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Database: UniProt
Entry: A0A087XRX9_POEFO
LinkDB: A0A087XRX9_POEFO
Original site: A0A087XRX9_POEFO 
ID   A0A087XRX9_POEFO        Unreviewed;      2318 AA.
AC   A0A087XRX9;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 2.
DT   20-DEC-2017, entry version 21.
DE   RecName: Full=Voltage-dependent N-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000008532, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Ensembl:ENSPFOP00000008532, ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000008532};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000008532}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1B
CC       gives rise to N-type calcium currents. N-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-
CC       IIIA (omega-Aga-IIIA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing alpha-1B subunit may play a role in
CC       directed migration of immature neurons.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPFOP00000008532}.
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DR   EMBL; AYCK01007099; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01007100; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPFOT00000008544; ENSPFOP00000008532; ENSPFOG00000007325.
DR   GeneTree; ENSGT00830000128247; -.
DR   OMA; DSPRNNA; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005447; VDCC_N_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF161; PTHR10037:SF161; 2.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01631; NVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028760};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     89    106       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    127    148       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    160    180       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    215    238       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    291    312       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    324    346       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    471    490       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    496    514       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    596    618       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    674    696       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1123   1141       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1161   1181       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1193   1211       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1254   1276       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1366   1391       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1447   1465       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1477   1500       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1570   1588       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1659   1682       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1819   1853       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      389    409       {ECO:0000256|SAM:Coils}.
FT   COILED      692    719       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2318 AA;  262212 MW;  F680E7B9FDB35DCB CRC64;
     MARFEDDASS RFRGSGPTGP ARGANRQPGP PGGQRMYKQT MAQRARTMAI YNPIPVKQNC
     LTVNRSLFIF SEDNIIRKYA KKITEWPPFE YMILATIIAN CIVLALEQHL PALDKTPLSE
     RLDDTEPYFI GIFCFEAGIK IIALGFAFHK GSYLRNGWNV MDFVVVLTGI LATVGADFDL
     RTLRAVRVLR PLKLVSGIPS LQVVLKSIMK AMVPLLQIGM LLFFAILMFA IIGLDFYIGK
     FHRTCFKNGT NEQVADFPCG PEPPARTCGK GNICEEYWLG PNFGITNFDN ILFAILTVFQ
     CITMEGWVDI LYNANDASGN MWNWLYFIPL IIIGSFFMLN LVLGVLSGEF AKERERVEKR
     QEFLKLRRQQ QIERELTGYL EWICKAEEVM LAEEDKNAEE KSLDVLKRTK KSKNDLINAE
     EGEDHFTDIS SVGSPFARAS VKSKNESSSY LRRKEKRIRF TIRHLVKSQT FYWTVLCLVG
     LNTLCVAIVH YDQPEWLTYA LYLAEFVFLG LFLAEMTMKM YGLGPQSYFH SSFNCFDFGV
     IIGSIFEVVW AAIKPGASFG ISVLRALRLL RIFKVTKYWN SLRNLVVSLL NSMKSIISLL
     FLLFLFIVVF ALLGMQLFGG QFNFEDETPT TNFDTFPAAI LTVFQILTGE DWNAVMYHGI
     ESQGGVRRGM FSSIYFIILT LFGNYTLLNV FLAIAVDNLA NAQELTKDEE EQEEAISKKL
     ALQKAKEVQE VSPMLAANIS ITTNEQQRSV KTMSVWEQKA SQLRRHNQAS CEVLYDPEEC
     VRLPSGLQMR PDMKTHLDRP LVVGHSDGLL VRGHQHHRHK PGTPEEAETA ADPPSAPPHS
     HHRHHRHRDR GRAKVKEEPN DSGGDSGKDG RQHVHHSHSK NHDYSCRQEG KSGRSCSTDR
     SRKHHHHSSM DESAGEREHR HHHSHRQSRG GNGTVNGGGR GEHRVHRKDG RSSNKDGERE
     GKRRRHHTHG SRSQSRAEGE ESIEREEPNT NRTTVAHHGI KLHKPPSLLV LDKRGALNIR
     KSTSPNHHSN LMPKCPEDSD NQKNVRRTGQ TSIRIPPVTI TTPGEITMIQ MNTDNESMPM
     NEKNLKDQYH SGPRPILPYS SMFIFGQTNP VRRLCHYIVT LRYFEMSILV VIAMSSIALA
     AEDPVWTNAP RNNVLKYLDY AFTGVFTFEM VIKMVDLGLL LHPGSYFRDL WNILDFIVVS
     GALVAFAFSG TKGKDISTIK SLRVLRVLRP LKTIKRLPKL KAVFDCVVNS LKNVLNILIV
     YILFMFIFAV IAVQLFKGKF FYCTDESKAL EKDCKGQFLD YDKETVAAMP REWKKYEFHY
     DNVLWAFLTL FTVSTGEGWP TVLKHSVDAT FEDQGPSPGY RIEMSIFYVV YFVVFPFFFV
     NIFVALIIIT FQEQGDKALS ECSLEKNERA CIDFAINAKP LTRYMPEDTQ SFQYRMWKFV
     VSAPFEYSIM IMIALNTVVL MMKFHGAPDF YEAMLKYLNI VFTTLFSLEC ILKIIAFGPL
     NYLKDAWNVF DFVTVLGSIT DILVTEIKTT DRLLNLSFLR LFRAARLIKL LRQGYTIRIL
     LWTFVQSFKA LPYVCLLIAM LFFIYAIIGM QVFGNIELNE DTAINHHNNF RTFLQALMLL
     FRSATGEAWH EIMLSCLSHR PCDELSGTSG KDCGSDFAYF YFVSFIFLCS FLMLNLFVAV
     IMDNFEYLTR DSSILGPHHL DEFIRVWAEY DPAACGRISY MDMYNLLRVI SPPLGLGKNC
     PNRVAYKRLV KMNMPIADDN TVHFTSTLMG LIRTALEIKL ASGMVLQRLM DAELRKEMST
     VWPSLSQKTM DLLVTPHKPN ELTVGKVYAA LMIFDYLKQN RASMSPSISP PQCKVEALFK
     PLLPLTHMQG SPSAPQSQQS LESFRQVVSS NSINNGGMLP GYDPRNKSVP STGMERPTEG
     VYPKPKRTIS KGPSVDTSNV VNQESVGLNS VSSTVPVPGP GPGLESQGRA ASMPRLNVEL
     QLLKAQNLTK LLQSGRDASS MRRSVTTVAP QRPQEVNLRN YTLEKPRHER THHHHHHHHC
     HHRRDRDKDK RQGSLDTPFG GQPPNSAGQS ANSTCRERAH KRGRSHERKH HHSSADKQRY
     YSCDRYCSRE RCCPKSATAA CSYREEQETS KKQGSGLVKG SPDASRSGSS TLSRGRRQLP
     QVPHTPRPGV GYKTAYPSQV HFVSSQASQS PGRLSRGLSE HNTLRHSGSY YFPCPVTRIS
     SEPFLGQGHG DALGSPYSSF QNQLDVFQDV ASLSPTPSAE QSPRTTLPRM MGALHPTFGV
     DPSVPNGYHL SLGGSTSPGT GYRALRYRSH CGENELWC
//
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