ID A0A087Y481_POEFO Unreviewed; 1824 AA.
AC A0A087Y481;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Sucrase-isomaltase, intestinal-like {ECO:0000313|Ensembl:ENSPFOP00000012834.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000012834.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000012834.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000256|ARBA:ARBA00004655}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004655}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004401}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004401}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 31 family.
CC {ECO:0000256|ARBA:ARBA00007806}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00779}.
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DR EMBL; AYCK01016296; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01016297; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01016298; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 48698.ENSPFOP00000012834; -.
DR Ensembl; ENSPFOT00000012851.2; ENSPFOP00000012834.2; ENSPFOG00000012686.2.
DR eggNOG; KOG1065; Eukaryota.
DR GeneTree; ENSGT00940000164162; -.
DR OMA; ARWYDFH; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0090599; F:alpha-glucosidase activity; IEA:UniProt.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06602; GH31_MGAM_SI_GAA; 2.
DR CDD; cd14752; GH31_N; 2.
DR CDD; cd00111; Trefoil; 2.
DR Gene3D; 3.20.20.80; Glycosidases; 2.
DR Gene3D; 2.60.40.1760; glycosyl hydrolase (family 31); 2.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 4.
DR Gene3D; 4.10.110.10; Spasmolytic Protein, domain 1; 2.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR030458; Glyco_hydro_31_AS.
DR InterPro; IPR048395; Glyco_hydro_31_C.
DR InterPro; IPR030459; Glyco_hydro_31_CS.
DR InterPro; IPR025887; Glyco_hydro_31_N_dom.
DR InterPro; IPR000322; Glyco_hydro_31_TIM.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR017957; P_trefoil_CS.
DR InterPro; IPR000519; P_trefoil_dom.
DR InterPro; IPR044913; P_trefoil_dom_sf.
DR PANTHER; PTHR22762; ALPHA-GLUCOSIDASE; 1.
DR PANTHER; PTHR22762:SF168; P-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13802; Gal_mutarotas_2; 2.
DR Pfam; PF01055; Glyco_hydro_31_2nd; 2.
DR Pfam; PF21365; Glyco_hydro_31_3rd; 2.
DR Pfam; PF00088; Trefoil; 2.
DR SMART; SM00018; PD; 2.
DR SUPFAM; SSF51445; (Trans)glycosidases; 2.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 2.
DR SUPFAM; SSF51011; Glycosyl hydrolase domain; 2.
DR PROSITE; PS00129; GLYCOSYL_HYDROL_F31_1; 1.
DR PROSITE; PS00707; GLYCOSYL_HYDROL_F31_2; 1.
DR PROSITE; PS00025; P_TREFOIL_1; 1.
DR PROSITE; PS51448; P_TREFOIL_2; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Sulfation {ECO:0000256|ARBA:ARBA00022641};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 55..101
FT /note="P-type"
FT /evidence="ECO:0000259|PROSITE:PS51448"
FT DOMAIN 927..971
FT /note="P-type"
FT /evidence="ECO:0000259|PROSITE:PS51448"
SQ SEQUENCE 1824 AA; 207607 MW; E77180C49B8FDDFE CRC64;
MQRRGKMGKK RWTTTEIILL ILFILMTILA VTMIALFITK EPGTISDETA DGFIPQCPNI
PMSERVDCYP DPGASKTGCE QRGCCWSPLD ERNVPWCFFP TNHGYMVHSL QTPKPTELHV
EMKRMASPSL FGGDIQELTL HAEMQTNNRL HFKIYDTKST RFEVPHEHIP TVTSSPSSDI
SETLEIRNNP FGLVVRRKEN KKVLFDTTMA PLVFADQYIQ LSAKLPSHNI YGLGEHVHQT
YRHDTNWRTW PIFTRDAFPN GGTHNLYGHY PFFLCLEDES GKSFGVFLLN SNAMEVTLQP
APAVTYRTIG GVLDFYILFG DTPEDVVHEF LQLIGMPVIP AYWSLGFQLS RWNYGSLDEV
KATVERNRAI GLPYDIQYTD IDYMEDKKDF TYDKEKFKDL PGFADYLHEK GQKYILILDP
AIATSKRVGG APYESYDRGT QQNAWVFESD GKTPLVGEVW PGETVFPDYT SQKCIDWWID
EYVRFSKEVK HDALWIDMNE VANFKQGSNK GCAKNKLNYP PYTPKILDDV MYSKTLCMDA
KQAWGNHYDV HSLYGYSMVL ATEKALQQVF GSNRTLMLTR SSFPGVGKYS GHWLGDNGAN
WNDIKWAIPG MLEFGLFGVP YIGADICGFF DNSTEELCRR WMQVGAFYPF SRNHNAEGYM
PQDPAYYGAD SMLVKSSKHY LNIRYTLLPY LYTLFYKAHT TGETVVRPLL HEFYSDSATW
DVDRQFLWGK HLLITPVLEP GMDRVSAYIP DALWYDYDTM ERIEDRKTRV DMYLPADKLG
LHIRGGAILP TQEPDVTTTH SRRNPMGLIV TLDDNNQAAG ELFWDDGDSR DTVKDGNYIH
YQFSFANGRL NLQVTHAGYK DPNNLKFEKI TIMGVPNLPP SVSVTHMPSG SVTQLPSSSF
YHDATKQVLF LSNLGLSLGE SYTVQFDMIS DELQRFDCHP EDNADETKCK ARGCLWQTST
IEKVPWCYYP SDYGYTVTTT SETSTGMTLD ITRNMKYRSS GRPGSPDVNN LRVQIWYHAS
DMLQFKIWDP TADRFEVPVP LSVPSTPEAD ESKRLYKVSV TQNPFGIQVV RKSTGTKIWD
SAIPGFTFSD LFIQVSTRLS SNFVYGFGET EHTTYRHDLN YHTWGMFSKD QPPGYKMNCY
GVHPFYMGLE DTADAHGVLL LNSNAMDVTF QPTPALTYRT IGGILDFYMV LGPTPEMVVQ
EYTTLIGRPV LPAYWSLGFQ LCRYGYADDS EIEELYRGMK AARIPYDVQY ADIDYMERQL
DFVLDSQFQN LPRLVDDMRA EGMRFIFILD PAISGNETVY PAFTRGKAAD VFIKWPSHLS
NDIVWGKVWP DFPNVVVDES LDWDTQVEIY RAYTAFPDFF RTQTAAWWKQ EIQDFYNKMK
FDGLWIDMNE PASFVHGTVG GKCLGNPLLE NPPYMPPLES SHMGLNHKTL CMNSEQILSN
GKKVAHYDVH NLYGWSHTKP TFDALLEVTG KRGIVVTRST YPTSGKWAGH WLGDNNSSWD
QLFKSIIGMM EFSLFGISYT GADICGFFNP AEYEMCLRWM QLGAFYPYSR NHNGKGNPRQ
DPVAWDNRFA EASRDVLNIR YTLLPYLYLL MFEAHTKGST VVRPVLHEFV KDKATWDIYK
QFLWGPALLI TPALDPGVTE VEGYLPDARW YDYHTAKNVG KRATKVSMNT PLEHINLHVR
GGYILPWQKP ENNTFYSRKN PMGLIVALSD SGTAQGSVFW DDGEGIDTVG KNQYLLTSVK
AEEKTLSSQI VHNALDPADH LILGVVRVWG AGTVKITGAT LTDKDGATHS LSVTHDTNTE
ELTIDVTSKA VPLHHPFSIT WKTG
//
