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Database: UniProt
Entry: A0A087XXJ1_POEFO
LinkDB: A0A087XXJ1_POEFO
Original site: A0A087XXJ1_POEFO 
ID   A0A087XXJ1_POEFO        Unreviewed;       840 AA.
AC   A0A087XXJ1;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 2.
DT   28-MAR-2018, entry version 16.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000010494, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Ensembl:ENSPFOP00000010494, ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000010494};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000010494}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; AYCK01000695; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01000696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01000697; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPFOT00000010509; ENSPFOP00000010494; ENSPFOG00000010533.
DR   GeneTree; ENSGT00390000004941; -.
DR   OMA; WTAYDAH; -.
DR   OrthoDB; EOG091G01BI; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0071466; P:cellular response to xenobiotic stimulus; IEA:Ensembl.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028760};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    401    425       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    445    464       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    544    565       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    571    595       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    636    656       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    774    796       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    121       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   840 AA;  95497 MW;  2691BD13AC601C2F CRC64;
     MGELFRSEEM TLAQLFLQSE AAYCCVSELG ELGMVQFRDL NPDVNVFQRK FVNEVRRCEE
     MDRKLRFVEK EIKKASIPMV DTGENPEVPF PRDMIDLEAT FEKLENELKE INTNQEALKK
     NFLELTELKH ILHRTQQFFD EMEDPNLLEE SSALMEGSEG GRGAPLRLGF VAGVISRERI
     PTFERMLWRV CRGNVFLRKA EIEDPLEDPA SGDQVHKSVF IIFFQGDQLK NRVKKICEGF
     RASLYPCPET PQERKEMLAG VNSRIEDLQM VLNQTEDHRQ RVLQAASKTM RVWFIKVRKM
     KAIYHTLNLC NIDVTQKCLI AEVWCPVSDL DSIQFALRRG TERSGSTVPS ILNRMQTKQT
     PPTFNKTNKF TSGFQNIVDA YGIGNYREIN PAPYTIITFP FLFAVMFGDM GHGVLMTAAA
     LYLVLRESRI LAQKSDNEMF NMVFAGRYII LLMGIFSVYT GIIYNDCFSK SLNMFGSGWS
     VRPMFSPKGA NWSSETLDGN AVLQLDPAVP GVFNGPYPLG IDPIWNVATN KLTFLNSFKM
     KMSVILGVIH MLFGVSLSLF NHLYFKKPLN IFLGFIPEIV FMSSLFGYLI LLIFYKWTAY
     DAFTSKDAPS LLIHFINMCL FNYNDPTNKP LYAGQMGIQV LLVLIALACV PCMLIVKTMV
     LRRQHLWKRH LGTQKFGGVR VGNGPTEDEA GIMDHDQLSQ HSDEGDEHSE EEPFNFGDVA
     VHQAIHTIEY CLGCISNTAS YLRLWALSLA HAQLSEVLWS MVMHLGLSSR SGGGFFGLSI
     IFSAFATLTV CILLIMEGLS AFLHALRLHW VEFQNKFYTG QGFKFVPFSF ESILEGRFDD
//
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