ID   A0A087XZJ8_POEFO        Unreviewed;       755 AA.
AC   A0A087XZJ8;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 2.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=RUN and TBC1 domain-containing protein 3 {ECO:0000256|ARBA:ARBA00030864};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000011201.2, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000011201.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the small G protein signaling modulator family.
CC       {ECO:0000256|ARBA:ARBA00006296}.
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DR   EMBL; AYCK01009527; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_007562953.1; XM_007562891.2.
DR   RefSeq; XP_007562955.1; XM_007562893.2.
DR   AlphaFoldDB; A0A087XZJ8; -.
DR   STRING; 48698.ENSPFOP00000011201; -.
DR   Ensembl; ENSPFOT00000011217.2; ENSPFOP00000011201.2; ENSPFOG00000011117.2.
DR   GeneID; 103145450; -.
DR   KEGG; pfor:103145450; -.
DR   CTD; 27352; -.
DR   eggNOG; KOG2222; Eukaryota.
DR   GeneTree; ENSGT00940000157282; -.
DR   OMA; QKWYQPW; -.
DR   OrthoDB; 12479at2759; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   CDD; cd17688; RUN_SGSM3; 1.
DR   CDD; cd11813; SH3_SGSM3; 1.
DR   Gene3D; 1.20.58.900; -; 1.
DR   Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR   Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR   InterPro; IPR000195; Rab-GAP-TBC_dom.
DR   InterPro; IPR035969; Rab-GAP_TBC_sf.
DR   InterPro; IPR004012; Run_dom.
DR   InterPro; IPR037213; Run_dom_sf.
DR   InterPro; IPR035833; SGSM3_SH3.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR47219; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR   PANTHER; PTHR47219:SF19; RUN AND TBC1 DOMAIN-CONTAINING PROTEIN 3; 1.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   Pfam; PF02759; RUN; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   SMART; SM00593; RUN; 1.
DR   SMART; SM00326; SH3; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF140741; RUN domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR   PROSITE; PS50826; RUN; 1.
DR   PROSITE; PS50002; SH3; 1.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          115..306
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000259|PROSITE:PS50086"
FT   DOMAIN          484..543
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          559..722
FT                   /note="RUN"
FT                   /evidence="ECO:0000259|PROSITE:PS50826"
FT   REGION          53..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   755 AA;  86180 MW;  6355AD031EB5EE1C CRC64;
     MSGTYTPAPG GSFSALTPSM WPQDILAKYH QKDPAEQPEQ QYDEFGFRID VEDDGEPKIR
     LGTEGSPQRE DPQQRLRWQA HLEFTHNHTV GDLTWDLIDP VLPQSERLRS LVLGGIPHSM
     RPQLWMRLSG ALQKKRTSEI SYKEIVKNSS NDDTSTAKQI EKDLLRTMPT NACFSTLNSV
     GVPRLRRVLR GLAWLYPDIG YCQGTGMVIS CLLLFLEEED ALWMMCALIE DLLPPSYFSS
     TLLGVQTDQR VLRQLTVQYL PALDRLLQEH DIELSLITLH WFLTSFASVV DIRLLLRIWD
     LLFYQGSVVL FQITLGMLKI KEEELVASEN SASIFNTLSD LPSQLKDGPA VLGEAMRIAG
     TLSQETLEAH RHKHLAYILN EQAQLNNGNN STLSTNLNKV VRRQSLRRKS TLTSLLFGED
     EADALKSKNI KQTELVAALR EAITRTAEHF HCLDPRHSST DLTPDYSMES HQRDHENFLV
     VSRNRRRRAK ALLDFERHDD DELGFRKNDI ITIISQKDEH CWVGELNGLR GWFPAKFVEI
     LDERSKEYSL AGDDSVTEAV TDLVRGTLCP ALKAIFQHGL KKPSILGGPC HPWLFIEEAA
     SREVERDFNS VYSRLVLCKT YRLDEDGKVL TPEELLYRAV QAVNMSHDSV HAQMDVKFRS
     LVCVGLNEQV LHLWLEVLCS SMAAVEKWYH PWSFLRSPGW VQIKCELRVL SKFAFSLSQD
     SELPEKKVEK EQKPLKEGVQ DMLVKHHLFS WDIDG
//