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Database: UniProt
Entry: A0A087XU51_POEFO
LinkDB: A0A087XU51_POEFO
Original site: A0A087XU51_POEFO 
ID   A0A087XU51_POEFO        Unreviewed;       850 AA.
AC   A0A087XU51;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   07-JUN-2017, entry version 13.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000009304, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Ensembl:ENSPFOP00000009304, ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000009304};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000009304}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPFOP00000009304}.
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DR   EMBL; AYCK01007726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_007559181.1; XM_007559119.2.
DR   Ensembl; ENSPFOT00000009317; ENSPFOP00000009304; ENSPFOG00000009154.
DR   GeneID; 103142850; -.
DR   CTD; 23545; -.
DR   GeneTree; ENSGT00390000004941; -.
DR   OMA; TIPSFMN; -.
DR   OrthoDB; EOG091G01BI; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028760};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    409    432       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    453    472       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    548    566       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    578    601       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    640    660       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    778    803       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    121       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   850 AA;  97935 MW;  A2C602EC49EB0565 CRC64;
     MSSLLRGEEM CLAQLFLQSG SAYDCISELG EMGLVEFRDL NPNVNSFQRK HVNEIKKCEE
     MERILGYLLR EIKKADISLP ERDMNPVAPS PKHIMTIMEQ LQRLEVELGE VTRNKEMLQK
     NLLELTEYTH MLRITRSFVQ RNAEREPLQV QYEEFPFLEK DTRMDYSSMQ RLGAKLGFIS
     GLIQRAKIEA FERMLWRVCK GYTILSYAEV EEYLEDPDTG EPTKSVVFLI SYWGDQIGQK
     VKKICDCYHC HLYPYPSNND ERNDVVEGLR TRIQDLHTVL HRTEDYLRQV LIKASESVYT
     WVVQVKKMKA IYYILNLCSF DVTNKCLIAE VWCPVNDIPK LRRALEDGSR KSGATVPSFV
     NRIPTTDTPP TLIRTNKFTS GFQNIVDAYG VGSYREVNPA PFTIITFPFL FAVMFGDLGH
     GIIMSLFALW MVRYENNRKL KNTRNEIWNT FFEGRYIILM MGLFSIYTGL IYNDCFSKSL
     NIFGSGWSVP AMFKANVWTP KDLRGNHFLT LDPNVTGVFK GPYPFGIDPI WNLASNRLTF
     LNSYKMKMSV ILGVTHMSFG VILSTYNHRY FRKRYNLYLV FLPELLFLLC LFGYLVFMIF
     YKWLVFTAKD SKKAPSILIH FINMFLMQGE EVQPLYPGQI GLQIFLVVIA VLSVPVLLLG
     KPVYLRWLQN GGQNRLGLYR GYERVRRSSV EELCLLRSED MEEGSSHSDL SSSGEHLSEE
     FNFADEFLHQ AIHTIEYCLG CISNTASYLR LWALSLAHAQ LSEVLWAMVM RVGLQMDTAL
     GVVILLPAFG LFAVLTVSIL LIMEGLSAFL HALRLHWVEF QNKFYSGTGV KFCPFSFSLL
     PSSFEHDGLL
//
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