ID A0A087XMM1_POEFO Unreviewed; 512 AA.
AC A0A087XMM1;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=Integrator complex subunit 14 {ECO:0000256|ARBA:ARBA00016816};
DE AltName: Full=von Willebrand factor A domain-containing protein 9 {ECO:0000256|ARBA:ARBA00029992};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000007024.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000007024.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Probable component of the Integrator (INT) complex, a complex
CC involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and
CC in their 3'-box-dependent processing. {ECO:0000256|ARBA:ARBA00003473}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the INTS14 family.
CC {ECO:0000256|ARBA:ARBA00007451}.
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DR EMBL; AYCK01006710; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007556877.1; XM_007556815.2.
DR AlphaFoldDB; A0A087XMM1; -.
DR STRING; 48698.ENSPFOP00000007024; -.
DR Ensembl; ENSPFOT00000007036.2; ENSPFOP00000007024.2; ENSPFOG00000006991.2.
DR GeneID; 103141260; -.
DR KEGG; pfor:103141260; -.
DR CTD; 81556; -.
DR GeneTree; ENSGT00390000009486; -.
DR OrthoDB; 3673014at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0032039; C:integrator complex; IEA:InterPro.
DR CDD; cd00198; vWFA; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR039841; INTS14.
DR InterPro; IPR045814; IntS14_b-barrel.
DR InterPro; IPR046471; IntS14_C.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR13532:SF3; INTEGRATOR COMPLEX SUBUNIT 14; 1.
DR PANTHER; PTHR13532; UNCHARACTERIZED; 1.
DR Pfam; PF19435; IntS14_b-barrel; 1.
DR Pfam; PF20504; IntS14_C; 1.
DR Pfam; PF13519; VWA_2; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760}.
FT DOMAIN 3..117
FT /note="VWFA"
FT /evidence="ECO:0000259|Pfam:PF13519"
FT DOMAIN 209..356
FT /note="Integrator complex subunit 14 beta-barrel"
FT /evidence="ECO:0000259|Pfam:PF19435"
FT DOMAIN 404..511
FT /note="Integrator complex subunit 14 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF20504"
SQ SEQUENCE 512 AA; 56525 MW; 4721FA81EDCD4673 CRC64;
MPTVVLMDVS LSMTRPVSLD GIEEFQRKNL AVHGLNMLFE HMASNYRLEF TALMAFSSLW
ELLVPFTRDY NALQEALSNL EDYDKTCLEL ALQGVSSVVQ QEWGNGCPCQ VVLVTDGSLG
IGKGSLRHSL QTLKHRGDDK KFPLPYPFPT KMFILCIANA EELQMTDAME NLEELLRLSG
GDGQIFTVDG PLCMKSVQAM FGMLIDRAYS PFHAVLHCGN LSSDVQVFPR PEPVVVDEEV
EPIPKAVSTD LEIVGFIEIA DISSPPVISR HLVLPIAVNK EVDEVGTGAT DELEEEPSAS
QMAGKSPNFC VLLHGSLKVE GMVALVQLGP EWFGMLYSQA DSKKKSNLMM SLFEPGSDPL
PWLGKISHLG PVSEAAENPY GEDDSKSPFP VQPQVKRSYA QNVTVWIKAS GLQTDVQKIL
RNARKLPDKT QTFYKELNRL RKAALAFGFW ELLKGVAELL ERECTMLPDS AHPDAAFQLS
HAAHQLKLAS SGDSQYAAFD HNIVPMHTDF SS
//
