ID A0A087Y6R6_POEFO Unreviewed; 1499 AA.
AC A0A087Y6R6;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Rho GTPase-activating protein 5-like {ECO:0000313|Ensembl:ENSPFOP00000013719.1};
GN Name=ARHGAP5 {ECO:0000313|Ensembl:ENSPFOP00000013719.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000013719.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000013719.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AYCK01021761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01021762; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01021763; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01021764; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01021765; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01021766; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01021767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPFOT00000013738.1; ENSPFOP00000013719.1; ENSPFOG00000013666.2.
DR GeneTree; ENSGT00940000154553; -.
DR OMA; MRNSFGG; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd22220; pseudoGTPaseD_p190RhoGAP-B; 1.
DR CDD; cd04373; RhoGAP_p190; 1.
DR Gene3D; 1.10.10.440; FF domain; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR002713; FF_domain.
DR InterPro; IPR036517; FF_domain_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039007; pG1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR032835; RhoGAP-FF1.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR045786; RhoGAP_pG1_pG2.
DR InterPro; IPR039006; RhoGAP_pG2.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR46005; RHO GTPASE-ACTIVATING PROTEIN 190; 1.
DR PANTHER; PTHR46005:SF2; RHO GTPASE-ACTIVATING PROTEIN 5; 1.
DR Pfam; PF01846; FF; 1.
DR Pfam; PF00071; Ras; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF16512; RhoGAP-FF1; 1.
DR Pfam; PF19518; RhoGAP_pG1_pG2; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00441; FF; 4.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF81698; FF domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51676; FF; 2.
DR PROSITE; PS51852; PG1; 1.
DR PROSITE; PS51853; PG2; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 427..481
FT /note="FF"
FT /evidence="ECO:0000259|PROSITE:PS51676"
FT DOMAIN 482..548
FT /note="FF"
FT /evidence="ECO:0000259|PROSITE:PS51676"
FT DOMAIN 590..763
FT /note="PG1 pseudoGTPase"
FT /evidence="ECO:0000259|PROSITE:PS51852"
FT DOMAIN 779..944
FT /note="PG2 pseudoGTPase"
FT /evidence="ECO:0000259|PROSITE:PS51853"
FT DOMAIN 1262..1449
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 975..1003
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1018..1054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1130..1152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1167..1225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1167..1197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1499 AA; 171794 MW; E5D7181AB3D81007 CRC64;
IMAKNKDARS LTFSISVVGL SGTEKEKGNC GVGKSCLCNR YVRPDADNYY SEHTSVLSTI
DFGGRVVNND HFLYWGEVNI RGEEGLDCKI QVIEQTEFID DQTFLPHRST NLQPYTKRAA
ATKLQSAEKL MYICTDQLGL EQDFDQRQMP DGKLNIDGFV LCVDVSKGCN RKFDDQMKFI
NSLYSQIVKS KKPIVVAASK CDEYMDQHLR DLQTFVASKK NLMLIETSAR FNVNVEHCFN
TLIQQIDKTR GKPKTIPYQD AYKVHRQLAA SVTERFEKLM VQTVRDYHIT WKTVINNLKG
QPDYDEFITL EGSRKARSMF TKYIAQLKQE HIKRRREEYL VTLPKTLNNI FCSLEEVEHL
SWPEAQTIIR NRQDFQCWFV VLDHTPWDES DHIDNSDRRI PFDLLNTPDG ERIYYSHVQH
LLSEKRRVEM KDRFKKTLER VHFISPGQPW EEVMCFVMED EAYKYITESD RKDVYCRHQQ
EIVEKAKEDF QEMLFEHAEL FYDLDLNATP SCDKMTEIHS VLNEEPRYRA LQKLAPDRES
LLLKHIGFVY HPTKETCLSG QNCVDLKVEQ VLANRLVQLD HGRSNLYYTS ANIDKINLCL
LGKDGLSQEL ANEIRAQSTD DEYTLDGKIY ELELLPVDVN STLLFSHTWV ATFKPHGCFC
VFNSIESLNC IGDCIGRIRA EIAQNRRDQF AQPLPFILIL SSQRDNVCKN IPILRHQGQQ
LANKLQCTFV DIPSGAFPRK FTEFQIKQGL RAVLEGLKHN LDVLAPLPCI KDMAETDLRI
VMCAMCWDPF SVDLILSPFL DSHCCSAGQQ GQSNTLILDK IIGDNRKRIQ VTILSYHSAI
GVRKDELVHG YILVYSAKRK ASMATLRAFL AEVQDVIPVQ MVAITDSQAD FFESDAIKEL
MTEGEHIATE IAAKFTALYS LSQYHRQTEV FTPFFNEVLE KKPNIEKAFL LDSSTRDCTT
SEDVFPTSPH SHLPAYTAYY PESDDDNEAP PPYSPIGDDV QLLPTPSERA KYRIDLEGNE
YPVHSTPAGD HDRNHKVPPP VRPKPVLPKP NVKKLDPNLL KTIEAGMRSN RRMPRGPVSH
TEDVEASDNY AEPVDTLVRS RGFHSDNIYV VPEDAHSRLV KITPPFLHSG GDEENGFDRK
SQAMRRPSKY KHRSKILFSK TKAYQRRFHS DSDGEEFCPA TQKKKKGRAH RGSEEDPLLS
PADPWKIGID NPAITSDPNV KKTKREKHRF NYTLAKQPKS TKPPKPLYPP TRRTWDSNYF
GVRLQNLVTS ERPIPLFIEK CVEYIERTGL TTEGVYRVSG NKTDQDNLQK QFDQDHSIDF
GEMDLAVNAV AGALKAFFAD LPDPLIPYSL HPELVEAANI MDYIERLEVL REIVKKFPPI
NYQIFKYIMT HLNRVSQHSK TTLMTADNLS ICFWPTLMRP DFENRDTLST TKLNQAVIET
FIVQSDYFFH GGDVAESSSN EGTPPPHCHN MVEALLPLQL PPPLQPQQIQ HTLPPDPLI
//
