ID A0A087XPJ7_POEFO Unreviewed; 692 AA.
AC A0A087XPJ7;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000007700.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000007700.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AYCK01007025; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007557731.1; XM_007557669.2.
DR AlphaFoldDB; A0A087XPJ7; -.
DR STRING; 48698.ENSPFOP00000007700; -.
DR Ensembl; ENSPFOT00000007712.2; ENSPFOP00000007700.2; ENSPFOG00000007451.2.
DR GeneID; 103141862; -.
DR KEGG; pfor:103141862; -.
DR CTD; 60625; -.
DR eggNOG; KOG0922; Eukaryota.
DR GeneTree; ENSGT00940000156142; -.
DR OMA; FHEVMET; -.
DR OrthoDB; 5488182at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17980; DEXHc_DHX35; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF136; ATP-DEPENDENT RNA HELICASE DHX35-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760}.
FT DOMAIN 55..220
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 244..429
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 692 AA; 77880 MW; DD8605576070BBB7 CRC64;
MKFWKPGAEA PGISEERDLS SETTGSPFVF NPNTALSIEK QRQKLPVFKH RNNILYLVES
FQTVIIVGET GCGKTTQIPQ YLLEAGWAAE GKVIGVTQPR RVAAISVANR VAEERGALLG
HEVGYTIRFD DCSDPHATRI KFLTDGMLVR EMMADPLLKK YSVLMLDEAH ERTLYTDIAI
GLLKKIQKKR RDLRVIVASA TLDAKKFHEF FNLNETGDPN KDTCGILTVE GRTFPVDIFY
TVSPVPDYVK ATVETVMKIH EMEDDGDVLA FLTGQEEVEK VVSLLQEQAR ALSRYGMKKH
LRILPMYSGL PYADQMKVFE RAPSTVRKIV VATNIAETSI TITGIMFVID CAFVKLRAYN
PRTAIESLVV TPISKASASQ RAGRAGRNRP GKCFRLYTEE DYEKLPAATV PEMQRSNLAP
VILQLKALGI DNVLRFSFLS PPPAQTMVQA LELLYALGGL DHYGRLTDPL GMRMAEFPLS
PMFAKMLLES GNFGCSKEIV TIASMMQIQN IFVVPPNQKK DAAREHRKFA VAEGDHLTML
NVYEAFIKHQ KSSQWCQEHF LNYKGLLRAI TVREQLRRLM NKFKVARNSS EGDPDVILKC
IVSGFFANAA RIHHSGSYRT LRDDLELHIH PSSVLYGEKP PKWVVFNEVV QTSKYYMRDV
TAVESSWLVE LAPHFYKQAK HGSLASKRSR VL
//
