ID A0A087Y6H9_POEFO Unreviewed; 826 AA.
AC A0A087Y6H9;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=PMS1 homolog 2, mismatch repair system component {ECO:0000313|Ensembl:ENSPFOP00000013632.2};
GN Name=PMS2 {ECO:0000313|Ensembl:ENSPFOP00000013632.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000013632.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000013632.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; AYCK01000711; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007558945.1; XM_007558883.2.
DR AlphaFoldDB; A0A087Y6H9; -.
DR STRING; 48698.ENSPFOP00000013632; -.
DR Ensembl; ENSPFOT00000013651.2; ENSPFOP00000013632.2; ENSPFOG00000013622.2.
DR GeneID; 103142711; -.
DR KEGG; pfor:103142711; -.
DR CTD; 5395; -.
DR eggNOG; KOG1978; Eukaryota.
DR GeneTree; ENSGT00940000155381; -.
DR OMA; RMRIIGQ; -.
DR OrthoDB; 4698638at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03484; MutL_Trans_hPMS_2_like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF52; MISMATCH REPAIR ENDONUCLEASE PMS2; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760}.
FT DOMAIN 225..362
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 642..786
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 421..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 548..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 826 AA; 92160 MW; A6F7C218B999D4BE CRC64;
MTDVCTSEPA GAIRAIDKHS VHRICSGQVV LSLATAVKEL VENSIDAGAT NVEVKLKECG
AEQIEVSDNG RGVEEANFEG LALKHHTSKL RDFSDLIHVE TFGFRGEALS SLCALSDLSV
ITCHESSQIG TKLLFDHKGH LVQQSPCPRQ QGTTVTLQQL FYTLPVRHKE FQRNIKKEFA
KMIHVLQAYC IVSTGVRITC SNQTGQGKRS AVLSTGGSQS MRDNIGAIFG PKQMQSLLPF
RQVSPSENIM EEYGLKDGDL PKQLFTLSGF VSTGDHGVGR SASDRQFFFI NSRPCDPVKV
SKLVNEVYHM YNRHQYPFVA LNIAVASDCV DVNVTPDKRQ IFLQEEKLLL AILKSSLINM
YEAGVNKMSL NYTPTVSSAS KEVHLPVEDK AEPAETNQPG TPSPKSTMNL AALKAAFSNQ
NSALSGSKSS TEKASKSGPS QKTLQCFFKG SVKSPVQPRR EAAKGSLGVW AELHRFRNER
ASVRENDSER GLAVESQDPQ HPVSFKPVVE NVTHDSSVSQ NLHEDPELQA EACSPVEDSV
IIPEAKRARR DDPRFTAERT PDTASSTTDV PVCLQRRTMP LHFCLQALAA GMKRLQQQQR
RRAADRLCYR RFRANISPGE NQRAEDELRR EISKDMFKEM EIIGQFNLGF IITKLNSDIF
MIDQHATDEK YNFEMLQQHT VLQGQRLIVP QKLHLTAVSE NVLLENVEIF QKNGFEFLID
EDAQVMERVK LVSLPTSRNW TFGPADIEEL IFMLSDSPGV MCRPSRVRQM FASRACRKSV
MIGTALSVSE MKKLVIHMGE IEHPWNCPHG RPTMRHLANL EIISQD
//
