ID A0A087YCJ9_POEFO Unreviewed; 284 AA.
AC A0A087YCJ9;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 24-JAN-2024, entry version 61.
DE RecName: Full=Homeobox protein engrailed-like {ECO:0000256|RuleBase:RU510713};
GN Name=EN1 {ECO:0000313|Ensembl:ENSPFOP00000015752.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000015752.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000015752.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the Engrailed homeobox family.
CC {ECO:0000256|RuleBase:RU510713}.
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DR EMBL; AYCK01006790; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007557131.1; XM_007557069.2.
DR AlphaFoldDB; A0A087YCJ9; -.
DR STRING; 48698.ENSPFOP00000015752; -.
DR Ensembl; ENSPFOT00000015774.1; ENSPFOP00000015752.2; ENSPFOG00000015708.1.
DR GeneID; 103141423; -.
DR KEGG; pfor:103141423; -.
DR CTD; 2019; -.
DR eggNOG; KOG0493; Eukaryota.
DR GeneTree; ENSGT00940000160811; -.
DR OMA; EHAPIME; -.
DR OrthoDB; 2897502at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR019549; Homeobox-engrailed_C-terminal.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR000747; Homeobox_engrailed.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR019737; Homoebox-engrailed_CS.
DR PANTHER; PTHR24341; HOMEOBOX PROTEIN ENGRAILED; 1.
DR PANTHER; PTHR24341:SF4; HOMEOBOX PROTEIN ENGRAILED-1; 1.
DR Pfam; PF10525; Engrail_1_C_sig; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00026; ENGRAILED.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00033; ENGRAILED; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 192..252
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 194..253
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 55..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 284 AA; 31301 MW; 7EC340A30E70026F CRC64;
MEEHKEPSSG RDSTEDESMS LSPNLPSPAM ILPHPAAQQA HRTTNFFIDN ILRPDFGCRK
EPSYRERSQT PGRENVNPLG ARPPHAGSLC LDSNCSSDSA SSSPSSSSST SSSPASKQSS
SKPGEAASNG AGRYADSPSS IMVMSGSNGG SPAGMKESQP LLWPAWVYCT RYSDRPSSGP
RTRKLKKKKN SKEDKRPRTA FTAEQLQRLK TEFQANRYIT EQRRQSLAQE LNLNESQIKI
WFQNKRAKIK KASGYKNGLA LQLMAQGLYN HSTTTVQEEK EESE
//
