKNVETTGRG ENGGRNLPKE GLLQMKLPEP
     VKLQMCHVLQ YLCDCQVRHR IEAVVAFSDD FVACLQDNQR FRYNEVMLAL NMSAALTAKK
     TKEFRSPPQE QINMLLNFKD DKQECPCPEY IREQLLDFHE DLMRHCELDE ERGIDGDSDF
     TIRGRLMSLV EKVSYLKKKM GSLPKEKKDR KPSTLQQLIS DTMVRWAQES VIEDPELVRA
     MFVLLHRQYD GIGGQVRALP KAYTINSVSI EDTINLLAAL GQIRSLLSVR MGREEEKLMI
     RGLGDIMNNK VFYQHPNLMR ALGMHETVME VMVNVLSGGD SKEITFPKMV ANCCRFLCYF
     CRISRQNQKA MFDHLSYLLE NSSVGLVISL MRGSTPLDVA AASVMDNNEL ALALREPELE
     KVVQYLAGCG LQSCVMLVHK GYPDIGWNPV EGERYLDFLR FAVFCNGESV EENANVVVRL
     LIRRPECFGP ALRGEGGDGL LAAMEEAIRI SQDPSRDGPS PVSESSRTLS DMLDEEEDDT
     IHMGNAIMTF YSALIDLLGR CAPEMHLIHA GKGEALRIRA ILRSLIPIED LVGVISIPFS
     MPNLAKDGTV VEPDMSAGFC PDHKAAMVLF LDRVYGIEDQ NFLLHLLEVG FLPDLRAAAS
     LDTAALSATD MALALNRYLC TAVLPLLTKC APLFAGTEPF ASLIDSLLHT VYRLSKGCCL
     TKAQRDAIEE CLLAVCGKLR PSMMQHLLRR LVFDVPLLNE HTKMPLKLLT NHYERCWKYY
     CLSGGWGSFG VASDEELHLS RKLFWGIFDA LSCKRYDQEL FKLALPCLSA VAGALPPDYM
     ESNYMALMEK QSSMDSEGNF NPQPADTTNV TVPEKLDYFI TRYAEHNHER WCIEKFSHGW
     TYEEHLCESS KTHPLLKPYK ALSEKDKEAY CWSVRESLKT MLSWGWSIDR SREGDTATLH
     NKSRRISQAS QQNNVPHPRP VDMSNVTLSR DMQSMAELLA ENYHNIWARQ KKMELEAKGG
     GRHPLLVPYD TLTAKEKSKD REKAQDILKF LQINGYIVSR GKKSPELDTP AIEKRFAYTF
     LQKLITYVDQ AHQHMMEFVS DVGAKLKGGK IPHEQQIKFF GKVVLPLVDQ YFKNHRLYFL
     STAIHPISSG GHASNKEKEM VTSLFCKLGV LVRHRISLFG NNATSIVNCL QILGQSLDAR
     TVMKTGLESV KAALWSYFDS VAEDLEKTQE NLKLGQFTHS REQPRGVTQI INYTTFALLP
     VLSSLFEHIG QNMFGEDLML DEVQVSCYRI LNSLYFLGTN KSIYVERQRP ALGKCLAAFS
     AAFPVAFLEP QLNKFNGFSI YNKASKDRTA LGLPGPVGEV CPLVPNLEKS LEEIMELAES
     GMKYTQMPHV MEVVLPMLCS YMSHWWEHGP ESNPDKDDSC CTSVTSEHMN TLLGNILKII
     YNNLGIDEGA WMKRLAVFSQ PIISKAKAQL LQTHFLPLMD KLKKKAAVVL TDEEQSRAEG
     RGEMSETELL IMDQFTILVR DLYAFYPLLI RFVDYNRGRW LKESNPEAEE LFRMVAEVFI
     FWAKSHNFKR EEQNFVVQNE INNMSFLISD TKCKMSKLIG LQGIVSDQER KKMKRKGDRY
     STQTSLIVAT LKRLLPVGLN ICAPGEQELI ALAKNRFTQK DTEDEVREII RNNLHLQGKL
     EDPAIRWQMA LYRDLPYHYE DASDPEKTVK RVLDIAHVLF HLDQVEHPQR SKKAVWHKLL
     SKQRKRAVVA CFRMAPLYNL PRHRAVNLFL QGYEKSWIEA EEHYFEDKLI EDLAKAGERE
     PSEEEEGIKH IDPLHQLIQL FSRTALTEKC KLDEDNLYMA YADIMAKSCH DEEDEEGEVK
     SFEEKEMEKQ KLLYQQARLH DRGAAEMVLQ TISASKGVMG PMVASTLKLG IAILNGGNST
     VQQKMLDYLK DKKDVGFFQS LAGLMQSCSV LDLNAFERQN KAEGLGMVTE EGSVITHERG
     EKVMQDDEFT CDLFRFLQLL CEGHNSDFQN YLRTQTGNNT TVNIIISTVD YLLRVQESIS
     DFYWYYSGKD VIDEQGQRNF SKAINVAKQV FNTLTEYIQG PCTGNQQSLA HSRLWDAVVG
     FLHVFAHMQM KLSQDSSQIE LLKELMDLQK DMVVMLLSML EGNVVNGTIG KQMVDMLVES
     SNNVEMILKF FDMFLKLKDL TSSDGFKEYD PDGKGVISKR DFHKAMESHK HYTQSETDFL
     LSCAETDENE LLDYEEFVMR FHEPAKDIGF NVAVLLTNLS EHMPHDTRLQ TFLELAESVL
     NYFQPYLGRI EIMGSAKRIE RVYFEISESS RTQWEKPQVK ESKRQFIFDV VNEGGEKEKM
     ELFVNFCEDT IFEMQLAAQM SDAGERSAVK EESEREKCDE ENPDMGFFSM STVRLALIAL
     RYNVMLLIKV LSMKSLKKQM KKIKNMTLKD LVTTLVSFYW SVLLGLLHVT FSVARGFCRI
     FYNTFMGGNL VEGAKAVKVS ELLATMPDPT QDEVRGEGDE REKRLSERSS PKEDLADLAV
     NTSETELLSD IFGLDLRREG GQYKITPHNP NATLTELLNS PVPPSAPPPA PQPELRQRHQ
     SKSGSSEKKE EIPEAEVEPE KIEEHVVKQE KQVKNEKMKS KVRKHHNSKS DEPDLQESAV
     LKKILAYQRK LLNYFARNFY NMRMLALLVA FAINFILLFY KVMGNWVCSV QWDPLLGERL
     ESNERVSDET GEPLKPVSVR FVLEESSGYM EPMLRILAVL HTVISFFCII GYYCLKVPLV
     IFKREKEVAR KLEFDGLYIT EQPSEDDIKG QWDRLVINTQ SFPNNYWDKF VKRKVMDKYG
     EFYGHDRISE LLGLDKAALD FSDAHKKRKP RKDSSLAAVL NSIDVKYQIW KLGVVFTDNS
     FLYLAWYMTM SILGHYNNFF FAAHLLDIAM GFKTLRTILS SVTHNGKQLV LTVGLLAVVV
     YLYTVVAFNF FRKFYNKSED GELPDMKCDD MLTCYMFHMY VGVRAGGGIG DQIEDPAGDE
     YEIYRIIFDI TFFFFVIVIL LAIIQGLIID AFGELRDQQE QVKEDMETKC FICGIGNEYF
     DTVPHGFETH TLQEHNLANY LFFLMYLINK DETEHTGQES YVWKMYQERC WEFFPAGDCF
     RKQYEDQLN
//
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