ID A0A087XSX8_POEFO Unreviewed; 1668 AA.
AC A0A087XSX8;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Transient receptor potential cation channel, subfamily M, member 3 {ECO:0000313|Ensembl:ENSPFOP00000008881.2};
GN Name=TRPM3 {ECO:0000313|Ensembl:ENSPFOP00000008881.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000008881.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000008881.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AYCK01000930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 48698.ENSPFOP00000008881; -.
DR Ensembl; ENSPFOT00000008893.2; ENSPFOP00000008881.2; ENSPFOG00000008426.2.
DR eggNOG; KOG3614; Eukaryota.
DR GeneTree; ENSGT00940000157366; -.
DR OMA; XVIRHVG; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR Gene3D; 1.20.5.1010; TRPM, tetramerisation domain; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR InterPro; IPR032415; TRPM_tetra.
DR InterPro; IPR037162; TRPM_tetra_sf.
DR PANTHER; PTHR13800:SF7; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 3; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
DR Pfam; PF16519; TRPM_tetra; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 716..734
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 817..836
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 884..902
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 914..932
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 953..973
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1031..1056
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 96..361
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 826..1065
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1157..1211
FT /note="TRPM tetramerisation"
FT /evidence="ECO:0000259|Pfam:PF16519"
FT REGION 745..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1366..1391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1517..1647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..768
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1524..1544
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1573..1589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1668 AA; 187273 MW; 540161A56793C5AA CRC64;
LMQAQKSWIE RAFSKRECVH IIVSAKDPHR CCCGRLIGQH VGLPPGISSS QNDKAERLAK
NDSLSEKWSI SKHTQLSPTD AFGTIEFQGG GHSNKAMYVR VSYDTKPDLL LHLMTKEWQL
ELPKLLISVH GGLQNFELQP KLKQVFGKGL IKAAMTTGAW IFTGGVNTGV IRHVGDALKD
HASKSRGKIC TIGIAPWGIV ENQEDLVGKD VVRPYQTMSN PMSKLTVLNS LHSHFILADN
GTTGKYGAEV KLRRQLEKHI SLQKINTRIG QGVPVVALIV EGGPNVISIV LEYLRDTPPV
PVVVCDGSGR ASDILAFGHK YSEEGGIINE SLRDQLLVTI QKTFTYSRTQ AQHLFIILME
CMKKKELITV FRMGSEGHQD IDLAILTALL KGANASAPDQ LSLALAWNRV DIARSQIFIY
GQQWPVGSLE QAMLDALVLD RVDFVKLLIE NGVSMHRFLT LSRLEELYNT RHGPSNTLYH
LVRDVKKGNL PPDYRISLID IGLVIEYLMG GAYRCNYTRK RFRTLYHNLF GPKRPKALKL
LGMEDDMPIR RGRQKTTRKR EEEVDIDLDD PEINHFPFPF HELMVWAVLM KRQKMALFFW
QHGEEAMAKA LVACKLCKAM AHEASENDMV DDISQELNHN SREFGQLAVE LLDQSYKQDE
QMAMKLLTYE LKNWSNATCL QLAVAAKHRD FIAHTCSQML LTDMWMGRLR MRKNSGLKVI
LGLLLPPSIL SLEFKNKDEM SYMPQDQDTY LQEKEEEEPE KPVKEKEEED MEFTAMLGKV
TTETSRKKDV EEVQSRHRLI PMGRKIYEFY NAPIVKFWFH TMAYVGYLML FNYIVLVKMD
LWPSPQEWIV IAYIFTNGIE KMREILMSEP GKLLQKVKVW LQEYWNITDL MAILIFSVGM
VLRLQEPPLM SYGRVIYCVN IIYWYIRLLD IFGVNKYLGP YVMMIGKMMI DMMYFVIIML
VVLMSFGVAR QAILNPNEDP SWMLARNIFF MPYWMIYGEV FADQIDPPCG QNITTEDGVV
VTLPPCKTGA WIVPAIMACY LLVANILLVN LLIAVFNNTF FEVKSISNQV WKFQRYQLIM
TFHERPVLPP PLIIFSHITM VLKHLCCRWR KHDDDERDYG LKLFITEDEL KKVHDFEEQC
IEEYFREKDD RFHSSNDERI RVTSERVENM AMRLEEVNER EHFMKASLQT VDIRLAQMED
LIGRIAVALE RVTGVERVEV NKARSRTSSD CTDSAYILRQ GSFNSTEGNA YRLQEALEGA
AEGSISPPSP TGITARARSH SFYVGGGRAV ERASGAERAE SFFKERSLSL HRANSSQSVS
SAAATKESKP LPLATLSVSQ QHRPSSCIDI YVSTSEESDI METVLPGGRD FSSTATSGLG
DRHSEGAAGS SVTTGAMYDD SAAADLSLCS ASLLPDTTLP PWDTEPSPPP SAGLLERSKS
SRYLSTAGTA FLDEPPLVKS HSLMFTPRGC YGGLGAGVQV KAAEYTSITD CIDTRCVSSP
YTPAECSHLP GGSTSFTFDK PSDISSSHPE REAELSHTES DPEDPEDLIP ASDAPRITGL
GGPSGAPLCS TLSRLERANS CSSDDSHPSL TLAPPHRKSL SVSERMERGP GLGADRGSGP
GGRGLAGHRY PFLRSKSGAR PDAAKTDSLS IRKLAAPSAF RSFDRQNY
//
