ID A0A087XM87_POEFO Unreviewed; 4847 AA.
AC A0A087XM87;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=E3 ubiquitin-protein ligase HERC1 {ECO:0008006|Google:ProtNLM};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000006890.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000006890.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AYCK01007580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 48698.ENSPFOP00000006890; -.
DR Ensembl; ENSPFOT00000006902.1; ENSPFOP00000006890.1; ENSPFOG00000006327.1.
DR eggNOG; KOG1426; Eukaryota.
DR GeneTree; ENSGT00940000166813; -.
DR OMA; QWDESAE; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR CDD; cd12881; SPRY_HERC1; 1.
DR CDD; cd14401; UBA_HERC1; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035768; SPRY_HERC1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22872; BTK-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR22872:SF6; E3 UBIQUITIN-PROTEIN LIGASE HERC1-RELATED; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00415; RCC1; 12.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00400; WD40; 2.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00449; SPRY; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 3.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS00626; RCC1_2; 4.
DR PROSITE; PS50012; RCC1_3; 14.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT REPEAT 383..432
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 433..487
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 488..540
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 541..590
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 592..643
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 644..694
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 695..747
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 1988..2177
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REPEAT 3404..3445
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 3730..3771
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 3980..4028
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4029..4083
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4084..4135
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4136..4187
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4189..4240
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4241..4292
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4293..4344
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 4484..4834
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1122..1143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1329..1370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1426..1453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2244..2269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2437..2467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2712..2731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2785..2827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2867..2891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1125..1143
