ID A0A087XTS7_POEFO Unreviewed; 780 AA.
AC A0A087XTS7;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Suppressor of cytokine signaling 7 {ECO:0000313|Ensembl:ENSPFOP00000009180.1};
GN Name=SOCS7 {ECO:0000313|Ensembl:ENSPFOP00000009180.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000009180.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000009180.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AYCK01015637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01015638; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A087XTS7; -.
DR STRING; 48698.ENSPFOP00000009180; -.
DR Ensembl; ENSPFOT00000009192.2; ENSPFOP00000009180.1; ENSPFOG00000009160.2.
DR eggNOG; KOG4566; Eukaryota.
DR GeneTree; ENSGT00940000156314; -.
DR OMA; EPDELMS; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd10388; SH2_SOCS7; 1.
DR CDD; cd03741; SOCS_SOCS7; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035866; SOCS7_SH2.
DR InterPro; IPR037346; SOCS7_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF5; SUPPRESSOR OF CYTOKINE-SIGNALING 7; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 595..715
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 701..751
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 28..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 131..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 481..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 761..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..343
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..358
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..432
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 780 AA; 83127 MW; A421A890E4F4C2D8 CRC64;
MNDAQQEMSP DFVLMRLVSA AEYDRLDEPD DLIRSGGGGF GPVKAALGHH GGGSPLPGKG
ELEGGLGLSQ GPASSEAPLS PPPEDFAAAA QRFVDGSAGH GSRAQLMVLQ NLLRSGLEQP
SPAGFLQEEP ERQKLEPGPG SGSASTAGFR PGGGLSKGSD GPQNPPPVPA LDPESIPILC
HRHRLAKWPP GLLDQALRLG LLELRRTCPS GAEDPVLVLA QKLGQLGEGR EGLGEGDRVP
LSPRCSCHSI LAAGPVAPGD DPSDTSDALL VLEGLGSEQV GELPAGTVFS AGTLSGLMRQ
VHRLAEEAGV CTEPTCRAAA TPPAAPQGPP ATGAAPPDPG PRPQHQHQSR SQPQSRAATP
KLGVAAGGAG RAASPLTVLE GGNDRTPRRK SRKGGSLKVR LSKLFRTKSS SGGSGGLLDK
RPSLASSTSS GGSLLDVWGS TCSSTDQDRL QVSRPHSAFS PVPFTPAFTG ETVSLVDVDI
SRRGGSAQPP RRSLSLLDDF GGPPQHQGPF TERSAGASMQ SLPPRPLALH PTLSTIQHSL
SLNVVFTQNA LHCSSLPAFG AVSSQVAFRH VFSWTGSEVS GSFATSLREL EKCGWYWGPM
NWEDAEMKLK GKPDGSFLVR DSSDPRYILS LSFRSQGVTH HTRMEHYRGR TFSLWCHPKF
EDRCHSVVEF IERAIMHSKN GKFLYFLRSR VPAGLPPTPV QLLYPVSRFS SVKSLQHLCR
FCIRQLVRID HIQELPLPTP LIAYLRKFYY YDPEEEISAA LPDRKEAREP SSQPGVRSQT
//
