ID A0A087Y2N0_POEFO Unreviewed; 687 AA.
AC A0A087Y2N0;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Tumor necrosis factor receptor superfamily member 21-like {ECO:0000313|Ensembl:ENSPFOP00000012283.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000012283.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000012283.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR EMBL; AYCK01017309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01017310; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A087Y2N0; -.
DR STRING; 48698.ENSPFOP00000012283; -.
DR Ensembl; ENSPFOT00000012300.2; ENSPFOP00000012283.2; ENSPFOG00000012290.2.
DR eggNOG; ENOG502QVMX; Eukaryota.
DR GeneTree; ENSGT00940000156212; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd10583; TNFRSF21; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR022330; TNFR_21.
DR InterPro; IPR034034; TNFRSF21_N.
DR PANTHER; PTHR46921; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 21; 1.
DR PANTHER; PTHR46921:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 21; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF00020; TNFR_c6; 2.
DR PRINTS; PR01971; TNFACTORR21.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM01411; Ephrin_rec_like; 2.
DR SMART; SM00208; TNFR; 4.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF57586; TNF receptor-like; 3.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..687
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001833888"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 76..117
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 76..117
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 436..519
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 295..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..311
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 77..92
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 99..117
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 687 AA; 74705 MW; 65C341D96B79964D CRC64;
MMSVIHVSAV LLCTVVADIS ARALTTSTAD DQPLLSPRHY QHTDRDSGTQ LVCDKCPAGT
YVSVHCSPTT VRECSPCPSG TFTRGENGVQ QCHRCRAPCP AGFIEKAPCM ATQDRVCTCP
PNTFLLKSGG LECKPHSLCP PGTRVKRRGN EKEDVLCKPC TKGTFSQVES SAMSCRNHTD
CKALARLLLT PGTRQTDNVC GPPSATLSSV PPTTPLGPAQ AVFVQETIMS SVSPSLNGHE
RKDPLSQSAA IQLRKAVGGE DGGVELMLTH SGVPTPPNQE ASWTPLSVAR KQAMDLKQEL
GKSDADPEPG ANKPRMEGPV GPEVVRVGTS ISNVVNSGNA GEASNYYRPN RRGSPRPTMH
DHFDINEHLP WMIVLLLLLV LVVIVVCSVK RSSRVLKKGP MQDPSSIMEK AIHKKTSGTP
TQAREKWIYY YSNGQGVDIL KLVAAQVGNQ WVDIYQSLAN ATEREVAAFS NGYSSDHERA
YAALQHWTIR DSGANLAKLI NALHRLRRID VVEKIRCVME DNPQFDINQL TTTVNVSQSL
SPIHKLLESP SSSGSSSSGG SMYRAGGVGP VQSPMDRTKG FFADESEPLL RCDSTSSKDS
ALSRNGSFIT KEKKDTVLRQ VRLDPCDLQP IFDDMLHILN PEELHVLEEI PTAEDKLDRL
FEIAGVKSQE ASQTLLDSVY SHLPDLL
//