ID   A0A087Y2U1_POEFO        Unreviewed;       701 AA.
AC   A0A087Y2U1;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000012344.1, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000012344.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the nicastrin family.
CC       {ECO:0000256|ARBA:ARBA00007717}.
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DR   EMBL; AYCK01004651; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_007552066.1; XM_007552004.2.
DR   AlphaFoldDB; A0A087Y2U1; -.
DR   STRING; 48698.ENSPFOP00000012344; -.
DR   Ensembl; ENSPFOT00000012361.1; ENSPFOP00000012344.1; ENSPFOG00000012361.1.
DR   GeneID; 103137971; -.
DR   CTD; 23385; -.
DR   eggNOG; KOG2657; Eukaryota.
DR   GeneTree; ENSGT00390000014633; -.
DR   OMA; ECVYPGV; -.
DR   OrthoDB; 1330770at2759; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0016485; P:protein processing; IEA:InterPro.
DR   CDD; cd03881; M28_Nicastrin; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR041084; Ncstrn_small.
DR   InterPro; IPR008710; Nicastrin.
DR   PANTHER; PTHR21092; NICASTRIN; 1.
DR   PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR   Pfam; PF18266; Ncstrn_small; 1.
DR   Pfam; PF05450; Nicastrin; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..701
FT                   /note="Nicastrin"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5001833904"
FT   TRANSMEM        662..682
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          39..213
FT                   /note="Nicastrin small lobe"
FT                   /evidence="ECO:0000259|Pfam:PF18266"
SQ   SEQUENCE   701 AA;  77873 MW;  E962C87B8129F25D CRC64;
     MDLLSNKWIV YLALCLFVGG VSCNSVENKI YVKLNYTVPC VRLLNSTHQI GCQSSLSGDV
     GVLHVLESEE NLDFVLRSGR NPPYMVIMES SLFTRSVMMK LKNGSGRVAG VAVVEPTSNP
     PDGFSPHTRC PNENTGVYSE NYGPGLAHCN TTKWNPLGNG LSYEEFDFPI FSMKDDNDTQ
     LIRQCYMDHN RPVNGSHPQY PLCAMQLSSH MSAVTNTPTC MRRNSISFSM SNEMVCDPLS
     DQNIWAPSKP LNITQNGHKA DESVIIVSAR LDSRSFFSEI GPGAESAASG LITLLAAAHA
     LRNATQDAQL DRTIFYTFFH GETFDYIGSS KMVYDMEKNQ FPIDLDNVHS VLEIGQVGFY
     SSSNLWLHTD PVSMRNSSIQ KEVKNLIDNL NSAAVGLNVS VKEPGVTQPL PPSSFQRFLR
     ARPFPGVVIE DYNSSFSNKY FQSMFDNADS LNVLYPPNLT PEEQLNHVTD TAKSLAEVAT
     MVARALFLQA GGKKTQISSI KADELTVSRM LYSFLISSNN SWTQEIVAPK DIVHLNNNTV
     NFYISVEQQA SLPTILAKYL LANLTGSVVN VTQENCRNQK ESEDDKESKH LYNYIWVQGA
     ALPNSTERDG FCVRSTVHWS RAISPAFELE NYTTSEYSTW TESRWKEIKG RIFLVASHDL
     EMLTLGVGIG VLLSSLLLTY IMSSKADILF SSGREPTSAT Y
//