ID A0A087YCL6_POEFO Unreviewed; 1182 AA.
AC A0A087YCL6;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=PH domain and leucine rich repeat protein phosphatase 1 {ECO:0000313|Ensembl:ENSPFOP00000015769.2};
GN Name=PHLPP1 {ECO:0000313|Ensembl:ENSPFOP00000015769.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000015769.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000015769.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AYCK01003164; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A087YCL6; -.
DR STRING; 48698.ENSPFOP00000015769; -.
DR Ensembl; ENSPFOT00000015791.2; ENSPFOP00000015769.2; ENSPFOG00000015697.2.
DR GeneTree; ENSGT00940000158137; -.
DR OMA; CHNQIRE; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR CDD; cd00143; PP2Cc; 1.
DR Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR036457; PPM-type-like_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF37; PH DOMAIN AND LEUCINE-RICH REPEAT PROTEIN PHOSPHATASE 2; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF00481; PP2C; 1.
DR SMART; SM00364; LRR_BAC; 9.
DR SMART; SM00369; LRR_TYP; 9.
DR SMART; SM00332; PP2Cc; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF81606; PP2C-like; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS51746; PPM_2; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 590..837
FT /note="PPM-type phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51746"
FT REGION 857..917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1046..1065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1078..1182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 880..917
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1048..1062
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1148..1162
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1182 AA; 130429 MW; 0BD2B4185B9A9148 CRC64;
MHILPLIGGK VEEVKKHNHC LAFSSAGPQS QTYYVSFDSF TEHLRWHRHA AKMVSQRINS
VDLSCCSLEL LPPNLFYSHD LTHLNLKHNF LPADHHLQQL QRFSRLRSLN LSNNHLGQFP
LAICDIPTLT EVNLSCNYMD SVPSSVGAMS NLQTFLLDGN SLSELPCELG SLQRLSYLGL
SFNQFSHVPQ VLERLASMEK LCMAGNNQEM LTLQNFRLLH VKHIDLRLNK ISVMVPDEPD
LLRHVTQLDL RDNRLTELDA SIFPRLEVLH CERNHITCLK VKGSLLKGIY ASNNELRQLD
VSPVPSNLTY MDISKNHMES LPDWLCEAKK LEVLDVSHNL ITELPARLFC SNSLRKLSAG
HNQLQKLPER VERPLLEVLD VQHNQLVELP CNLFLKSNSL RCVNASANKL EHLPPSSLSE
ESHSILQELY LTNNWLTDKC VPMLTGHTHL RVLHMAYNHL QTFPASKMAK LEELEEVDLS
GNMLKTVPTT IMNCRRMHTL IAHSNSIEVF PEVMQLMEMK CVDLSCNELS EITLPENLPP
KLQELDLTGN PRLNLDHKTL EQLNNIRCFH IDPPPTFSSN EASGGPAVWS HGYTEASGVK
NKLCVAALSV NSFCGSREAL YGVFDGDRNV EVPYLLQCTM NDVLAEEIHK TKSEEDYMTN
TFLVMQRKLG TAGQKLGGSA ALCHIRHDPT DPSGCFVLTA ANVGKCQAIL CRDGKPMSLS
LLHNVGLEEE YRRIRQHRAI VTEDNKVNGV TDSTRIMGYS FLYPSVIPCP YVQTVTLTPQ
DEFFILGSRG LWDAVSPTEA VEAVRNVPDG LAAAKKLCTL AQGYGCTDSL SAVVVQLSVS
EDCCSCCCSD PPQPPPSPGL GAYPSSSSAI KDRPSDGSLP VPPSSCSEIS SEISTSEMSS
EVGSTASSDE PPQSSFVLLQ DQPHHPQLHL HHQAQLLSLQ QQQSHTTSQS CQYLLPGSEL
ASARNCCALH PACLAGSFQR QLSSATFSSA LSDNGLDSED EEPIAGVFSN GSRVEVEADV
HCLKAELSQL SSSQSLVPAS SIQERTLLNL PPPPPPPCTP EPLEDGVDLN LAEAENGLER
DESWQGVGAG AGDGGKFPGK RRVNGSVARQ EKSHNLIEVA ADAPSKKSGG YFTAPAQPDP
DDQFIIPPEL EEEVKEIMKQ HQQKQQKPAG TDQPTDYYDT PL
//