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1329..1357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1426..1446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2811..2827
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 4797
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 4847 AA; 532266 MW; 9B399669CF9C26E5 CRC64;
MVPCQTHVLL KWQEHFNSSW AAEDSVQTAR RHGAAGLYNK LLYNKEVVTL AQPVQELASP
RLPDFECESN TSAEKDEYLS SLLHSQRWLA HRMLTQTSYT LGLHQRLVVL QRIYYALHSK
YHDKFRLQLP SQSTDSGAES GPIELASEPR LPGGVSKIKS GTDVLIEMGV RTGLSLLFSL
LQQNWRYAAS VHPESVLCND VLATASSVLA SLPPLSLANE SKIPSVGLDC LGQVADFLKK
TSVSNGSSGA DPTGRRLALE LLLGLGMQRG SLKFLLEWVE VALAASMPSS TAALSSSSSS
LSFQQSPGVG FELIQQTLLQ MRQYSGFRGD PINTQVLTKD ADGLCRLSQA ALYLFEEICN
LASNCLCSCS TDTAAPGAES DAVMVYVWGS NSSHQLAEGT LEKILLPKVT QGFSDAQMIE
AGQYCTFSVS ADGSVKACGK GSYGRLGLGD SNNQSMPKKL VLEPHRNMKK VSSSKGSDGH
TLAITVEGEV FSWGDGEYGK LGHGNSATQK YPKIIQGPLS GKVVVCVSAG YRHSAAVTND
GELYTWGEGD FGRLGHSDSQ SRNMPTLVKD ISGVGQVTCG SSHTIAVAQD GRTVWSFGGG
DNGKLGHGDT NRVYRPKVIE ALHGFIIRKV CAGSQSSLAL TSAGQVFAWG CGSCLGCGSS
ETTSLRPRFI EDLGITKIID ISCGDSHCLA LSHENEVYAW GNNTMGQCGQ GHTSTPITKP
RKVLGLEGIS IQQITAGTSH SLAWTAVPSD RQLVAWHRPF CVDLEESTFT YLRNFLEMYC
DGIGNDTPPA PFVSKRDHHH FLLLCMKLLS IHLSLAHAGG TGAMVLGAQG RPLRNLLFRL
IDTNIPESIQ QAVLNTLSIG ASLLLPPLRE RTELLLSLLP QGPQSLNILS KGQRLQLDMV
LSSLQDQSHV ASLLGYSNFG EVTGLGPPLT PAASGRPPSS SSSVDAYDPL HLAEVLLRTL
LLSIGFYTEQ QFGELEKNSD KQLCGGGEGQ NDPPSQFHQL LSGLHKHLLA HCYIQYSPED
DGSVTLLREH LYLLLPCATE TLKRSTKLLK KSSHDKQIIK KLHIVLYHSV AGSLLCQMMY
SLLLLPLDTV QPLLNHLMSL LEHLNDLNSL LPETSLLEDQ ELGVEAQKAS SEKSEESPNL
GKEQQEEECR WVWILDLERS VALAVGRCLG GMVQGPPPSL HEKMSETWLS NVLLRNGLEM
DFEQLDSTMA WLTEVVLLGN SDARQMELNL TEDSRTLLEL ALGSTRGLAG VMWWKMEEYA
LSKEWEDGGS SEDYLLPIVC RCSLAALLKH TGLQNEACWQ DSRHEPSEML FEVYETVFKL
RSSLLALKNA PKMSQRQDST KQYNSQSPQS PDADSEEPSM SMEQVGKDHE HQPVGYCNRE
VQVPPTPTAN HNHEELTSAE VLESFMATRE AMQVQQNVTV YESFGTSTLP SSMESPVSPE
TQPDPKQQWE NRCESDEGLS FPAACQLVIS RCLFLLLGVR PAWIEPSEEE DNQAVNTVAS
NASWISKRLH HPFLLQEVIA RVFHCVSSWE KAGKLSAERI DVVESYKYII QSPNLKHLHC
FFNSKTNKHR GLPLCSLGIM KEAWDRLRQC ISPGGSMSRS SDNTLPILHQ VFHFTCGGLT
LPPSSPTFPG IQSCGQADPK SITLAIMHQQ QRAEMRLEAL CQMSAFLSKM EEKNTRSSVS
LHFPALLQSV QLQFLSGCFA LGTQIIGSHS GANYETQHYM CGTNAASVET KRALKSAAHT
FYQQVVHVLR LRVQLEKAHP GSSQHLLLAT MFALNFCYQP VDLVLIIKCG ILEILSMLTN
NSCALMNQGW LAASTSGSML LSGAVKLACA RLLQILTVAA SSCEDSLPLE VSHALTEVMC
EQLLNILQNL HQQQTAERLA ADLDSNSRST KLESSKVTES QLADLLVFLR VMERLSTFVK
WIEPLMAIIS PKCPSGSLCF QNFRTKLLAF HVLERLLPAC SDPVQIQQIV EQLFQLLSVY
MWEEPHAEQS YEETIEKETA VFLLQSPGNL DECIPIGDFS FDPDKIVCCS LESGNILSHG
SVGKGYGLAT TGITSGCFIW KFYITKENRG NEGTCIGVSR WPVRDHNHHT TTDMWLYRAY
SGNLYHGGEL VRTLPSFTQG DTITCILDME AHTISFAKND KEPKLAFEGV VASELYPCVL
FYSSNPGEKV ALRDLQMRGM PSNLLPGEPL CSPRTTVLLE STVHLLRRLH QCDHWSSLIN
QYIHSHLELI GVILREDDFK GLDQKSLQGV GPPQTEMEDK DVSGEETGKP AAHRHILSEA
KLTALCVEVW PALAVIGGVD SGLRAGGLCL HKPSGRRAIM LGVLKKGSSL AKLQWEETDL
SVSSMTSWSP SDTPIISLEP CDVSCCDVSR LGGVKPAVLL DLIYLMRLLE EEGWQGPYLP
PRRKYSEEVL KEEEKRGSLD EDFSDGGRWL TEHERKKLKE QNAETDPPPA KPADPEESPG
SAQPIPTSQT LKMDAFALEM RAVRVSYLLI GGLKCLTVFF TCEKLSDLLL VSKQEPPNSP
VIPQHSPVPD QAKAKSKQWD EHAELRSVLQ YVVQSMVKWA VRPCPIKQTV SLADLERAQV
MIYKGALSRL QEDKERKESG RHLSSQSISK SSSSVSLYSA GSEGTAIFGQ SNRVSASSSS
NDLASSLPTN LQADGLESFN PFLPISLLQH VLLTRFPTLT GLDSAPPLLS PCFSFASPAA
CDAFTEQQTS FMEPGPCSTQ ARSSLVSPQS PERTQMFVTS RLLEMGFTMR HIYWAMEAAD
VAGDLDSQTI EVLASWMLEH PLTDNQQAAE SPRLEAVAET PSPDGPETVQ CPERPTNQTS
ERQHGSSSTT VWSSHLYMLA SYWCFVSSLL PGLDWIEREN FLDVHLTRNR PPPARRRRSG
PTQRTSFRRP AVGDWPEHVE FHPFSTEEES ELSYMDDPYH EEAYEDLLTP SFFSLERETS
DVLKLPSHQA GEEHSQMVKC ELCNTFTLQF NNHIKRRHPG CGQSAARKGY DSTGAYVDVW
FKGECGSNFP FYLLCSSCRE KYLTANASDP NSKYERTKGL TSDLIGQLDN TSDDEWEMSH
QVEDDPDKLT GLEDFGLLLR PLGLTEKKLV PDPIVFTEPD PLGALVYSSS SPTRVASKAL
SLRVACKLTV AVDQKTSLSL GQQAVSLRDS HDRLKALQRV TSTAQILLAY SMVMRALSQT
ASSFASASVS SQSNGLESLG LADIRILVRL MTLAAGGRAH ACVDNPPGVR GMVTERHRST
CFSFLTSAIG NVVSHSPSAY RQLVEICTQD LMAAATGVNI GAITEPQQRP TLTTSTQAAI
QQRDLGDQTP PTFLVTQHLV SLLTDKNIHS YSLDRTEHEA HGPLELANAL AACVLSARLT
SKHRQWAAQQ LVKALAAAGK ESPNRPQTYS DLAGDLHKCP LKRLEGHYNK VASCSWSSDQ
GLLATCSQDK VVQLWKVNQS TVELQTTFSC IVSKTDRSSS ERAGRCQHMS PVFWSTGGNF
LAAPENKHIN IMNIRGSLCH VEDQSSRVTA LCWAQSFHLW LLDQPAACKN RPGESLLVGR
LDGSLCWLQV TMQDLDLLVK RTELAHCHRQ EVAPHCVAWH SEDKPFAVGY PSGKILLGTT
ESYENTQPVV LSLFQDAVSC LKWDPTGHLL LCLGRSEVVK VLGRSGGTWV TLHSLYHTST
VNTAEWCPLA GRAPSPRLMM AVGCQNGSVY VWTLPQGGTS VSLPNILNSP QSQDQSFEVK
QDSAKCAFVL NGHITAVKSL SFCSSGLALV SGGIGGLLNI WSLQDGSVLQ TVTGLGSVVS
TTWIPNLGVA ACFGRSKDVL LICCTPDWIG ENHVLASCRM VLRSQNVLGL NRAPCLAVFL
ERLPLLLQEQ YSYERSHLAA GDQLVHSAFL QNLASLAVGL SLEKHLCSSP RPPHHAYPDA
QSCVSEWSWL LTYATTVRSA EAIASGTAFP ESFIVSGLLE VQDSNIVKAV DNSMWSFKMD
EQLMSWATSR PEDWQEGGKS EVYLWGNGRY GQLAGMGTNL TMPTVAPSLL QTQQVVCGQN
CTFLVQTNGT VLAVGEGQYG RLGQGNSDDL YVPTIISAFQ GYVVTQLVTS CGSDGHSMAL
TETGEVFSWG DGDFGKLGHG NSERQRRPKQ IEALQGEEVV QLACGFRHSA VVTADGKLFT
FGSGESGRLG LRSTSNKMLP ERVAALEGYH VGQVSCGLNH TLVVSLDGTI VWAFGDGDYG
KLGTGSSTAK YYPQKVEQLC NKGIKKVCCG TQFSVALSCD GHVYTFGQER LIGLPDPMLK
NKSTPQVVPS LEGLFVEDVA VGCEHVLALS STGDVYAWGC NSEGQLGLGH SNQVKEPTLV
TALQGKNIRQ ISAGRCHSAA WTTPSVLIKN SGGSGHLQLG LPQSVPPQYN TLKDCSPDVL
CMRLRVLYHF SDLMYKSWRL LNLDTKSQIS ASRYTSGAAA IIRGELRGLL SPKVNTLPLV
RSIGRTMTQG KTYGPQITVK RISTRGRSSK PIFVQIAKQV VNLNPLELRL PSRAWKVKLV
GEGADDAGGV FDDTITEMCQ QELQSGVVDL LIHTPNSFSD VGCNTDRFLL NPGAHSEDHM
VQFRFLGILM AVAIRTKKPL DLHMAPWVWK QLCCMPLSGA DLEEVDLLTY RTLQGILHLE
NSGITADNFH VMIPLDSFMA HSADGRLVPV VPRGQNISLT FSNRTEYVER ALDYRLHEMD
SQVDAVREGM STIIPVPLLS LLTAQQLEQL VCGLPEVSVE MLRKLVRYRD ITESHQLIRW
FWQSLKEFTN EERVLFLRFV SGRSRLPSNP ADISQKFQII KVDRRQPING LPTAQTCFFL
LRLPPYTSQA ILAERLRYSI HNCTSIDMDN YMLTHNTEPA ESSDTEE
//
